Published Online
on October 29, 2007

A more recent version of this article appeared on November 13, 2007

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Submitted on May 27, 2007
Accepted on September 7, 2007

Obesity, Adipokines, and Abdominal Aortic Aneurysm. Health in Men Study

Jonathan Golledge MChir, FRACS, FRCS^*, Paula Clancy PhD, Konrad Jamrozik DPhil, FAFPHM, and Paul E. Norman DS, FRACS, FRCS

From the Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Australia (J.G., P.C.); School of Population Health, University of Queensland, Herston, Queensland, Australia (K.J.); and School of Surgery and Pathology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia (P.E.N.).

^* To whom correspondence should be addressed. E-mail: jonathan.golledge{at}jcu.edu.au.

Background—Obesity is associated with occlusive artery disease but is not considered a risk factor for abdominal aortic aneurysm (AAA). We investigated the association between anthropometric measures of obesity, serum adipokines, and AAA.

Methods and Results—As part of a population study, we screened 12 203 men 65 to 83 years of age for AAA using ultrasound; 875 had an AAA (30 mm). Cardiovascular risk factors and waist and hip circumference were recorded. Serum adipokines were measured in 952 men, 318 of whom had an AAA. Waist circumference (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.06 to 1.22) and waist-to-hip ratio (OR, 1.22; 95% CI, 1.09 to 1.37) were independently associated with AAA after adjustment for other known risk factors. The association was stronger for AAA 40 mm (waist-to-hip ratio: OR, 1.53; 95% CI, 1.26 to 1.85). Serum resistin concentration was strongly independently associated with AAA (OR, 1.53; 95% CI, 1.32 to 1.76) and aortic diameter (=0.19, P<0.0001). Serum adiponectin was associated with AAA 30 mm (OR, 1.26; 95% CI, 1.07 to 1.50) but not AAA 40 mm (OR, 1.03; 95% CI, 0.77 to 1.39). Serum leptin was not associated with AAA.

Conclusions—Measures of obesity are independently associated with AAA. Serum resistin concentrations were more strongly associated with aortic diameter than adipokines that are more intimately associated with adiposity. Further studies are required to investigate the mechanisms linking resistin and AAA.

Key words: aortic aneurysm, abdominal • obesity • resistin

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