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(Circulation. 1995;92:1947-1953.)
© 1995 American Heart Association, Inc.

Articles

Trandolapril Decreases Prevalence of Ventricular Ectopic Activity in Middle-Aged SHR

B. Chevalier, PhD; D. Heudes, MD; C. Heymes; A. Basset; T. Dakhli; Y. Bansard, PhD; S. Jouquey, PhD; G. Hamon, PhD; P. Bruneval, MD; B. Swynghedauw, MD, PhD; F. Carré, MD, PhD

From INSERM-U127, Hôpital Lariboisière (B.C., B.S.), Paris, France; INSERM-U28, Hôpital Broussais (D.H., A.B., T.D., P.B.), Paris, France; Département de Santé Publique, Faculté de Médecine (Y.B.), Rennes, France; Laboratoire Roussel-UCLAF (S.J., G.H.), Romainville, France; and Département de Physiologie, Faculté de Médecine (F.C.), Rennes, France.

Correspondence to Dr Brigitte Chevalier, INSERM-U127, Hôpital Lariboisière, 41 Bd de la Chapelle, 75010 Paris, France.

Background Although severe arrhythmias are still a major problem in patients with left ventricular hypertrophy (LVH), the relationship between ventricular remodeling and its regression or prevention, and the prevalence of ventricular premature beats (VPB) or more sustained arrhythmias are still poorly explored in hypertensive heart disease.

Methods and Results Holter monitoring was used to quantify supraventricular premature beats and VPB and heart rate (HR) in middle-aged spontaneously hypertensive rats (SHR) and Wistar rats treated for 3 months with trandolapril (ACE inhibitor, 0.3 mg/kg per day). Hypertrophy and fibrosis were morphometrically determined. Statistical analysis was performed with the use of simple regression and multivariate data analysis (cluster and correspondence analysis). SHR have higher cardiac mass and fibrosis, more VPB, and a decreased HR. Cluster analysis demonstrated that trandolapril was only effective in SHR. Trandolapril significantly reduced cardiac hypertrophy, fibrosis, and VPB incidence and increased the HR. Simple regression analysis showed that VPB incidence correlated to both hypertrophy and fibrosis. Correspondence analysis evidenced a strong correlation between hypertrophy, fibrosis, and VPB, but only for severe hypertrophy, and the correlation disappeared for moderate hypertrophy.

Conclusions After trandolapril treatment, the regression of VPB incidence not only is linked to hypertrophy and fibrosis, but additional causal factors also are involved including the myocardial phenotype and new calcium metabolism. Our model of Holter monitoring in conscious middle-aged SHR and multivariate data analysis might be useful in correlating myocardial structural modifications and ectopic activity.

Key Words: arrhythmia • hypertrophy

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