Published Online
on March 21, 2007

A more recent version of this article appeared on April 10, 2007

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Drug Therapy of High-Risk Lipid Abnormalities in Children and Adolescents. A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee, Council of Cardiovascular Disease in the Young, With the Council on Cardiovascular Nursing

Brian W. McCrindle MD, MPH, Chair, Elaine M. Urbina MD, Barbara A. Dennison MD, FAHA, Marc S. Jacobson MD, FAHA, Julia Steinberger MD, MS, Albert P. Rocchini MD, FAHA, Laura L. Hayman PhD, RN, FAHA, and Stephen R. Daniels MD, PhD, FAHA

Abstract--Despite compliance with lifestyle recommendations, some children and adolescents with high-risk hyperlipidemia will require lipid-lowering drug therapy, particularly those with familial hypercholesterolemia. The purpose of this statement is to examine new evidence on the association of lipid abnormalities with early atherosclerosis, discuss challenges with previous guidelines, and highlight results of clinical trials with statin therapy in children and adolescents with familial hypercholesterolemia or severe hypercholesterolemia. Recommendations are provided to guide decision-making with regard to patient selection, initiation, monitoring, and maintenance of drug therapy.

Key words: AHA Scientific Statements • lipids • pediatrics • drugs • hypercholesterolemia

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