on December 31, 2001
Published online before print December 31, 2001, doi: 10.1161/hc0602.103583
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Submitted on October 19, 2001
From the Cardiovascular Health Research
Unit, Departments of Medicine (R.N.L., D.S.S., R.M.P., S.W., R.H.K.,
M.K.C., L.A.C.) and Epidemiology (D.S.S.),
University of Washington, Seattle; Public Health Sciences Division
(I.B.K.), Fred Hutchinson Cancer Research Center, Seattle, Wash; and
the Institute for Social Research (T.E.R.), University of Michigan, Ann
Arbor. * To whom correspondence should be addressed. E-mail: rozenl{at}u.washington.edu.
Background—The
relation of trans-fatty acid
intake to life-threatening arrhythmias and primary cardiac
arrest is unknown. Methods and Results—We
investigated the association of
trans-fatty acid intake,
assessed through a biomarker, with the risk of primary cardiac arrest
in a population-based case-control study. Cases, aged 25 to 74 years,
were out-of-hospital cardiac arrest patients attended by paramedics in
Seattle, Washington from 1988 to 1999 (n=179). Controls, matched to
cases by age and sex, were randomly identified from the
community (n=285). Participants were free of previous clinically
diagnosed heart disease. Blood was obtained at the time of cardiac
arrest (cases) or at the time of an interview (controls) to assess
trans-fatty acid intake. Higher
total trans-fatty acids in red
blood cell membranes was associated with a modest increase in the risk
of primary cardiac arrest after adjustment for medical and lifestyle
risk factors (odds ratio for interquintile range, 1.5; 95% CI, 1.0 to
2.1). However, trans isomers of
oleic acid were not associated with risk (odds ratio for interquintile
range, 0.8; 95% CI, 0.5 to 1.2), whereas higher levels of
trans isomers of linoleic acid
were associated with 3-fold increase in risk (odds ratio for
interquintile range, 3.1; 95% CI, 1.7 to
5.4). Conclusions—These
findings suggest that dietary intake of total
trans-fatty acids is associated
with modest increase and trans
isomers of linoleic acid with a larger increase in the risk of primary
cardiac arrest. These associations need to be confirmed in future
studies that distinguish between
trans isomers of linoleic acid
and trans isomers of oleic
acid.
Revised on December 3, 2001
Accepted on December 14, 2001
Cell Membrane
Trans-Fatty Acids and the Risk
of Primary Cardiac Arrest
Key words: heart arrest • fatty acids • epidemiology
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