(Circulation. 1996;94:1-5.)
© 1996 American Heart Association, Inc.
Articles |
Meeting Highlights
American College of Cardiology 45th Annual Scientific Session, Orlando, Florida, March 24 to 27, 1996
St Luke's Episcopal Hospital, Texas Heart Institute, Baylor College of Medicine, University of Texas Health Science Center at Houston.
 |
GUSTO IIb |
|---|
Dr Frans Van de Werf, from the University Hospital Gasthuisberg in Leuven, Belgium, Drs Robert Califf and Christopher Granger from Duke University, Durham, NC, and Dr Eric Topol, from the Cleveland (Ohio) Clinic, presented the results of the GUSTO IIb study, a large, international, multicenter trial of heparin versus hirudin in patients with acute MI and unstable angina. A total of 12 142 qualifying patients (onset of symptoms within 12 hours and ischemic ECG changes) were stratified into two groups on the basis of whether or not ST-segment elevation was present and randomized to receive heparin or hirudin. The primary end point of the study was the 30-day incidence of death and MI. Because of prior experience with a high level of bleeding complications in GUSTO IIa, the doses of study drug (both heparin and hirudin) used in GUSTO IIb were significantly reduced from GUSTO IIa. Patients treated with hirudin were noted to require fewer adjustments to maintain therapeutic levels (a mean of two adjustments versus four with heparin), and there were more hirudin patients who did not require any dose adjustments (28.5% versus 5.4% with heparin). In the ST-segment elevation group (n=4131), there was marked benefit of hirudin at 24 hours in the incidence of death and MI but no significant differences between the hirudin and heparin groups in terms of severe bleeding events (1.1% with hirudin, 1.5% with heparin), stroke (1.3% with hirudin, 0.8% with heparin), death at 30 days (5.9% versus 6.3%), and reinfarction at 30 days
This article has been cited by other articles:
 |
|
 |
|
  C. Berry, K. S. Pieper, H. D. White, S. D. Solomon, F. Van de Werf, E. J. Velazquez, A. P. Maggioni, R. M. Califf, M. A. Pfeffer, and J. J.V. McMurray Patients with prior coronary artery bypass grafting have a poor outcome after myocardial infarction: an analysis of the VALsartan in acute myocardial iNfarcTion trial (VALIANT) Eur. Heart J., June 2, 2009; 30(12): 1450 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Z. Stepanovic, F. Potet, C. I. Petersen, J. A. Smith, J. Meiler, J. R. Balser, and S. Kupershmidt The evolutionarily conserved residue A653 plays a key role in HERG channel closing J. Physiol., June 1, 2009; 587(11): 2555 - 2566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W.W. Wong and K.-H. Mak Impact of Maze and Concomitant Mitral Valve Surgery on Clinical Outcomes Ann. Thorac. Surg., November 1, 2006; 82(5): 1938 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ozdemir, A. T. Sezgin, I. Barutcu, E. Topal, H. Gullu, and N. Acikgoz Comparison of Direct Stenting Versus Conventional Stent Implantation on Blood Flow in Patients With ST-Segment Elevation Myocardial Infarction Angiology, August 1, 2006; 57(4): 453 - 458. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Shoenfeld, R. Wu, L. D. Dearing, and E. Matsuura Are Anti-Oxidized Low-Density Lipoprotein Antibodies Pathogenic or Protective? Circulation, October 26, 2004; 110(17): 2552 - 2558. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Knaut, S. M. Tugtekin, F. Jung, and K. Matschke Microwave ablation for the surgical treatment of permanent atrial fibrillation--a single centre experience Eur. J. Cardiothorac. Surg., October 1, 2004; 26(4): 742 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wasson, H. K. Reddy, and M. L. Dohrmann Current Perspectives of Electrical Remodeling and Its Therapeutic Implications Journal of Cardiovascular Pharmacology and Therapeutics, April 1, 2004; 9(2): 129 - 144. [Abstract] [PDF]
|
|
|
|
 |
|
 A Wakai and J O O'Neill Emergency management of atrial fibrillation Postgrad. Med. J., June 1, 2003; 79(932): 313 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Collett, A. Wood, M. Y. Alexander, B. C. Varnum, R. P. Boot-Handford, V. Ohanian, J. Ohanian, Y.-W. Fridell, and A. E. Canfield Receptor Tyrosine Kinase Axl Modulates the Osteogenic Differentiation of Pericytes Circ. Res., May 30, 2003; 92(10): 1123 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. I. Pozeg, E. D. Michelakis, M. S. McMurtry, B. Thebaud, X.-C. Wu, J. R.B. Dyck, K. Hashimoto, S. Wang, R. Moudgil, G. Harry, et al. In Vivo Gene Transfer of the O2-Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats Circulation, April 22, 2003; 107(15): 2037 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Khairy and S. Nattel New insights into the mechanisms and management of atrial fibrillation Can. Med. Assoc. J., October 29, 2002; 167(9): 1012 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G. Sher, A. J. Bellg, L. Braun, A. Domas, R. Rosenson, and W. J. Canar Partners for Life: a theoretical approach to developing an intervention for cardiac risk reduction Health Educ. Res., October 1, 2002; 17(5): 597 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. F. Baker Jr Thrombolytic Therapy Clinical and Applied Thrombosis/Hemostasis, October 1, 2002; 8(4): 291 - 314. [PDF]
|
|
|
|
 |
|
 A. F. Le Blanche, M. Bonneau, M. Wassef, M.-T. Farres, L. Gabez, B. Aubert, M. Duriez, B. I. Levy, J.-M. Bigot, and F. Boudghene Histomorphometric Evaluation of 198Au Endovascular Brachytherapy in a Renal Artery Restenosis Model in Rabbits Am. J. Roentgenol., September 1, 2002; 179(3): 611 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zhang, K. Iwasaki, J. H Zuckerman, K. Behbehani, C. G Crandall, and B. D Levine Mechanism of blood pressure and R-R variability: insights from ganglion blockade in humans J. Physiol., August 15, 2002; 543(1): 337 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Luciardi, S. Berman, J. Muntaner, F. De La Serna, and R. Altman Facilitated Thrombolysis: Dethrombosis? Clinical and Applied Thrombosis/Hemostasis, April 1, 2002; 8(2): 133 - 138. [Abstract] [PDF]
|
|
|
|
|
|
J. A. Wolfe The coronary artery bypass conduit: II. Assessment of the quality of the distal anastomosis Ann. Thorac. Surg., December 1, 2001; 72(6): S2253 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C Maki, M. H Davidson, D. M Umporowicz, E. J Schaefer, M. R Dicklin, K. A Ingram, S. Chen, J. R McNamara, B. W Gebhart, J. D Ribaya-Mercado, et al. Lipid responses to plant-sterol-enriched reduced-fat spreads incorporated into a National Cholesterol Education Program Step I diet Am. J. Clinical Nutrition, July 1, 2001; 74(1): 33 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Carthey, M. R. de Leval, and J. T. Reason The human factor in cardiac surgery: errors and near misses in a high technology medical domain Ann. Thorac. Surg., July 1, 2001; 72(1): 300 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Gaballa, A. Eckhart, W. J. Koch, and S. Goldman Vascular {beta}-adrenergic receptor system is dysfunctional after myocardial infarction Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1129 - H1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Takach, G. J. Reul, I. Gregoric, Z. Krajcer, J. M. Duncan, J. J. Livesay, and D. A. Cooley Concomitant subclavian and coronary artery disease Ann. Thorac. Surg., January 1, 2001; 71(1): 187 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Priori, R. Bloise, and L. Crotti The long QT syndrome Europace, January 1, 2001; 3(1): 16 - 27. [PDF]
|
|
|
|
|
|
G. L. Pierpont, S. S. Chugh, J. A. Hauck, and C. C. Gornick Endocardial activation during ventricular fibrillation in normal and failing canine hearts Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1737 - H1747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vuksan, M. P Stavro, J. L Sievenpiper, V. Y. Koo, E. Wong, U. Beljan-Zdravkovic, T. Francis, A. L Jenkins, L. A Leiter, R. G Josse, et al. American Ginseng Improves Glycemia in Individuals with Normal Glucose Tolerance: Effect of Dose and Time Escalation J. Am. Coll. Nutr., June 1, 2000; 19(6): 738 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Elias, B. W. Patterson, and G. Schonfeld In Vivo Metabolism of ApoB, ApoA-I, and VLDL Triglycerides in a Form of Hypobetalipoproteinemia Not Linked to the ApoB Gene Arterioscler Thromb Vasc Biol, May 1, 2000; 20(5): 1309 - 1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Geremia, T. Brack, L. Brennecke, M. Haklin, and R. Falter Occlusion of Experimentally Created Fusiform Aneurysms with Porous Metallic Stents AJNR Am. J. Neuroradiol., April 1, 2000; 21(4): 739 - 745. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. S. Hayward, R. P. Kelly, and P. Collins The roles of gender, the menopause and hormone replacement on cardiovascular function Cardiovasc Res, April 1, 2000; 46(1): 28 - 49. [Full Text] [PDF]
|
|
|
|
|
|
O. Iqbal, H. Messmore, D. Hoppensteadt, J. Fareed, and W. Wehrmacher State-of-the-Art Review : Thrombolytic Drugs in Acute Myocardial Infarction Clinical and Applied Thrombosis/Hemostasis, January 1, 2000; 6(1): 1 - 13. [PDF]
|
|
|
|
|
|
L. Kim, T. Lee, J. Fu, and M. E. Ritchie Characterization of MAP kinase and PKC isoform and effect of ACE inhibition in hypertrophy in vivo Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1808 - H1816. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Adachi, Y. Ohnishi, T. Shima, K. Yamashiro, A. Takei, N. Tamura, and M. Yokoyama Determinant of microvolt-level T-wave alternans in patients with dilated cardiomyopathy J. Am. Coll. Cardiol., August 1, 1999; 34(2): 374 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Mack, J. A. Magovern, T. A. Acuff, R. J. Landreneau, D. M. Tennison, E. J. Tinnerman, and J. A. Osborne Results of graft patency by immediate angiography in minimally invasive coronary artery surgery Ann. Thorac. Surg., August 1, 1999; 68(2): 383 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Johnson, W. E. Cohn, and C. A. Sirois Atrial fibrillation after minimally invasive coronary artery bypass J. Thorac. Cardiovasc. Surg., August 1, 1999; 118(2): 383 - 383. [Full Text]
|
|
|
|
|
|
P. H. Stone, D. S. Krantz, R. P. McMahon, A. D. Goldberg, L. C. Becker, B. R. Chaitman, H. A. Taylor, J. D. Cohen, K. E. Freedland, B. D. Bertolet, et al. Relationship among mental stress-induced ischemia and ischemia during daily life and during exercise: the Psychophysiologic Investigations of Myocardial Ischemia (PIMI) Study J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1476 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Tomaselli and E. Marban Electrophysiological remodeling in hypertrophy and heart failure Cardiovasc Res, May 1, 1999; 42(2): 270 - 283. [Full Text] [PDF]
|
|
|
|
|
|
M. N. Nanjee, J. E. Doran, P. G. Lerch, and N. E. Miller Acute Effects of Intravenous Infusion of ApoA1/Phosphatidylcholine Discs on Plasma Lipoproteins in Humans Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 979 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. X. Pan, J. Boal, for the Geriatrics Journal Club, E. Banks, V. Beral, P. J. L. Ong, M. B. Sorensen, C. S. Hayward, C. M. Webb, P. Collins, et al. Hormone Replacement Therapy for Secondary Prevention of Coronary Heart Disease JAMA, March 3, 1999; 281(9): 794 - 797. [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Li and G. Brooks Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system; potential targets for therapy? Eur. Heart J., March 2, 1999; 20(6): 406 - 420. [PDF]
|
|
|
|
|
|
P. J. Carek, M. Futrell, R. A. Gunn, L. Friedman, A. Koller, B. J. Maron, D. W. Glover, and G. O. Matheson Cardiovascular Screening of High School Athletes JAMA, February 17, 1999; 281(7): 607 - 608. [Full Text] [PDF]
|
|
|
|
|
|
D. S. Cannom and E. N. Prystowsky Management of Ventricular Arrhythmias: Detection, Drugs, and Devices JAMA, January 13, 1999; 281(2): 172 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Goldstein, R. D. Safian, D. Aliabadi, W. W. O'Neill, F. L. Shannon, J. Bassett, and M. Sakwa Intraoperative angiography to assess graft patency after minimally invasive coronary bypass Ann. Thorac. Surg., December 1, 1998; 66(6): 1978 - 1982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Josephson New Approaches to the Management of Atrial Fibrillation : The Role of the Atrial Defibrillator Circulation, October 20, 1998; 98(16): 1594 - 1596. [Full Text] [PDF]
|
|
|
|
|
|
N. R. Every, C. P. Cannon, C. Granger, D. J. Moliterno, F. V. Aguirre, J. D. Talley, J. Booth, S. Sapp, J. J. Ferguson, and for the GUARANTEE investigators Influence of insurance type on the use of procedures, medications and hospital outcome in patients with unstable angina: results from the GUARANTEE registry J. Am. Coll. Cardiol., August 1, 1998; 32(2): 387 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Sparks, S. Jayaprakash, J. K. Vohra, H. G. Mond, A. G. Yapanis, L. E. Grigg, and J. M. Kalman Left atrial "stunning" following radiofrequency catheter ablation of chronic atrial flutter J. Am. Coll. Cardiol., August 1, 1998; 32(2): 468 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.J.G.L de Smet, J van der Zande, Y.J.M van der Helm, R.E Kuntz, C Borst, and M.J Post The atherosclerotic Yucatan animal model to study the arterial response after balloon angioplasty: the natural history of remodeling Cardiovasc Res, July 1, 1998; 39(1): 224 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Oberhoff, S. Novak, C. Herdeg, A. Baumbach, A. Kranzhofer, A. Bohnet, B. Horch, H. Hanke, K. K. Haase, and K. R. Karsch Local and systemic delivery of low molecular weight heparin stimulates the reendothelialization after balloon angioplasty Cardiovasc Res, June 1, 1998; 38(3): 751 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shinoka, D. Shum-Tim, P. X. Ma, R. E. Tanel, N. Isogai, R. Langer, J. P. Vacanti, and J. E. Mayer Jr. Creation Of Viable Pulmonary Artery Autografts Through Tissue Engineering J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 536 - 546. [Abstract] [Full Text]
|
|
|
|
|
|
A. D Wickenden, R. Kaprielian, Z. Kassiri, J. N Tsoporis, R. Tsushima, G. I Fishman, and P. H Backx The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure Cardiovasc Res, February 1, 1998; 37(2): 312 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Schwarz, J. Fleischhauer, H. Montino, R. Chakupurakal, M. Foresti, T. Schuetz, S. Sack, M. Mohri, M. Arras, W. Schaper, et al. Infarct Size Reduction by Ischemic Preconditioning is a Monophasic, Short-Lived Phenomenon in Anesthetized Pigs Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(1): 63 - 70. [Abstract] [PDF]
|
|
|
|
|
|
T. Z. Naqvi, P. K. Shah, P. A. Ivey, M. D. Molloy, P. Linn, M. Linker-Israeli, B. Cercek, and S. Kaul Therapeutic Concentrations of Heparin Augment Platelet Activation at the Time of Coronary Angiography Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(2): 91 - 101. [Abstract] [PDF]
|
|
|
|
|
|
R. H. Dave, S. L. Hale, and R. A. Kloner The Effect of Melatonin on Hemodynamics, Blood Flow, and Myocardial Infarct Size in a Rabbit Model of Ischemia-Reperfusion Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1998; 3(2): 153 - 159. [Abstract] [PDF]
|
|
|
|
|
|
W. E. Cohn, H. C. Suen, R. M. Weintraub, and R. G. Johnson The "H" graft: An alternative approach for performing minimally invasive direct coronary artery bypass J. Thorac. Cardiovasc. Surg., January 1, 1998; 115(1): 148 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Wier, H. E. D. J. t. Keurs, E. Marban, W. D. Gao, and C. W. Balke Ca2+ `Sparks' and Waves in Intact Ventricular Muscle Resolved by Confocal Imaging Circ. Res., October 19, 1997; 81(4): 462 - 469. [Abstract] [Full Text]
|
|
|
|
|
|
G. Melillo, M. Scoccianti, I. Kovesdi, J. Safi Jr, T. Riccioni, and M. C Capogrossi Gene therapy for collateral vessel development Cardiovasc Res, September 1, 1997; 35(3): 480 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. D. McCann, L. S. Seiden, L. J. Rubin, and G. A. Ricaurte Brain Serotonin Neurotoxicity and Primary Pulmonary Hypertension From Fenfluramine and Dexfenfluramine: A Systematic Review of the Evidence JAMA, August 27, 1997; 278(8): 666 - 672. [Abstract] [PDF]
|
|
|
|
|
|
N. F. Col, S. G. Pauker, M. H. Eckman, and J. B. Wong Facilitating Patient-Specific Decisions Regarding Hormone Replacement Therapy-Reply JAMA, August 13, 1997; 278(6): 476 - 476. [Abstract] [PDF]
|
|
|
|
|
|
T. A. Pearson and M. Myerson Treatment of Hypercholesterolemia in Women: Equality, Effectiveness, and Extrapolation of Evidence JAMA, April 23, 1997; 277(16): 1320 - 1321. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Prueksaritanont, L. M. Gorham, J. A. Naue, T. G. Hamill, B. C. Askew, and K. P. Vyas Disposition of L-738,167, A Potent and Long-Acting Fibrinogen Receptor Antagonist, in Dogs. Dose-Dependent Pharmacokinetics Drug Metab. Dispos., March 1, 1997; 25(3): 355 - 361. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. J. Ackermann Anticoagulant Therapy in Patients Aged 80 Years or More With Atrial Fibrillation: More Caution Is Needed Arch Fam Med, March 1, 1997; 6(2): 105 - 110. [Abstract] [PDF]
|
|
|
|
|
|
E. M. Ohman and B. E. Tardiff Periprocedural Cardiac Marker Elevation After Percutaneous Coronary Artery Revascularization: Importance and Implications JAMA, February 12, 1997; 277(6): 495 - 497. [Abstract] [PDF]
|
|
|
|
|
|
S. Kaul, T. Z. Naqvi, M. C. Fishbein, B. Cercek, J. J. Badimon, T. C. Hutsell, S. Thomas, M. Molloy, and P. K. Shah Local Delivery of an Ultra-short-acting Nitric Oxide- releasing Compound, DMHD/NO, Is Highly Effective in Inhibiting Acute Platelet-Thrombus Formation on Injured Arterial Strips Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 1997; 2(3): 181 - 193. [Abstract] [PDF]
|
|