| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 1997;95:917-923.)
© 1997 American Heart Association, Inc.
Articles |
Effects of Aging on Left Ventricular Relaxation in Humans
Analysis of Left Ventricular Isovolumic Pressure Decay
The First Department of Internal Medicine and the Department of Pathology (K.I.-Y.), Mie University, Tsu, Japan.
Correspondence to Tetsu Yamakado, MD, The First Department of Internal Medicine, Mie University, 2-174 Edobashi, Tsu 514, Japan. E-mail yamakado@clin.medic.mie-u.ac.jp.
Background Some experimental studies in animals have shown that myocardial relaxation is prolonged with aging. However, it is not known whether aging alters ventricular isovolumic relaxation in human subjects.
Methods and Results We analyzed high-fidelity left ventricular pressures, measured by use of a catheter-tipped manometer, and biplane left ventriculograms in 55 normal subjects who underwent diagnostic cardiac catheterization but who were found to have normal cardiac anatomy and function. There were 38 men and 17 women, ranging in age from 20 to 77 years. Left ventricular isovolumic relaxation was assessed by the exponential time constants of isovolumic pressure decay with (Tb) and without (Tw) an asymptote pressure. Left ventricular volume, ejection fraction, and wall thickness or mass were calculated from left ventricular angiograms. Neither of the time constants of left ventricular relaxation correlated with age (Tb: r=.001 to .10, P=NS; Tw: r=.02 to .05, P=NS). Left ventricular systolic function (ie, ejection fraction and end-systolic volume index), heart rate, and left ventricular wall thickness or mass, which are major hemodynamic determinants of left ventricular relaxation, were not significantly affected by aging. The multivariate analysis of age and hemodynamic variables against the time constants of left ventricular relaxation also indicated that no significant relation was found between age and left ventricular relaxation.
Conclusions In the absence of coronary artery disease, systemic hypertension, left ventricular systolic dysfunction, or hypertrophy, left ventricular relaxation assessed by the time constant of isovolumic pressure decay remains essentially unchanged with normal adult aging, at least until the eighth decade.
Key Words: myocardial relaxation • aging • pressure • hemodynamics
This article has been cited by other articles:
 |
|
 |
|
  B. T. Esch, J. M. Scott, D. E.R. Warburton, R. Thompson, D. Taylor, J. C. Baron, I. Paterson, and M. J. Haykowsky Left ventricular torsion and untwisting during exercise in heart transplant recipients J. Physiol., May 15, 2009; 587(10): 2375 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Bukachi, A. Waldenstrom, S. Morner, P. Lindqvist, M.Y. Henein, and E. Kazzam Age dependency in the timing of mitral annular motion in relation to ventricular filling in healthy subjects: Umea General Population Heart Study Eur J Echocardiogr, July 1, 2008; 9(4): 522 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Paulus, C. Tschope, J. E. Sanderson, C. Rusconi, F. A. Flachskampf, F. E. Rademakers, P. Marino, O. A. Smiseth, G. De Keulenaer, A. F. Leite-Moreira, et al. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology Eur. Heart J., October 2, 2007; 28(20): 2539 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lumens, T. Delhaas, T. Arts, B. R. Cowan, and A. A. Young Impaired subendocardial contractile myofiber function in asymptomatic aged humans, as detected using MRI Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1573 - H1579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Notomi, G. Srinath, T. Shiota, M. G. Martin-Miklovic, L. Beachler, K. Howell, S. J. Oryszak, D. G. Deserranno, A. D. Freed, N. L. Greenberg, et al. Maturational and Adaptive Modulation of Left Ventricular Torsional Biomechanics: Doppler Tissue Imaging Observation From Infancy to Adulthood Circulation, May 30, 2006; 113(21): 2534 - 2541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Hees, J. L. Fleg, Z. A. Mirza, S. Ahmed, C. O. Siu, and E. P. Shapiro Effects of Normal Aging on Left Ventricular Lusitropic, Inotropic, and Chronotropic Responses to Dobutamine J. Am. Coll. Cardiol., April 4, 2006; 47(7): 1440 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. B. Popovic, A. Prasad, M. J. Garcia, A. Arbab-Zadeh, A. Borowski, E. Dijk, N. L. Greenberg, B. D. Levine, and J. D. Thomas Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1454 - H1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Redfield, S. J. Jacobsen, B. A. Borlaug, R. J. Rodeheffer, and D. A. Kass Age- and Gender-Related Ventricular-Vascular Stiffening: A Community-Based Study Circulation, October 11, 2005; 112(15): 2254 - 2262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Prasad, K. Okazaki, A. A. Zadeh, E. Dijk, Q. Fu, J. D. Thomas, and B. D. Levine Abnormalities of Doppler Measures of Diastolic Function in the Healthy Elderly Are Not Related to Alterations of Left Atrial Pressure Circulation, March 29, 2005; 111(12): 1499 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Hees, J. L. Fleg, S.-J. Dong, and E. P. Shapiro MRI and echocardiographic assessment of the diastolic dysfunction of normal aging: altered LV pressure decline or load? Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H782 - H788. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Oxenham and N. Sharpe Cardiovascular aging and heart failure Eur J Heart Fail, August 1, 2003; 5(4): 427 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. F. Bronzwaer, C. Heymes, C. A. Visser, and W. J. Paulus Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H10 - H16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. De Mey, J. D. Thomas, N. L. Greenberg, P. M. Vandervoort, and P. R. Verdonck Assessment of the time constant of relaxation: insights from simulations and hemodynamic measurements Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2936 - H2943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Lorell and B. A. Carabello Left Ventricular Hypertrophy : Pathogenesis, Detection, and Prognosis Circulation, July 25, 2000; 102(4): 470 - 479. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Asif, J. Egan, S. Vasan, G. N. Jyothirmayi, M. R. Masurekar, S. Lopez, C. Williams, R. L. Torres, D. Wagle, P. Ulrich, et al. An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness PNAS, March 14, 2000; 97(6): 2809 - 2813. [Abstract] [Full Text] [PDF]
|
|