From the Division of Cardiology, Kumamoto University School of Medicine,
Kumamoto, Japan.
Correspondence to Kiyotaka Kugiyama, MD, Division of Cardiology, Kumamoto University School of Medicine, Honjo 1–1-1, Kumamoto City, Japan 860-8556. E-mail kiyo{at}gpo.kumamoto-u.ac.jp
Abstract
Background—Oxygen free radicals have
been shown to cause endothelial vasomotor dysfunction.
This study examined the effect of reduced glutathione (GSH), an
antioxidant, on human coronary circulation.
Methods and Results—Responses of epicardial diameter and blood
flow of the left anterior descending coronary artery to
intracoronary infusion of acetylcholine (ACh, 50 µg/min) were
measured by quantitative coronary angiography and Doppler
flow-wire technique, respectively, before and during combined
intracoronary infusion of GSH (50 mg/min) or saline in 26
subjects with no significant coronary stenosis. GSH
infusion suppressed the constrictor response of epicardial diameter to
ACh and enhanced the increase in blood flow response to ACh.
Furthermore, GSH potentiated the coronary dilator effect of
nitroglycerin. A beneficial effect of GSH on the
epicardial diameter response to ACh was observed in a subgroup of
subjects with
Conclusions—The results indicate that GSH improved
coronary endothelial vasomotor function,
particularly in subjects with coronary risk factors, and it
potentiated the vasodilator effect of nitroglycerin in
human coronary arteries.
© 1998 American Heart Association, Inc.
Brief Rapid Communication
Intracoronary Infusion of Reduced Glutathione Improves Endothelial Vasomotor Response to Acetylcholine in Human Coronary Circulation
1 coronary risk factors but not in a subgroup
without risk factors. Saline infusion did not have any effects.
Key Words: antioxidants • free radicals • endothelium-derived factors • acetylcholine
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