on February 6, 2006
Published online before print February 6, 2006, doi: 10.1161/CIRCULATIONAHA.105.591602
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Submitted on September 26, 2005
From St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., B.I.M., M.C., C.R.T., J.M.), and University Hospital of Lund, Lund, Sweden (J.H., P.O.K., J.O.S.). * To whom correspondence should be addressed. E-mail: webb{at}providencehealth.bc.ca.
Background--Mitral annuloplasty is the most common surgical procedure performed for ischemic mitral regurgitation (MR). Surgical mitral annuloplasty is limited by morbidity, mortality, and MR recurrence. We evaluated the safety and feasibility of a transvenous catheter-delivered implantable device to provide a percutaneous alternative to surgical mitral annuloplasty. Methods and Results--Five patients with chronic ischemic MR underwent percutaneous transvenous implantation of an annuloplasty device in the coronary sinus. Implantation was successful in 4 patients. Baseline MR in the entire group was grade 3.0±0.7 and was reduced to grade 1.6±1.1 at the last postimplantation visit when the device was intact or the last postprocedural visit in the patient in whom the device was not successfully implanted. Separation of the bridge section of the device occurred in 3 of 4 implanted devices and was detected at 28 to 81 days after implantation. There were no postprocedural device-related complications. Conclusions--Percutaneous implantation of a device intended to remodel the mitral annulus is feasible. Initial experience suggests a possible favorable effect on MR. Percutaneous transvenous mitral annuloplasty warrants further evaluation as a less invasive alternative to surgical annuloplasty.
Revised on November 9, 2005
Accepted on December 2, 2005
Percutaneous Transvenous Mitral Annuloplasty. Initial Human Experience With Device Implantation in the Coronary Sinus
John G. Webb MD*,
Key words: annuloplasty • coronary sinus • heart failure • mitral valve • regurgitation
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