(Circulation. 1997;96:1424-1431.)
© 1997 American Heart Association, Inc.
Articles |
Association of the Platelet PlA Polymorphism of Glycoprotein IIb/IIIa and the Fibrinogen Bß 448 Polymorphism With Myocardial Infarction and Extent of Coronary Artery Disease
From the Unit of Molecular Vascular Medicine, Research School of Medicine, University of Leeds, Leeds General Infirmary, Leeds, and the Department of Cardiology (I.J.W.), Pinderfields Hospital, Wakefield, UK.
Correspondence to Angela M. Carter, Unit of Molecular Vascular Medicine, Research School of Medicine, G Floor, Martin Wing, General Infirmary at Leeds, Leeds LS1 3EX UK. E-mail Medamc{at}Medphysics.Leeds.ac.UK
Background Platelets and fibrinogen play an integral role in the development of thrombosis and are implicated in the process of atherosclerosis. The fibrinogen Bß 448 polymorphism and the PlA polymorphism of platelet glycoprotein IIIa are reported to be independently associated with coronary artery disease. The aim of this study was to determine the association of the fibrinogen Bß 448 and the platelet glycoprotein IIIa PlA polymorphisms in relation to extent of coronary atheroma as characterized by angiography and a past history of myocardial infarction (MI) as assessed by World Health Organization criteria.
Methods and Results Caucasian patients (n=405) admitted for routine angiography for investigation of chest pain or suspected coronary artery disease were recruited. Caucasian control subjects (n=216) were recruited from local Family Health Services Authority general practice registers. Fibrinogen levels were higher (P=.04) in male patients (3.24 g/L; CI, 3.14 to 3.35) than male control subjects (3.06 g/L; CI, 2.91 to 3.21). There was a trend toward a difference (P=.06) in fibrinogen genotype distributions between female patients (1/1=93, 1/2=31, and 2/2=1) and female control subjects (1/1=67, 1/2=34, and 2/2=5). In logistic regression models the PlA2 genotype was associated with MI (odds ratio, 1.66; CI, 1.15 to 2.39; P=.007) and stenosis of more than one vessel (odds ratio, 1.5; CI, 1.01 to 2.26; P=.04). In men suffering an MI before the age of 47 years there was a 50% incidence of the PlA2 allele (P=.05), and in these subjects there was evidence of an interaction with cholesterol (P=.04).
Conclusions We found evidence of an association of the PlA2 polymorphism in MI and multiple-vessel stenosis. The association with MI was strongest in young men, in whom there was also evidence of an interaction with cholesterol.
Key Words: myocardial infarction • molecular biology • platelets • stenosis
This article has been cited by other articles:
 |
|
 |
|
  W. Koch, P. Hoppmann, J. Biele, J. C. Mueller, A. Schomig, and A. Kastrati Fibrinogen Genes and Myocardial Infarction: A Haplotype Analysis Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 758 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Wiwanitkit PIA1/A2 Polymorphism of the Platelet Glycoprotein Receptor IIb/IIIIa and Its Correlation With Myocardial Infarction: An Appraisal Clinical and Applied Thrombosis/Hemostasis, January 1, 2006; 12(1): 93 - 95. [Abstract] [PDF]
|
|
|
|
|
|
P. Kubisz, J. Ivankova, P. Holly, J. Stasko, and J. Musia/l The Glycoprotein IIIa PLA1/A2 Polymorphism--A Defect Responsible for the Sticky Platelet Syndrome? Clinical and Applied Thrombosis/Hemostasis, January 1, 2006; 12(1): 117 - 119. [PDF]
|
|
|
|
|
|
J. Mikkelsson, M. Perola, and P. J. Karhunen Genetics of Platelet Glycoprotein Receptors: Risk of Thrombotic Events and Pharmacogenetic Implications Clinical and Applied Thrombosis/Hemostasis, April 1, 2005; 11(2): 113 - 125. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Slowik, T. Dziedzic, W. Turaj, J. Pera, L. Glodzik-Sobanska, P. Szermer, M. T. Malecki, D. A. Figlewicz, and A. Szczudlik A2 Alelle of GpIIIa Gene Is a Risk Factor for Stroke Caused by Large-Vessel Disease in Males Stroke, July 1, 2004; 35(7): 1589 - 1593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J J McCarthy, A Parker, R Salem, D J Moliterno, Q Wang, E F Plow, S Rao, G Shen, W J Rogers, L K Newby, et al. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes J. Med. Genet., May 1, 2004; 41(5): 334 - 341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Voetsch and J. Loscalzo Genetic Determinants of Arterial Thrombosis Arterioscler. Thromb. Vasc. Biol., February 1, 2004; 24(2): 216 - 229. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. B. Braunstein, D. W. Kershner, P. Bray, G. Gerstenblith, S. P. Schulman, W. S. Post, and R. S. Blumenthal Interaction of Hemostatic Genetics With Hormone Therapy : New Insights To Explain Arterial Thrombosis in Postmenopausal Women Chest, March 1, 2002; 121(3): 906 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Benze, J. Heinrich, H. Schulte, S. Rust, U. Nowak-Gottl, M.-C. Tataru, E. Kohler, G. Assmann, and R. Junker Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men Eur. Heart J., February 2, 2002; 23(4): 325 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. F. O'Connor, D. C. Shields, A. Fitzgerald, C. P. Cannon, E. Braunwald, and D. J. Fitzgerald Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes Blood, December 1, 2001; 98(12): 3256 - 3260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. P. Agema, J. W. Jukema, S. N. Pimstone, and J. J. P. Kastelein Genetic aspects of restenosis after percutaneous coronary interventions;towards more tailored therapy Eur. Heart J., November 2, 2001; 22(22): 2058 - 2074. [PDF]
|
|
|
|
 |
|
 D. Feng, K. Lindpaintner, M. G. Larson, C. J. O'Donnell, I. Lipinska, P. A. Sutherland, M. Mittleman, J. E. Muller, R. B. D'Agostino, D. Levy, et al. Platelet Glycoprotein IIIa PlA Polymorphism, Fibrinogen, and Platelet Aggregability: The Framingham Heart Study Circulation, July 10, 2001; 104(2): 140 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.R. GREEN Fibrinogen Polymorphisms and Atherothrombotic Disease Ann. N.Y. Acad. Sci., June 1, 2001; 936(1): 549 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Bennett, F. Catella-Lawson, A. R. Rut, G. Vilaire, W. Qi, S. C. Kapoor, S. Murphy, and G. A. FitzGerald Effect of the PlA2 alloantigen on the function of {beta}3-integrins in platelets Blood, May 15, 2001; 97(10): 3093 - 3099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Williams and P. F. Bray Genetics of Arterial Prothrombotic Risk States Experimental Biology and Medicine, May 1, 2001; 226(5): 409 - 419. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. J. Lefkowitz and J. T. Willerson Prospects for Cardiovascular Research JAMA, February 7, 2001; 285(5): 581 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Mathew, C. S. Rinder, J. G. Howe, M. Fontes, J. Crouch, M. F. Newman, B. Phillips-Bute, and B. R. Smith Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass Ann. Thorac. Surg., February 1, 2001; 71(2): 663 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Aleksic, H. Juneja, A. R. Folsom, C. Ahn, E. Boerwinkle, L. E. Chambless, and K. K. Wu Platelet PlA2 Allele and Incidence of Coronary Heart Disease : Results From the Atherosclerosis Risk In Communities (ARIC) Study Circulation, October 17, 2000; 102(16): 1901 - 1905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mikkelsson, M. Perola, P. Laippala, A. Penttila, and P. J. Karhunen Glycoprotein IIIa PlA1/A2 polymorphism and sudden cardiac death J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1317 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kastrati, W. Koch, M. Gawaz, J. Mehilli, C. Bottiger, K. Schomig, N. von Beckerath, and A. Schomig PlA polymorphism of glycoprotein IIIa and risk of adverse events after coronary stent placement J. Am. Coll. Cardiol., July 1, 2000; 36(1): 84 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Collet, D. Park, C. Lesty, J. Soria, C. Soria, G. Montalescot, and J. W. Weisel Influence of Fibrin Network Conformation and Fibrin Fiber Diameter on Fibrinolysis Speed : Dynamic and Structural Approaches by Confocal Microscopy Arterioscler. Thromb. Vasc. Biol., May 1, 2000; 20(5): 1354 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Lane and P. J. Grant Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease Blood, March 1, 2000; 95(5): 1517 - 1532. [Full Text] [PDF]
|
|
|
|
|
|
A. M. Carter, A. J. Catto, J. M. Bamford, and P. J. Grant Association of the Platelet Glycoprotein IIb HPA-3 Polymorphism With Survival After Acute Ischemic Stroke Stroke, December 1, 1999; 30(12): 2606 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. C. Hooper, C. Lally, H. Austin, J. Benson, A. Dilley, N. K. Wenger, C. Whitsett, P. Rawlins, and B. L. Evatt The Relationship Between Polymorphisms in the Endothelial Cell Nitric Oxide Synthase Gene and the Platelet GPIIIa Gene With Myocardial Infarction and Venous Thromboembolism in African Americans Chest, October 1, 1999; 116(4): 880 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mikkelsson, M. Perola, P. Laippala, V. Savolainen, J. Pajarinen, K. Lalu, A. Penttila, and P. J. Karhunen Glycoprotein IIIa PlA Polymorphism Associates With Progression of Coronary Artery Disease and With Myocardial Infarction in an Autopsy Series of Middle-Aged Men Who Died Suddenly Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2573 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Feng, K. Lindpaintner, M. G. Larson, V. S. Rao, C. J. O'Donnell, I. Lipinska, C. Schmitz, P. A. Sutherland, H. Silbershatz, R. B. D'Agostino, et al. Increased Platelet Aggregability Associated With Platelet GPIIIa PlA2 Polymorphism : The Framingham Offspring Study Arterioscler. Thromb. Vasc. Biol., April 1, 1999; 19(4): 1142 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kastrati, A. Schomig, M. Seyfarth, W. Koch, S. Elezi, C. Bottiger, J. Mehilli, K. Schomig, and N. von Beckerath PlA Polymorphism of Platelet Glycoprotein IIIa and Risk of Restenosis After Coronary Stent Placement Circulation, March 2, 1999; 99(8): 1005 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gonzalez-Conejero, M. L. Lozano, J. Rivera, J. Corral, J. A. Iniesta, J. M. Moraleda, and V. Vicente Polymorphisms of Platelet Membrane Glycoprotein Ibalpha Associated With Arterial Thrombotic Disease Blood, October 15, 1998; 92(8): 2771 - 2776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Batalla, G. I. Cubero, J. R. Reguero, E. Coto, A. M. Carter, and B. P. J. Grant Platelet PlA Polymorphism, Myocardial Infarction, and Extent of Coronary Artery Disease • Response Circulation, August 25, 1998; 98(8): 826 - 827. [Full Text]
|
|
|
|
|
|
A. M. Carter, A. J. Catto, J. M. Bamford, and P. J. Grant Platelet GP IIIa PlA and GP Ib Variable Number Tandem Repeat Polymorphisms and Markers of Platelet Activation in Acute Stroke Arterioscler. Thromb. Vasc. Biol., July 1, 1998; 18(7): 1124 - 1131. [Abstract] [Full Text] [PDF]
|
|