(Circulation. 1996;94:3341-3347.)
© 1996 American Heart Association, Inc.
Articles |
Nitric Oxide Attenuates the Release of Endothelium-Derived Hyperpolarizing Factor
the Zentrum der Physiologie, Klinikum der Johann Wolfgang Goethe-Universitat, Frankfurt am Main, Germany.
Correspondence to Dr Johann Bauersachs, Zentrum der Physiologie, Klinikum der Johann Wolfgang Goethe-Universitat, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
Background The contribution of the endothelium-derived hyperpolarizing factor (EDHF), proposed to be a cytochrome P450–derived metabolite of arachidonic acid, to endothelium-dependent dilatation under physiological conditions has yet to be established, because its effect can be detected only after inhibition of NO synthase and cyclooxygenase. The possibility that NO exerts a feedback inhibition on EDHF formation was studied in isolated perfused arterial segments.
Methods and Results Under combined blockade of NO synthase and cyclooxygenase, the EDHF-mediated vasodilatation elicited by receptor-dependent agonists in rabbit carotid and porcine coronary arteries was significantly attenuated by the NO donors C87-3786 and CAS 1609. The endothelium-independent dilatation elicited by isoproterenol was not altered by either NO donor. In NG-nitro-L-arginine–treated carotid artery segments, C87-3786 significantly attenuated the acetylcholine-induced increase in 6-keto-prostaglandin F1
release, which was taken as an index of arachidonic acid liberation. In parallel experiments using cultured human endothelial cells, C87-3786 attenuated the Ca2+ response to bradykinin. The release of EDHF from a luminally perfused porcine coronary artery was detected by recording the membrane potential of downstream-situated cultured rat aortic smooth muscle cells. The NO donor C87-3786 had no effect on the hyperpolarization elicited by preformed EDHF but markedly inhibited its release from bradykinin-stimulated donor segments.
Conclusions These findings indicate that under physiological conditions, the production of EDHF is damped by NO. Therefore, it follows that when NO synthesis is impaired, alleviation of this intrinsic inhibition may, at least in part, maintain endothelial vasodilator function.
Key Words: endothelium-derived factors • vasodilation • calcium • acetylcholine • bradykinin
This article has been cited by other articles:
 |
|
 |
|
  F. Krotz, N. Hellwig, M. A. Burkle, S. Lehrer, T. Riexinger, H. Mannell, H.-Y. Sohn, V. Klauss, and U. Pohl A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo Cardiovasc Res, October 4, 2009; (2009) cvp301v2. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rudolph and B. A. Freeman Cardiovascular Consequences When Nitric Oxide and Lipid Signaling Converge Circ. Res., September 11, 2009; 105(6): 511 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. C. Hercule, W.-H. Schunck, V. Gross, J. Seringer, F. P. Leung, S. M. Weldon, A. Ch. da Costa Goncalves, Y. Huang, F. C. Luft, and M. Gollasch Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice Arterioscler Thromb Vasc Biol, January 1, 2009; 29(1): 54 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Graier and M. Hecker Endothelial H2O2: A Bad Guy Turning Good? Arterioscler Thromb Vasc Biol, October 1, 2008; 28(10): 1691 - 1693. [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Edgley, M. Tare, R. G. Evans, C. Skordilis, and H. C. Parkington In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R829 - R839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J Dietze and E. J Henriksen Review: Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis Journal of Renin-Angiotensin-Aldosterone System, June 1, 2008; 9(2): 75 - 88. [Abstract] [PDF]
|
|
|
|
 |
|
 I. C Villar, A. J Hobbs, and A. Ahluwalia Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor J. Endocrinol., June 1, 2008; 197(3): 447 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Mishra, S. Tripathy, K. M. Desai, D. Quest, Y. Lu, J. Akhtar, and V. Gopalakrishnan Nitric Oxide Synthase Inhibition Promotes Endothelium-Dependent Vasodilatation and the Antihypertensive Effect of L-Serine Hypertension, March 1, 2008; 51(3): 791 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Saliez, C. Bouzin, G. Rath, P. Ghisdal, F. Desjardins, R. Rezzani, L.F. Rodella, J. Vriens, B. Nilius, O. Feron, et al. Role of Caveolar Compartmentation in Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation: Ca2+ Signals and Gap Junction Function Are Regulated by Caveolin in Endothelial Cells Circulation, February 26, 2008; 117(8): 1065 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Larsen, D. D. Gutterman, A. Sato, K. Toyama, W. B. Campbell, D. C. Zeldin, V. L. Manthati, J. R. Falck, and H. Miura Hydrogen Peroxide Inhibits Cytochrome P450 Epoxygenases: Interaction Between Two Endothelium-Derived Hyperpolarizing Factors Circ. Res., January 4, 2008; 102(1): 59 - 67. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Gaubert, D. Sigaudo-Roussel, M. Tartas, G. Berrut, J. L. Saumet, and B. Fromy Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice J. Physiol., December 1, 2007; 585(2): 617 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lorenzo and C. T. Minson Human cutaneous reactive hyperaemia: role of BKCa channels and sensory nerves J. Physiol., November 15, 2007; 585(1): 295 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ide, M. Worthley, T. Anderson, and M. J. Poulin Effects of the nitric oxide synthase inhibitor L-NMMA on cerebrovascular and cardiovascular responses to hypoxia and hypercapnia in humans J. Physiol., October 1, 2007; 584(1): 321 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fischer, U. Landmesser, S. Spiekermann, D. Hilfiker-Kleiner, M. Hospely, M. Muller, R. Busse, I. Fleming, and H. Drexler Cytochrome P450 2C9 is involved in flow-dependent vasodilation of peripheral conduit arteries in healthy subjects and in patients with chronic heart failure Eur J Heart Fail, August 1, 2007; 9(8): 770 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Fitzgerald, B. K. Kemp-Harper, H. C. Parkington, G. A. Head, and R. G. Evans Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R707 - R713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Fitzgerald, H. Bashari, J. A. Cox, H. C. Parkington, and R. G. Evans Contributions of endothelium-derived relaxing factors to control of hindlimb blood flow in the mouse in vivo Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1072 - H1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. van Deel, D. Merkus, R. van Haperen, M. C. de Waard, R. de Crom, and D. J. Duncker Vasomotor control in mice overexpressing human endothelial nitric oxide synthase Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1144 - H1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Medow, I. Taneja, and J. M. Stewart Cyclooxygenase and nitric oxide synthase dependence of cutaneous reactive hyperemia in humans Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H425 - H432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Ingram, S. C. Newcomer, E. M. Price, K. E. Eklund, R. M. McAllister, and M. H. Laughlin Chronic nitric oxide synthase inhibition blunts endothelium-dependent function of conduit coronary arteries, not arterioles Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2798 - H2808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Campbell and J. R. Falck Arachidonic Acid Metabolites as Endothelium-Derived Hyperpolarizing Factors Hypertension, March 1, 2007; 49(3): 590 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, R.H. Henning, E. Lipsic, A. van Buiten, W.H. van Gilst, and H. Buikema Acetylcholine stimulated dilatation and stretch induced myogenic constriction in mesenteric artery of rats with chronic heart failure Eur J Heart Fail, February 1, 2007; 9(2): 144 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bellien, M. Iacob, L. Gutierrez, M. Isabelle, A. Lahary, C. Thuillez, and R. Joannides Crucial Role of NO and Endothelium-Derived Hyperpolarizing Factor in Human Sustained Conduit Artery Flow-Mediated Dilatation Hypertension, December 1, 2006; 48(6): 1088 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Rasmussen, P. M. Vanhoutte, B. L. Jensen, and O. Skott Continuous flow augments reactivity of rabbit carotid artery by reducing bioavailability of NO despite an increase in release of EDHF Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1521 - H1528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Kalliokoski, H. Langberg, A. K. Ryberg, C. Scheede-Bergdahl, S. Doessing, A. Kjaer, M. Kjaer, and R. Boushel Nitric oxide and prostaglandins influence local skeletal muscle blood flow during exercise in humans: coupling between local substrate uptake and blood flow Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R803 - R809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Taddei, D. Versari, A. Cipriano, L. Ghiadoni, F. Galetta, F. Franzoni, A. Magagna, A. Virdis, and A. Salvetti Identification of a Cytochrome P450 2C9-Derived Endothelium-Derived Hyperpolarizing Factor in Essential Hypertensive Patients J. Am. Coll. Cardiol., August 1, 2006; 48(3): 508 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shi, D. D. Ku, R. Y. K. Man, and P. M. Vanhoutte Augmented Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxations Attenuate Endothelial Dysfunction in Femoral and Mesenteric, but Not in Carotid Arteries from Type I Diabetic Rats J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 276 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. P. Hilgers, J. Todd Jr., and R. C. Webb Regional heterogeneity in acetylcholine-induced relaxation in rat vascular bed: role of calcium-activated K+ channels Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H216 - H222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bellien, R. Joannides, M. Iacob, P. Arnaud, and C. Thuillez Evidence for a basal release of a cytochrome-related endothelium-derived hyperpolarizing factor in the radial artery in humans Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1347 - H1352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Anderson, D. J. Martin, D. L. Phillips, K. J. Killpack, S. E. Bone, and R. Rahimian The influence of gender on parasympathetic vasodilatation in the submandibular gland of the rat Exp Physiol, March 1, 2006; 91(2): 435 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S D Robinson, C A Ludlam, N A Boon, and D E Newby Phosphodiesterase type 5 inhibition does not reverse endothelial dysfunction in patients with coronary heart disease Heart, February 1, 2006; 92(2): 170 - 176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. You, E. M. Golding, and R. M. Bryan Jr. Arachidonic acid metabolites, hydrogen peroxide, and EDHF in cerebral arteries Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1077 - H1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bellien, R. Joannides, M. Iacob, P. Arnaud, and C. Thuillez Calcium-Activated Potassium Channels and NO Regulate Human Peripheral Conduit Artery Mechanics Hypertension, July 1, 2005; 46(1): 210 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. G. Schrage, N. M. Dietz, J. H. Eisenach, and M. J. Joyner Agonist-dependent variablity of contributions of nitric oxide and prostaglandins in human skeletal muscle J Appl Physiol, April 1, 2005; 98(4): 1251 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Passauer, F. Pistrosch, E. Bussemaker, G. Lassig, K. Herbrig, and P. Gross Reduced Agonist-Induced Endothelium-Dependent Vasodilation in Uremia Is Attributable to an Impairment of Vascular Nitric Oxide J. Am. Soc. Nephrol., April 1, 2005; 16(4): 959 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Jung, R. P. Brandes, I.-H. Kim, F. Schweda, R. Schmidt, B. D. Hammock, R. Busse, and I. Fleming Soluble Epoxide Hydrolase Is a Main Effector of Angiotensin II-Induced Hypertension Hypertension, April 1, 2005; 45(4): 759 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Scotland, M. Madhani, S. Chauhan, S. Moncada, J. Andresen, H. Nilsson, A. J. Hobbs, and A. Ahluwalia Investigation of Vascular Responses in Endothelial Nitric Oxide Synthase/Cyclooxygenase-1 Double-Knockout Mice: Key Role for Endothelium-Derived Hyperpolarizing Factor in the Regulation of Blood Pressure in Vivo Circulation, February 15, 2005; 111(6): 796 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Hatoum, D. G. Binion, H. Miura, G. Telford, M. F. Otterson, and D. D. Gutterman Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H48 - H54. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Dinenno and M. J. Joyner Combined NO and PG inhibition augments {alpha}-adrenergic vasoconstriction in contracting human skeletal muscle Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2576 - H2584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Taylor, I. Y. Khan, M. A. Hanson, and L. Poston Impaired EDHF-mediated vasodilatation in adult offspring of rats exposed to a fat-rich diet in pregnancy J. Physiol., August 1, 2004; 558(3): 943 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Clifford and Y. Hellsten Vasodilatory mechanisms in contracting skeletal muscle J Appl Physiol, July 1, 2004; 97(1): 393 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takeuchi, H. Watanabe, Q.-K. Tran, M. Ozeki, D. Sumi, T. Hayashi, A. Iguchi, L. J Ignarro, K. Ohashi, and H. Hayashi Nitric oxide: inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression Cardiovasc Res, April 1, 2004; 62(1): 194 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Martinez-Orgado, R. Gonzalez, M. J. Alonso, and M. Salaices Impairment of Fetal Endothelium-Dependent Relaxation in a Rat Model of Preeclampsia by Chronic Nitric Oxide Synthase Inhibition Reproductive Sciences, February 1, 2004; 11(2): 82 - 88. [Abstract] [PDF]
|
|
|
|
|
|
S. Fichtlscherer, S. Dimmeler, S. Breuer, R. Busse, A. M. Zeiher, and I. Fleming Inhibition of Cytochrome P450 2C9 Improves Endothelium-Dependent, Nitric Oxide-Mediated Vasodilatation in Patients With Coronary Artery Disease Circulation, January 20, 2004; 109(2): 178 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, L. Lin, J. Jiang, Y. Wang, Z. Y. Lu, J. A. Bradbury, F. B. Lih, D. W. Wang, and D. C. Zeldin Up-Regulation of Endothelial Nitric-Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-Activated Protein Kinase and Protein Kinase C Signaling Pathways J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 753 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Xu, R. A. Santizo, V. L. Baughman, and D. A. Pelligrino Nascent EDHF-mediated cerebral vasodilation in ovariectomized rats is not induced by eNOS dysfunction Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2045 - H2053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. T. Udosen, H. Jiang, H. C. Hercule, and A. O. Oyekan Nitric oxide-epoxygenase interactions and arachidonate-induced dilation of rat renal microvessels Am J Physiol Heart Circ Physiol, November 1, 2003; 285(5): H2054 - H2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inokuchi, Y. Hirooka, H. Shimokawa, K. Sakai, T. Kishi, K. Ito, Y. Kimura, and A. Takeshita Role of Endothelium-Derived Hyperpolarizing Factor in Human Forearm Circulation Hypertension, November 1, 2003; 42(5): 919 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bussemaker, R. Popp, B. Fisslthaler, C. M. Larson, I. Fleming, R. Busse, and R. P. Brandes Aged Spontaneously Hypertensive Rats Exhibit a Selective Loss of EDHF-Mediated Relaxation in the Renal Artery Hypertension, October 1, 2003; 42(4): 562 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Niebauer, A. J. Maxwell, P. S. Lin, D. Wang, P. S. Tsao, and J. P. Cooke NOS inhibition accelerates atherogenesis: reversal by exercise Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H535 - H540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bussemaker, R. Popp, B. Fisslthaler, C.M. Larson, I. Fleming, R. Busse, and R.P. Brandes Hyperthyroidism enhances endothelium-dependent relaxation in the rat renal artery Cardiovasc Res, July 1, 2003; 59(1): 181 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. O. Farouque and I. T. Meredith Relative contribution of vasodilator prostanoids, NO, and KATP channels to human forearm metabolic vasodilation Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2405 - H2411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gschwend, R. H. Henning, D. de Zeeuw, and H. Buikema Coronary Myogenic Constriction Antagonizes EDHF-Mediated Dilation: Role of KCa Channels Hypertension, April 1, 2003; 41(4): 912 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hillig, P. Krustrup, I. Fleming, T. Osada, B. Saltin, and Y. Hellsten Cytochrome P450 2C9 plays an important role in the regulation of exercise-induced skeletal muscle blood flow and oxygen uptake in humans J. Physiol., January 1, 2003; 546(1): 307 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chauhan, A. Rahman, H. Nilsson, L. Clapp, R. MacAllister, and A. Ahluwalia NO contributes to EDHF-like responses in rat small arteries: a role for NO stores Cardiovasc Res, January 1, 2003; 57(1): 207 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gschwend, H. Buikema, G. Navis, R. H. Henning, D. de Zeeuw, and R. P. E. van Dokkum Endothelial Dilatory Function Predicts Individual Susceptibility to Renal Damage in the 5/6 Nephrectomized Rat J. Am. Soc. Nephrol., December 1, 2002; 13(12): 2909 - 2915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rossig, H. Li, B. Fisslthaler, C. Urbich, I. Fleming, U. Forstermann, A. M. Zeiher, and S. Dimmeler Inhibitors of Histone Deacetylation Downregulate the Expression of Endothelial Nitric Oxide Synthase and Compromise Endothelial Cell Function in Vasorelaxation and Angiogenesis Circ. Res., November 1, 2002; 91(9): 837 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Degenhardt, J. Jansen, R. Schulz, D. Sedding, R. Braun-Dullaeus, and K.-D. Schluter Mechanosensitive release of parathyroid hormone-related peptide from coronary endothelial cells Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1489 - H1496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Thomsen, I. Rubin, and M. Lauritzen NO- and non-NO-, non-prostanoid-dependent vasodilatation in rat sciatic nerve during maturation and developing experimental diabetic neuropathy J. Physiol., September 15, 2002; 543(3): 977 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Xu, R. A. Santizo, V. L. Baughman, and D. A. Pelligrino ADP-induced pial arteriolar dilation in ovariectomized rats involves gap junctional communication Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1082 - H1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Boushel, H. Langberg, C. Gemmer, J. Olesen, R. Crameri, C. Scheede, M. Sander, and M. Kjaer Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise J. Physiol., September 1, 2002; 543(2): 691 - 698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sato, H. Miura, Y. Liu, L. B. Somberg, M. F. Otterson, M. J. Demeure, W. J. Schulte, L. M. Eberhardt, F. R. Loberiza, I. Sakuma, et al. Effect of gender on endothelium-dependent dilation to bradykinin in human adipose microvessels Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H845 - H852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Schildmeyer and R. M. Bryan Jr. Effect of NO on EDHF response in rat middle cerebral arteries Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H734 - H738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kimura, A.-M. Jefferis, H. Watanabe, and J. Chin-Dusting Insulin Inhibits Acetylcholine Responses in Rat Isolated Mesenteric Arteries via a Non-Nitric Oxide Nonprostanoid Pathway Hypertension, January 1, 2002; 39(1): 35 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Huang, Y. Wu, D. Sun, A. Koller, and G. Kaley Effect of estrogen on flow-induced dilation in NO deficiency: role of prostaglandins and EDHF J Appl Physiol, December 1, 2001; 91(6): 2561 - 2566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H Traverse, Y. Chen, M. Crampton, S. Voss, and R. J Bache Increased extravascular forces limit endothelium-dependent and -independent coronary vasodilation in congestive heart failure Cardiovasc Res, December 1, 2001; 52(3): 454 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Xu, R. A. Santizo, H. M. Koenig, and D. A. Pelligrino Chronic estrogen depletion alters adenosine diphosphate-induced pial arteriolar dilation in female rats Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2105 - H2112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fleming Cytochrome P450 and Vascular Homeostasis Circ. Res., October 26, 2001; 89(9): 753 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Chilian and R. Koshida EDHF and NO: Different Pathways for Production--Similar Actions Circ. Res., October 12, 2001; 89(8): 648 - 649. [Full Text] [PDF]
|
|
|
|
|
|
C. L. Oltman, N. L. Kane, J. L. Fudge, N. L. Weintraub, and K. C. Dellsperger Endothelium-derived hyperpolarizing factor in coronary microcirculation: responses to arachidonic acid Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1553 - H1560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Marrelli Mechanisms of endothelial P2Y1- and P2Y2-mediated vasodilatation involve differential [Ca2+]i responses Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1759 - H1766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-W. He and Z.-G. Liu Comparison of Nitric Oxide Release and Endothelium-Derived Hyperpolarizing Factor-Mediated Hyperpolarization Between Human Radial and Internal Mammary Arteries Circulation, September 18, 2001; 104 (2009): I-344 - I-349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Campbell and D. R. Harder Prologue: EDHF-what is it? Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2413 - H2416. [Full Text] [PDF]
|
|
|
|
|
|
Y. Wu, A. Huang, D. Sun, J. R. Falck, A. Koller, and G. Kaley Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2456 - H2461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Huang, D. Sun, M. A. Carroll, H. Jiang, C. J. Smith, J. A. Connetta, J. R. Falck, E. G. Shesely, A. Koller, and G. Kaley EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2462 - H2469. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. J. Halcox, S. Narayanan, L. Cramer-Joyce, R. Mincemoyer, and A. A. Quyyumi Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2470 - H2477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Rastaldo, N. Paolocci, A. Chiribiri, C. Penna, D. Gattullo, and P. Pagliaro Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2823 - H2832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. H. Honing, P. Smits, P. J. Morrison, J. C. Burnett Jr, and T. J. Rabelink C-Type Natriuretic Peptide-Induced Vasodilation Is Dependent On Hyperpolarization in Human Forearm Resistance Vessels Hypertension, April 1, 2001; 37(4): 1179 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fleming, U. R. Michaelis, D. Bredenkotter, B. Fisslthaler, F. Dehghani, R. P. Brandes, and R. Busse Endothelium-Derived Hyperpolarizing Factor Synthase (Cytochrome P450 2C9) Is a Functionally Significant Source of Reactive Oxygen Species in Coronary Arteries Circ. Res., January 19, 2001; 88(1): 44 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Sobey Potassium Channel Function in Vascular Disease Arterioscler Thromb Vasc Biol, January 1, 2001; 21(1): 28 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Clark and L. C. Fuchs BKCa channels compensate for loss of NOS-dependent coronary artery relaxation in cardiomyopathy Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2598 - H2603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Jeremy and H. McCarron Effect of hypercholesterolemia on Ca2+-dependent K+ channel-mediated vasodilatation in vivo Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1600 - H1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Goto, K. Fujii, U. Onaka, I. Abe, and M. Fujishima Angiotensin-Converting Enzyme Inhibitor Prevents Age-Related Endothelial Dysfunction Hypertension, October 1, 2000; 36(4): 581 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P. Brandes, F.-H. Schmitz-Winnenthal, M. Feletou, A. Godecke, P. L. Huang, P. M. Vanhoutte, I. Fleming, and R. Busse An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice PNAS, August 15, 2000; 97(17): 9747 - 9752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishikawa, D. W. Stepp, and W. M. Chilian Nitric oxide exerts feedback inhibition on EDHF-induced coronary arteriolar dilation in vivo Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H459 - H465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Thorin, M. Lucas, P. Cernacek, and J. Dupuis Role of ETA receptors in the regulation of vascular reactivity in rats with congestive heart failure Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H844 - H851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fisslthaler, N. Hinsch, T. Chataigneau, R. Popp, L. Kiss, R. Busse, and I. Fleming Nifedipine Increases Cytochrome P4502C Expression and Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in Coronary Arteries Hypertension, August 1, 2000; 36(2): 270 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Vanheel and J. Van de Voorde EDHF and residual NO: different factors Cardiovasc Res, June 1, 2000; 46(3): 370 - 375. [Full Text] [PDF]
|
|
|
|
|
|
E. Thorin, D. Meerkin, O. F. Bertrand, P. Paiement, M. Joyal, and R. Bonan Influence of Postangioplasty {beta}-Irradiation on Endothelial Function in Porcine Coronary Arteries Circulation, March 28, 2000; 101(12): 1430 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. de Man, A. W. E. Weverling-Rijnsburger, A. van der Laarse, A. H. M. Smelt, J. W. Jukema, and G. J. Blauw Not Acute but Chronic Hypertriglyceridemia Is Associated With Impaired Endothelium-Dependent Vasodilation : Reversal After Lipid-Lowering Therapy by Atorvastatin Arterioscler Thromb Vasc Biol, March 1, 2000; 20(3): 744 - 750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Huang, D. Sun, C. J. Smith, J. A. Connetta, E. G. Shesely, A. Koller, and G. Kaley In eNOS knockout mice skeletal muscle arteriolar dilation to acetylcholine is mediated by EDHF Am J Physiol Heart Circ Physiol, March 1, 2000; 278(3): H762 - H768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Pelligrino, R. A. Santizo, and Q. Wang Miconazole represses CO2-induced pial arteriolar dilation only under selected circumstances Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1484 - H1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taddei, L. Ghiadoni, A. Virdis, S. Buralli, and A. Salvetti Vasodilation to Bradykinin Is Mediated by an Ouabain-Sensitive Pathway as a Compensatory Mechanism for Impaired Nitric Oxide Availability in Essential Hypertensive Patients Circulation, September 28, 1999; 100(13): 1400 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishikawa, D. W. Stepp, and W. M. Chilian In vivo location and mechanism of EDHF-mediated vasodilation in canine coronary microcirculation Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H1252 - H1259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sun, A. Huang, C. J. Smith, C. J. Stackpole, J. A. Connetta, E. G. Shesely, A. Koller, and G. Kaley Enhanced Release of Prostaglandins Contributes to Flow-Induced Arteriolar Dilation in eNOS Knockout Mice Circ. Res., August 6, 1999; 85(3): 288 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. da Silva-Santos and J. Assreuy Long-Lasting Changes of Rat Blood Pressure to Vasoconstrictors and Vasodilators Induced by Nitric Oxide Donor Infusion: Involvement of Potassium Channels J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 380 - 387. [Abstract] [Full Text]
|
|
|
|
|
|
A. S Izzard and A. M Heagerty Impaired flow-dependent dilatation in distal mesenteric arteries from the spontaneously hypertensive rat J. Physiol., July 1, 1999; 518(1): 239 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Malmsjo, A. Bergdahl, X.-H. Zhao, X.-Y. Sun, T. Hedner, L. Edvinsson, and D. Erlinge Enhanced acetylcholine and P2Y-receptor stimulated vascular EDHF-dilatation in congestive heart failure Cardiovasc Res, July 1, 1999; 43(1): 200 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kalliovalkama, P. Jolma, J.-P. Tolvanen, M. Kahonen, N. Hutri-Kahonen, X. Wu, P. Holm, and I. Porsti Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism Cardiovasc Res, June 1, 1999; 42(3): 773 - 782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kusterer, T. Pohl, H.-P. Fortmeyer, W. Marz, H. Scharnagl, A. Oldenburg, S. Angermuller, I. Fleming, K. H. Usadel, and R. Busse Chronic selective hypertriglyceridemia impairs endothelium-dependent vasodilatation in rats Cardiovasc Res, June 1, 1999; 42(3): 783 - 793. [Abstract] [Full Text] [PDF]
|
|