(Circulation. 1997;95:2471.)
© 1997 American Heart Association, Inc.
Articles |
Is Hepatocyte Growth Factor a Protein With Cardioprotective Activity in the Ischemic Heart?
the Max-Planck-Institute, Department of Experimental Cardiology, Bad Nauheim, Germany.
Correspondence to Wolfgang Schaper, MD, PhD, Max-Planck-Institute, Department of Experimental Cardiology, Benekestr 2, D-61231 Bad Nauheim, Germany.
Key Words: Editorials • hepatocyte growth factor • myocardial infarction • ischemia
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
During the past 15 years, hepatocyte growth factor (HGF) and its receptor have been the subject of immense research efforts. The activity of HGF was first demonstrated in the serum of normal and partially hepatectomized rats by Strain et al1 and Michalopoulos et al2 in 1982. During the years 1984 to 1988, Gohda et al3 , Nakamura et al,4 Russell et al,5 and Thaler and Michalopoulos6 independently isolated and purified HGF from different sources, including platelets and serum (the history of the discovery, purification cloning, and functions of HGF are excellently reviewed by Gohda et al7 and Matsumoto and Nakamura.8 ). At that time, HGF was regarded as a growth factor specific to hepatocytes, and most researchers focused mainly on the growth of cultured hepatocytes and liver regeneration. By 1990 or 1991, the importance of HGF entered a new dimension when it was shown that HGF was identical to the scatter factor (SF),9 the fibroblast-derived tumor cytotoxic factor (F-TCF),10 and a fibroblast-derived epithelial morphogen.11 Around the same time, the HGF receptor was identified as the c-met proto-oncogene product.12 13 It became clear that HGF/SF/F-TCF is a multipotent growth factor whose receptor is not only expressed in the normal epithelium of almost every tissue but also in different cell types such as melanocytes, endothelial cells, microglial cells, neurons, hemopoietic cells, and a variety of tumor cell lines of various origins that are also targets of this growth factor.8 The general activities of HGF were found to be mitogenesis, motogenesis (enhancement of
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