on May 31, 2005
Published online before print May 31, 2005, doi: 10.1161/CIRCULATIONAHA.104.489534
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Submitted on July 8, 2004
From Evans Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Mass (L.D., R.C.E.); Department of Epidemiology, University of Alabama, Birmingham (D.K.A.); Division of Radiologic Sciences, Wake Forest University School of Medicine, Winston-Salem, NC (J.J.C.); Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (J.H.E.); Department of Cardiovascular Genetics, University of Utah, Salt Lake City (P.N.H.); and Division of Biostatistics, Washington University, St Louis, Mo (M.A.P.). * To whom correspondence should be addressed. E-mail: ldjousse{at}bu.edu.
Background--High dietary intake of linolenic acid is associated with a lower risk of cardiovascular disease mortality. However, little is known about the association between linolenic acid and subclinical atherosclerosis. Methods and Results--To examine the association between dietary linolenic acid measured by food frequency questionnaire and calcified atherosclerotic plaque in the coronary arteries (CAC) measured by cardiac CT, we studied 2004 white participants of the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study aged 32 to 93 years. The presence of CAC was defined on the basis of total CAC score of Conclusions--Consumption of dietary linolenic acid is associated with a lower prevalence of CAC in a dose-response fashion in white men and women.
Revised on February 3, 2005
Accepted on February 22, 2005
Dietary Linolenic Acid Is Inversely Associated With Calcified Atherosclerotic Plaque in the Coronary Arteries. The National Heart, Lung, and Blood Institute Family Heart Study
Luc Djoussé MD, DSc, MPH*,
100. We used generalized estimating equations to estimate odds ratios for the presence of CAC across quintiles of linolenic acid. The average consumption of dietary linolenic acid was 0.82±0.36 g/d for men and 0.69±0.29 g/d for women. From the lowest to the highest quintile of linolenic acid, adjusted odds ratios (95% CI) for the presence of CAC were 1.0 (reference), 0.61 (0.42 to 0.88), 0.55 (0.35 to 0.84), 0.57 (0.37 to 0.88), and 0.35 (0.22 to 0.55), respectively (P for trend <0.0001), after we controlled for age, gender, education, family risk group, smoking, fruit and vegetable intake, history of coronary artery disease, hypertension, diabetes mellitus, and statin use. When linolenic acid was used as a continuous variable, the multivariate adjusted odds ratio was 0.38 (95% CI, 0.24 to 0.46) per gram of linolenic acid intake. Use of different cut points for CAC score yielded similar results.
Key words: diet • atherosclerosis • calcium • plaque • cardiovascular diseases
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Circulation 2005 111: 2872-2874.
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