Published Online
on August 28, 2006

A more recent version of this article appeared on September 19, 2006

This Article Free upon publication Full Text (PDF) All Versions of this Article: 114/12/1321    most recent CIRCULATIONAHA.106.177276v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kern, M. J. Articles by Spaan, J. A.E. Search for Related Content PubMed PubMed Citation Articles by Kern, M. J. Articles by Spaan, J. A.E. Related Collections Catheter-based coronary and valvular interventions: other Catheter-based coronary interventions: stents Coronary imaging: angiography/ultrasound/Doppler/CC

Submitted on ,
Accepted on ,

Physiological Assessment of Coronary Artery Disease in the Cardiac Catheterization Laboratory. A Scientific Statement From the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology

Morton J. Kern MD, FAHA, Chair, Amir Lerman MD, Co-Chair, Jan-Willen Bech MD, Bernard De Bruyne MD, PhD, Eric Eeckhout MD, PhD, William F. Fearon MD, Stuart T. Higano MD, FAHA, Michael J. Lim MD, Martijn Meuwissen MD, Jan J. Piek MD, Nico H.J. Pijls MD, PhD, FAHA, Maria Siebes PhD, and Jos A.E. Spaan PhD, FAHA

Abstract--With advances in technology, the physiological assessment of coronary artery disease in patients in the catheterization laboratory has become increasingly important in both clinical and research applications, but this assessment has evolved without standard nomenclature or techniques of data acquisition and measurement. Some questions regarding the interpretation, application, and outcome related to the results also remain unanswered. Accordingly, this consensus statement was designed to provide the background and evidence about physiological measurements and to describe standard methods for data acquisition and interpretation. The most common uses and support data from numerous clinical studies for the physiological assessment of coronary artery disease in the cardiac catheterization laboratory are reviewed. The goal of this statement is to provide a logical approach to the use of coronary physiological measurements in the catheterization lab to assist both clinicians and investigators in improving patient care.

Key words: AHA Scientific Statements • angiography • catheterization

This article has been cited by other articles:

				J. Escaned, A. Flores, P. Garcia-Pavia, J. Segovia, J. Jimenez, P. Aragoncillo, C. Salas, F. Alfonso, R. Hernandez, D. J. Angiolillo, et al. Assessment of Microcirculatory Remodeling With Intracoronary Flow Velocity and Pressure Measurements: Validation With Endomyocardial Sampling in Cardiac Allografts Circulation, October 20, 2009; 120(16): 1561 - 1568. [Abstract] [Full Text] [PDF]

				P. Ganz and P. Y. Hsue Assessment of Structural Disease in the Coronary Microvasculature Circulation, October 20, 2009; 120(16): 1555 - 1557. [Full Text] [PDF]

				K. L. Gould Does Coronary Flow Trump Coronary Anatomy? J. Am. Coll. Cardiol. Img., August 1, 2009; 2(8): 1009 - 1023. [Abstract] [Full Text] [PDF]

				A. Goette, A. Bukowska, D. Dobrev, J. Pfeiffenberger, H. Morawietz, D. Strugala, I. Wiswedel, F.-W. Rohl, C. Wolke, S. Bergmann, et al. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles Eur. Heart J., June 1, 2009; 30(11): 1411 - 1420. [Abstract] [Full Text] [PDF]

				G. Sarno, I. Decraemer, P. K. Vanhoenacker, B. De Bruyne, M. Hamilos, T. Cuisset, E. Wyffels, J. Bartunek, G. R. Heyndrickx, and W. Wijns On the Inappropriateness of Noninvasive Multidetector Computed Tomography Coronary Angiography to Trigger Coronary Revascularization: A Comparison With Invasive Angiography J. Am. Coll. Cardiol. Intv., June 1, 2009; 2(6): 550 - 557. [Abstract] [Full Text] [PDF]

				A. Cassar, P. Chareonthaitawee, C. S. Rihal, A. Prasad, R. J. Lennon, L. O. Lerman, and A. Lerman Lack of Correlation Between Noninvasive Stress Tests and Invasive Coronary Vasomotor Dysfunction in Patients With Nonobstructive Coronary Artery Disease Circ Cardiovasc Interv, June 1, 2009; 2(3): 237 - 244. [Abstract] [Full Text] [PDF]

				B. Beleslin, M. Ostojic, A. Djordjevic-Dikic, V. Vukcevic, S. Stojkovic, M. Nedeljkovic, G. Stankovic, D. Orlic, N. Milic, J. Stepanovic, et al. The value of fractional and coronary flow reserve in predicting myocardial recovery in patients with previous myocardial infarction Eur. Heart J., November 1, 2008; 29(21): 2617 - 2624. [Abstract] [Full Text] [PDF]

				A. R. Pries, H. Habazettl, G. Ambrosio, P. R. Hansen, J. C. Kaski, V. Schachinger, H. Tillmanns, G. Vassalli, I. Tritto, M. Weis, et al. A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings Cardiovasc Res, November 1, 2008; 80(2): 165 - 174. [Abstract] [Full Text] [PDF]

				M. J. Kern Limitations of Angiographic Predictors of Bypass Graft Patency J. Am. Coll. Cardiol., September 2, 2008; 52(10): 886 - 887. [Full Text] [PDF]

				W. B. Meijboom, C. A.G. Van Mieghem, N. van Pelt, A. Weustink, F. Pugliese, N. R. Mollet, E. Boersma, E. Regar, R. J. van Geuns, P. J. de Jaegere, et al. Comprehensive Assessment of Coronary Artery Stenoses: Computed Tomography Coronary Angiography Versus Conventional Coronary Angiography and Correlation With Fractional Flow Reserve in Patients With Stable Angina J. Am. Coll. Cardiol., August 19, 2008; 52(8): 636 - 643. [Abstract] [Full Text] [PDF]

				C. Kolyva, J. A. E. Spaan, J. J. Piek, and M. Siebes Windkesselness of coronary arteries hampers assessment of human coronary wave speed by single-point technique Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H482 - H490. [Abstract] [Full Text] [PDF]

				G. T. Gyenes and W. A. Ghali Should All Patients With Asymptomatic but Significant (>50%) Left Main Coronary Artery Stenosis Undergo Surgical Revascularization? Circulation, July 22, 2008; 118(4): 422 - 425. [Full Text] [PDF]

				N. Beohar, A. K. Erdogan, D. C. Lee, H. N. Sabbah, M. J. Kern, J. Teerlink, R. O. Bonow, and M. Gheorghiade Acute heart failure syndromes and coronary perfusion. J. Am. Coll. Cardiol., July 1, 2008; 52(1): 13 - 16. [Abstract] [Full Text] [PDF]

				N. Reichek and D. Alexander Coronary artery function: out of the cath lab and into the magnet. J. Am. Coll. Cardiol. Img., March 1, 2008; 1(2): 174 - 176. [Full Text] [PDF]

				S. Erbs, A. Linke, V. Schachinger, B. Assmus, H. Thiele, K.-W. Diederich, C. Hoffmann, S. Dimmeler, T. Tonn, R. Hambrecht, et al. Restoration of Microvascular Function in the Infarct-Related Artery by Intracoronary Transplantation of Bone Marrow Progenitor Cells in Patients With Acute Myocardial Infarction: The Doppler Substudy of the Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction (REPAIR-AMI) Trial Circulation, July 24, 2007; 116(4): 366 - 374. [Abstract] [Full Text] [PDF]

				A. Abbate, G. G.L. Biondi-Zoccai, P. Agostoni, M. J. Lipinski, and G. W. Vetrovec Recurrent angina after coronary revascularization: a clinical challenge Eur. Heart J., May 1, 2007; 28(9): 1057 - 1065. [Abstract] [Full Text] [PDF]