Published Online
on July 5, 2005

A more recent version of this article appeared on July 19, 2005

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Submitted on July 20, 2004
Revised on December 1, 2004
Accepted on December 27, 2004

Muscle Sympathetic Nerve Activity Averaged Over 1 Minute Parallels Renal and Cardiac Sympathetic Nerve Activity in Response to a Forced Baroreceptor Pressure Change

Atsunori Kamiya MD, PhD^*, Toru Kawada MD, PhD, Kenta Yamamoto PhD, Daisaku Michikami PhD, Hideto Ariumi PhD, Tadayoshi Miyamoto PhD, Kazunori Uemura MD, Masaru Sugimachi MD, PhD, and Kenji Sunagawa MD, PhD

From the Department of Cardiovascular Dynamics (A.K., T.K., K.Y., D.M., H.A., T.M., K.U., M.S.), National Cardiovascular Center Research Institute, Osaka, and the Department of Cardiovascular Medicine (K.S.), Kyusyu University Graduate School of Medical Sciences, Fukuoka, Japan.

^* To whom correspondence should be addressed. E-mail: kamiya{at}ri.ncvc.go.jp.

Background--Despite the accumulated knowledge of human muscle sympathetic nerve activity (SNA) as measured by microneurography, whether muscle SNA parallels renal and cardiac SNAs remains unknown.

Method and Results--In experiment 1, muscle (microneurography, tibial nerve), renal, and cardiac SNAs were recorded in anesthetized rabbits (n=6) while arterial pressure was changed by intravenous bolus injections of nitroprusside (3 µg/kg) followed by phenylephrine (3 µg/kg). In experiment 2, the carotid sinus region was vascularly isolated in anesthetized, vagotomized, and aorta-denervated rabbits (n=10). The 3 SNAs were recorded while intracarotid sinus pressure was increased stepwise from 40 to 160 mm Hg in 20-mm Hg increments maintained for 60 seconds each. Muscle SNA averaged over 1 minute was well correlated with renal (r=0.96±0.01, mean±SE) and cardiac (r=0.96±0.01) SNAs in experiment 1 (baroreflex closed-loop condition) and also with renal (r=0.97±0.01) and cardiac (r=0.97±0.01) SNAs in experiment 2 (baroreflex open-loop condition).

Conclusions--Muscle SNA averaged over 1 minute parallels renal and cardiac SNAs in response to a forced baroreceptor pressure change.

Key words: catecholamines • muscles • nervous system, autonomic • nervous system, sympathetic

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