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(Circulation. 1999;99:2709-2712.)
© 1999 American Heart Association, Inc.

Correspondence

Fibroelastoma and Embolic Stroke

John P. Veinot, MD

Laboratory Medicine Ottawa Civic Hospital, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

To the Editor:

Conte and Katz¹ recently provided images of a mitral valve papillary fibroelastoma detected by transesophageal echocardiogram. The patient presented with an embolic stroke, and the tumor was removed surgically. The authors postulated that a tumor fragment was responsible for the embolic event. This deserves comment because there is another possibility, potentially important for patient management.

Papillary fibroelastomas are benign cardiac tumors, usually located on valves, thought to be related to Lambl's excrescences. They may be incidental findings at surgery or autopsy, or clinically they have been associated with neurological events, stroke, angina, myocardial infarction, or sudden death.^{2 3} These events are thought to be related to emboli or to tumor obstruction of a coronary artery ostium.

Unlike myxoma, another common benign cardiac tumor that may be valvular and associated with similar clinical events, fragments of the tumor have only rarely been found in the arteries involved.^{2 3 4} It is more likely that the embolic material is fibrin or thrombus originating from the tumor surface. This probably relates to local trauma and endothelial damage at the tumor surface.^{3 4 5}

These tumors are composed of papillary fronds of collagen and elastin covered by endothelial cells. They are firmly attached to the valve. By pathological examination, it may be necessary to examine multiple slides of the tumor, but not uncommonly, small fragments of adherent fibrin and thrombus are found.

This is of clinical importance because some authors have proposed that as an alternative to surgical excision with valve repair or replacement, the tumors . . . [Full Text of this Article]

Alan S. Katz, MD

The Miriam Hospital Division of Cardiology

Frank J. Conte, MD

Providence, RI

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