on February 14, 2006
Circulation. 2006
Published online before print February 13, 2006, doi: 10.1161/CIRCULATIONAHA.105.595496
Published online before print February 13, 2006, doi: 10.1161/CIRCULATIONAHA.105.595496
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Submitted on October 14, 2005
From the University Department of Cardiovascular Sciences, University of Leicester, Leicester, UK (B.W., P.S.L., H.T.); National Heart & Lung Institute, International Center for Circulatory Health at St Mary’s Hospital, Imperial College London W2 ILA, London, UK (S.M.T., A.D.H.); Clinical Epidemiology Group, University Department of Medicine, Manchester Royal Infirmary, Manchester, UK (K.C.); Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen’s Green, Dublin, Ireland (A.S.); Department of Clinical Pharmacology, William Harvey Research Institute, Bart’s & The London, Queen Mary’s School of Medicine & Dentistry, London, UK (D.C.); and University of New South Wales, Sydney, Australia (M.O.). * To whom correspondence should be addressed. E-mail: bw17{at}le.ac.uk.
Background--Different blood pressure (BP)-lowering drugs could have different effects on central aortic pressures and thus cardiovascular outcome despite similar effects on brachial BP. The Conduit Artery Function Evaluation (CAFE) study, a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), examined the impact of 2 different BP lowering-regimens (atenolol±thiazide-based versus amlodipine±perindopril-based therapy) on derived central aortic pressures and hemodynamics. Methods and Results--The CAFE study recruited 2199 patients in 5 ASCOT centers. Radial artery applanation tonometry and pulse wave analysis were used to derive central aortic pressures and hemodynamic indexes on repeated visits for up to 4 years. Most patients received combination therapy throughout the study. Despite similar brachial systolic BPs between treatment groups ( Conclusions--BP-lowering drugs can have substantially different effects on central aortic pressures and hemodynamics despite a similar impact on brachial BP. Moreover, central aortic pulse pressure may be a determinant of clinical outcomes, and differences in central aortic pressures may be a potential mechanism to explain the different clinical outcomes between the 2 BP treatment arms in ASCOT.
Revised on December 14, 2005
Accepted on December 16, 2005
Differential Impact of Blood Pressure-Lowering Drugs on Central Aortic Pressure and Clinical Outcomes. Principal Results of the Conduit Artery Function Evaluation (CAFE) Study
The CAFE Investigators, for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Investigators ,
0.7 mm Hg; 95% CI, -0.4 to 1.7; P=0.2), there were substantial reductions in central aortic pressures with the amlodipine regimen (central aortic systolic BP, 4.3 mm Hg; 95% CI, 3.3 to 5.4; P<0.0001; central aortic pulse pressure, 3.0 mm Hg; 95% CI, 2.1 to 3.9; P<0.0001). Cox proportional-hazards modeling showed that central pulse pressure was significantly associated with a post hoc-defined composite outcome of total cardiovascular events/procedures and development of renal impairment in the CAFE cohort (unadjusted, P<0.0001; adjusted for baseline variables, P<0.05).
Key words: aorta • arteries • blood pressure • hemodynamics • hypertension
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|
|
|
|
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|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 M. E. Safar, A. D. Protogerou, and J. Blacher Statins, Central Blood Pressure, and Blood Pressure Amplification Circulation, January 6, 2009; 119(1): 9 - 12. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
B. E. Westerhof, I. Guelen, W. J. Stok, H. A. J. Lasance, C. A. P. L. Ascoop, K. H. Wesseling, N. Westerhof, W. J. W. Bos, N. Stergiopulos, and J. A. E. Spaan Individualization of transfer function in estimation of central aortic pressure from the peripheral pulse is not required in patients at rest J Appl Physiol, December 1, 2008; 105(6): 1858 - 1863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Santhanam, D. W. Christianson, D. Nyhan, and D. E. Berkowitz Arginase and vascular aging J Appl Physiol, November 1, 2008; 105(5): 1632 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Andrade, L. Er, A. Ignaszewski, and A. Levin Exploration of Association of 1,25-OH2D3 with Augmentation Index, a Composite Measure of Arterial Stiffness Clin. J. Am. Soc. Nephrol., November 1, 2008; 3(6): 1800 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 D. Nyhan and D. E. Berkowitz Perioperative Blood Pressure Management: Does Central Vascular Stiffness Matter? Anesth. Analg., October 1, 2008; 107(4): 1103 - 1106. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 R. Dietz, R. Dechend, C.-M. Yu, M. Bheda, J. Ford, M. F. Prescott, and D. L. Keefe Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension1 Journal of Renin-Angiotensin-Aldosterone System, September 1, 2008; 9(3): 163 - 175. [Abstract] [PDF]
|
|
|
|
|
|
C.-J. Thore, J. Stalhand, and M. Karlsson Toward a noninvasive subject-specific estimation of abdominal aortic pressure Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1156 - H1164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fox Benefits of perindopril all along the cardiovascular continuum: the level of evidence Eur. Heart J. Suppl., September 1, 2008; 10(suppl_G): G4 - G12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Poulter Selecting a fixed combination to improve morbidity/mortality: the weight of evidence with ASCOT Eur. Heart J. Suppl., September 1, 2008; 10(suppl_G): G21 - G28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Brown Aliskiren Circulation, August 12, 2008; 118(7): 773 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Desjardins, I. Lobysheva, M. Pelat, B. Gallez, O. Feron, C. Dessy, and J.-L. Balligand Control of blood pressure variability in caveolin-1-deficient mice: role of nitric oxide identified in vivo through spectral analysis Cardiovasc Res, August 1, 2008; 79(3): 527 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Pini, M. C. Cavallini, V. Palmieri, N. Marchionni, M. Di Bari, R. B. Devereux, G. Masotti, and M. J. Roman Central but not brachial blood pressure predicts cardiovascular events in an unselected geriatric population: the ICARe Dicomano Study. J. Am. Coll. Cardiol., June 24, 2008; 51(25): 2432 - 2439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Olufadi and C D Byrne Clinical and laboratory diagnosis of the metabolic syndrome J. Clin. Pathol., June 1, 2008; 61(6): 697 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Saito, H Okayama, K Nishimura, A Ogimoto, T Ohtsuka, K Inoue, G Hiasa, T Sumimoto, and J Higaki Possible link between large artery stiffness and coronary flow velocity reserve Heart, June 1, 2008; 94(6): e20 - e20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Edwards, M. S. Roy, and R. Y. Prasad Wave reflection augments central systolic and pulse pressures during facial cooling Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2535 - H2539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. McEniery, Yasmin, B. McDonnell, M. Munnery, S. M. Wallace, C. V. Rowe, J. R. Cockcroft, I. B. Wilkinson, and on Behalf of the Anglo-Cardiff Collaborative Trial Central Pressure: Variability and Impact of Cardiovascular Risk Factors: The Anglo-Cardiff Collaborative Trial II Hypertension, June 1, 2008; 51(6): 1476 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Avolio Central Aortic Blood Pressure and Cardiovascular Risk: A Paradigm Shift? Hypertension, June 1, 2008; 51(6): 1470 - 1471. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
F. H. Messerli, S. Bangalore, and S. Julius Risk/Benefit Assessment of {beta}-Blockers and Diuretics Precludes Their Use for First-Line Therapy in Hypertension Circulation, May 20, 2008; 117(20): 2706 - 2715. [Full Text] [PDF]
|
|
|
|
|
|
B. Williams The Year in Hypertension J. Am. Coll. Cardiol., May 6, 2008; 51(18): 1803 - 1817. [Full Text] [PDF]
|
|
|
|
 |
|
 N L Mills, J J Miller, A Anand, S D Robinson, G A Frazer, D Anderson, L Breen, I B Wilkinson, C M McEniery, K Donaldson, et al. Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk Thorax, April 1, 2008; 63(4): 306 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Nier, L. S. Harrington, M. J. Carrier, and P. D. Weinberg Evidence for a specific influence of the nitrergic pathway on the peripheral pulse waveform in rabbits Exp Physiol, April 1, 2008; 93(4): 503 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jankowski, K. Kawecka-Jaszcz, D. Czarnecka, M. Brzozowska-Kiszka, K. Styczkiewicz, M. Loster, M. Kloch-Badelek, J. Wilinski, A. M. Curylo, D. Dudek, et al. Pulsatile but Not Steady Component of Blood Pressure Predicts Cardiovascular Events in Coronary Patients Hypertension, April 1, 2008; 51(4): 848 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Safar and H. Smulyan Central Blood Pressure and Hypertension Hypertension, April 1, 2008; 51(4): 819 - 820. [Full Text] [PDF]
|
|
|
|
|
|
M. L. Macedo, D. Luminoso, M. D. Savvidou, C. M. McEniery, and K. H. Nicolaides Maternal Wave Reflections and Arterial Stiffness in Normal Pregnancy as Assessed by Applanation Tonometry Hypertension, April 1, 2008; 51(4): 1047 - 1051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gojanovic, F. Feihl, L. Liaudet, and B. Waeber Review: Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension Journal of Renin-Angiotensin-Aldosterone System, March 1, 2008; 9(1): 1 - 9. [Abstract] [PDF]
|
|
|
|
|
|
M. P Schneider, C. Delles, A. U Klingbeil, M. Ludwig, R. E Kolloch, M. Krekler, K. O Stumpe, and R. E Schmieder Effect of angiotensin receptor blockade on central haemodynamics in essential hypertension: results of a randomised trial Journal of Renin-Angiotensin-Aldosterone System, March 1, 2008; 9(1): 49 - 56. [Abstract] [PDF]
|
|
|
|
|
|
M. Shimizu and K. Kario Review: Role of the augmentation index in hypertension Therapeutic Advances in Cardiovascular Disease, February 1, 2008; 2(1): 25 - 35. [Abstract] [PDF]
|
|
|
|
|
|
M. Frimodt-Moller, A. H. Nielsen, A.-L. Kamper, and S. Strandgaard Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease Nephrol. Dial. Transplant., February 1, 2008; 23(2): 594 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Edwards, C. R. Mastin, and R. W. Kenefick Wave reflection and central aortic pressure are increased in response to static and dynamic muscle contraction at comparable workloads J Appl Physiol, February 1, 2008; 104(2): 439 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
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 L. M. Prisant Nebivolol: Pharmacologic Profile of an Ultraselective, Vasodilatory {beta}1-Blocker J. Clin. Pharmacol., February 1, 2008; 48(2): 225 - 239. [Abstract] [Full Text] [PDF]
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M. Osranek, J. H. Eisenach, B. K. Khandheria, K. Chandrasekaran, J. B. Seward, and M. Belohlavek Arterioventricular Coupling and Ventricular Efficiency After Antihypertensive Therapy: A Noninvasive Prospective Study Hypertension, February 1, 2008; 51(2): 275 - 281. [Abstract] [Full Text] [PDF]
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F. H. Messerli and S. Bangalore Reply. J. Am. Coll. Cardiol., January 29, 2008; 51(4): 517 - 518. [Full Text] [PDF]
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K. Fox, J. S. Borer, A. J. Camm, N. Danchin, R. Ferrari, J. L. Lopez Sendon, P. G. Steg, J.-C. Tardif, L. Tavazzi, M. Tendera, et al. Reply J. Am. Coll. Cardiol., January 22, 2008; 51(3): 331 - 332. [Full Text] [PDF]
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F. H. Messerli and S. Bangalore Resting Heart Rate and Cardiovascular Disease: The Beta-Blocker Hypertension Paradox J. Am. Coll. Cardiol., January 22, 2008; 51(3): 330 - 331. [Full Text] [PDF]
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 P. Ou, D. S. Celermajer, O. Raisky, O. Jolivet, F. Buyens, A. Herment, D. Sidi, D. Bonnet, and E. Mousseaux Angular (Gothic) aortic arch leads to enhanced systolic wave reflection, central aortic stiffness, and increased left ventricular mass late after aortic coarctation repair: Evaluation with magnetic resonance flow mapping J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 62 - 68. [Abstract] [Full Text] [PDF]
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R. A. Payne and D. J. Webb Peripheral Augmentation Index: Shouldering the Central Pressure Load Hypertension, January 1, 2008; 51(1): 37 - 38. [Full Text] [PDF]
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R. S. Vasan Pathogenesis of Elevated Peripheral Pulse Pressure: Some Reflections and Thinking Forward Hypertension, January 1, 2008; 51(1): 33 - 36. [Full Text] [PDF]
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S. Munir, A. Guilcher, T. Kamalesh, B. Clapp, S. Redwood, M. Marber, and P. Chowienczyk Peripheral Augmentation Index Defines the Relationship Between Central and Peripheral Pulse Pressure Hypertension, January 1, 2008; 51(1): 112 - 118. [Abstract] [Full Text] [PDF]
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K. O. Stumpe, E. Agabiti-Rosei, T. Zielinski, D. Schremmer, J. Scholze, P. Laeis, P. Schwandt, and M. Ludwig Original Research: Carotid intima-media thickness and plaque volume changes following 2-year angiotensin II-receptor blockade. The Multicentre Olmesartan atherosclerosis Regression Evaluation (MORE) study Therapeutic Advances in Cardiovascular Disease, December 1, 2007; 1(2): 97 - 106. [Abstract] [PDF]
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C. M. Ferrario, J. Basile, W. Bestermann, E. Frohlich, M. Houston, D. T. Lackland, R. D. Smith, and D. L. Wise Review: The role of noninvasive hemodynamic monitoring in the evaluation and treatment of hypertension Therapeutic Advances in Cardiovascular Disease, December 1, 2007; 1(2): 113 - 118. [Abstract] [PDF]
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 M. F. O'Rourke Arterial aging: pathophysiological principles Vascular Medicine, November 1, 2007; 12(4): 329 - 341. [Abstract] [PDF]
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J.-G. Wang and Y. Li Response to Amlodipine and Stroke Prevention Hypertension, October 1, 2007; 50(4): e72 - e72. [Full Text] [PDF]
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A. Benjo, R. E. Thompson, D. Fine, C. W. Hogue, D. Alejo, A. Kaw, G. Gerstenblith, A. Shah, D. E. Berkowitz, and D. Nyhan Pulse Pressure Is an Age-Independent Predictor of Stroke Development After Cardiac Surgery Hypertension, October 1, 2007; 50(4): 630 - 635. [Abstract] [Full Text] [PDF]
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M. Naya, T. Tsukamoto, K. Morita, C. Katoh, T. Furumoto, S. Fujii, N. Tamaki, and H. Tsutsui Olmesartan, But Not Amlodipine, Improves Endothelium-Dependent Coronary Dilation in Hypertensive Patients J. Am. Coll. Cardiol., September 18, 2007; 50(12): 1144 - 1149. [Abstract] [Full Text] [PDF]
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K. Fox Contribution of perindopril to cardiology: 20 years of success Eur. Heart J. Suppl., September 1, 2007; 9(suppl_E): E10 - E19. [Abstract] [Full Text] [PDF]
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M. J Brown Renin: friend or foe? Heart, September 1, 2007; 93(9): 1026 - 1033. [Abstract] [Full Text] [PDF]
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 A. V. Chobanian Isolated Systolic Hypertension in the Elderly N. Engl. J. Med., August 23, 2007; 357(8): 789 - 796. [Full Text] [PDF]
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S. Bangalore, F. H. Messerli, J. B. Kostis, and C. J. Pepine Cardiovascular Protection Using Beta-Blockers: A Critical Review of the Evidence J. Am. Coll. Cardiol., August 14, 2007; 50(7): 563 - 572. [Abstract] [Full Text] [PDF]
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