Circulation. 1998;98:1477-1478
(Circulation. 1998;98:1477-1478.)
© 1998 American Heart Association, Inc.
From the Microscope to the Clinic
MR Assessment of Atherosclerotic Plaque
Gerald M. Pohost, MD;
; Anthon R. Fuisz, MD
From the University of Alabama at Birmingham.
Correspondence to Gerald M. Pohost, MD, BDB 101 Diabetes Research and Education Bldg, 1808 Seventh Ave S, Birmingham, AL 35294-0012. E-mail gpohost@uab.edu
Key Words: Editorials • atherosclerosis • plaque • magnetic resonance
Magnetic resonance is
the newest of the clinical imaging technologies to evaluate the
cardiovascular system. The ability to image the aorta
and the ileofemoral and carotid arteries is now a clinical reality.
Imaging of the large epicardial coronary arteries is rapidly
developing as a clinical tool. The next step will be to characterize
atherosclerotic plaque in vivo in larger vessels and then, potentially,
in human coronary arteries. In this issue of
Circulation, Fayad et al1 take a step
forward in the imaging of atherosclerotic plaque by MR. They report on
their experience with high-field MRI of "magnetic resonance
microscopy" in small mice, some of which were "wild-type"
controls and others genetically engineered to produce severe
atherosclerosis (apolipoprotein E knockout). Using
commonly available NMR hardware, the investigators were able to
visualize aortas with a total area of 0.3
mm2 in wild-type mice and 0.6
mm2 in the apolipoprotein E–knockout mice. To
image such small structures, they achieved a spatial resolution of
47 µm per pixel. MR measurements of wall area versus
histopathology correlated well (slope=1, r=0.86). In
addition, the grading of lesion shape and type from MR images also
correlated well with that by histopathology (r=0.91 and
r=0.90, respectively). Correlations of linear
regression analysis of MR and histopathology gradings of
atherosclerotic severity also were good (slope=0.64, r=0.90,
n=58).
Of course, the ideal model for human
atherosclerosis is Homo sapiens, and the
versatility of NMR methods allows such studies to be performed in
humans. Thus, . . . [Full Text of this Article]
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