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(Circulation. 1997;96:3687-3695.)
© 1997 American Heart Association, Inc.

Articles

Direct Measurement of Three-dimensionally Reconstructed Flow Convergence Surface Area and Regurgitant Flow in Aortic Regurgitation

In Vitro and Chronic Animal Model Studies

Takahiro Shiota, MD; Michael Jones, MD; Alain Delabays, MD; Xiaokui Li, MD; Izumi Yamada, MD; Masahiro Ishii, MD; Philippe Acar, MD; Scott Holcomb, MS; Natesa G. Pandian, MD; ; David J. Sahn, MD

From The Clinical Care Center for Congenital Heart Disease, Oregon Health Sciences University, Portland (T.S., X.L.,M.I., S.H., D.J.S.); the Laboratory of Animal Medicine and Surgery, NHLBI, Bethesda, Md (M.J., I.Y.); and Non-invasive Cardiac Laboratory, Tufts-New England Medical Center, Boston, Mass (A.D., P.A., N.G.P.).

Background Evaluation of flow convergence (FC) with two-dimensional (2D) imaging systems may not be sufficiently accurate to characterize these often asymmetric, complex phenomena. The aim of this study was to validate a three-dimensional (3D) method for determining the severity of aortic regurgitation (AR) in an experimental animal model.

Methods and Results In six sheep with surgically induced chronic AR, 20 hemodynamically different states were studied. Instantaneous regurgitant flow rates were obtained by aortic and pulmonary electromagnetic flow meters. Video composite data of color Doppler flow mapping images were transferred into a TomTec computer after computer-controlled 180° rotational acquisition. Direct measurement of the 3D reconstructed FC surface areas as well as measurements of FC areas estimated with 2D methods with hemispherical and hemielliptical assumptions were performed, and values were multiplied by the aliasing velocity to obtain peak regurgitant flow rates. There was better agreement between 3D and electromagnetically derived flow rates than there was between the 2D and the reference values (r=.94, y=1.0x-0.16, difference=0.02 L/min for the 3D method; r=.80, y=1.6x-0.3, difference=1.2 L/min for the 2D hemispherical method; r=.75, y=0.90x+0.2, difference=-0.20 L/min for the 2D hemielliptical method).

Conclusions Without any geometrical assumption, the 3D method provided better delineation of the FC zones and direct measurements of FC surface areas, permitting more accurate quantification of the severity of AR than the 2D methods.

Key Words: regurgitation • echocardiography • blood flow • Doppler analysis

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