(Circulation. 1995;92:1169-1178.)
© 1995 American Heart Association, Inc.
Articles |
Alterations in Intracellular Calcium Handling Associated With the Inverse Force-Frequency Relation in Human Dilated Cardiomyopathy
From the Medizinische Klinik III (B.P., B.K., M.M., C.H., H.J., G.H.) and Physiologisches Institut (J.W.), Universität Freiburg, and Klinik für Thorax- und Kardiovaskularchirurgie (H.P., K.M.), Herzzentrum Nordrhein-Westfalen, Bad Oeynhausen, Germany.
Correspondence to Burkert Pieske, MD, Medizinische Klinik III, Universität Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany.
Background The present study was performed to test the hypothesis that the altered force-frequency relation in human failing dilated cardiomyopathy may be attributed to alterations in intracellular calcium handling.
Methods and Results The force-frequency relation was investigated in isometrically contracting ventricular muscle strip preparations from 5 nonfailing human hearts and 7 hearts with end-stage failing dilated cardiomyopathy. Intracellular calcium cycling was measured simultaneously by use of the bioluminescent photoprotein aequorin. Stimulation frequency was increased stepwise from 15 to 180 beats per minute (37°C). In nonfailing myocardium, twitch tension and aequorin light emission rose with increasing rates of stimulation. Maximum average twitch tension was reached at 150 min-1 and was increased to 212±34% (P<.05) of the value at 15 min-1. Aequorin light emission was lowest at 15 min-1 and was maximally increased at 180 min-1 to 218±39% (P<.01). In the failing myocardium, average isometric tension was maximum at 60 min-1 (106±7% of the basal value at 15 min-1, P=NS) and then decreased continuously to 62±9% of the basal value at 180 min-1 (P<.002). In the failing myocardium, aequorin light emission was highest at 15 min-1. At 180 min-1, it was decreased to 71±7% of the basal value (P<.01). Including both failing and nonfailing myocardium, there was a close correlation between the frequencies at which aequorin light emission and isometric tension were maximum (r=.92; n=19; P<.001). Action potential duration decreased similarly with increasing stimulation frequencies in nonfailing and end-stage failing myocardium. Sarcoplasmic reticulum 45Ca2+ uptake, measured in homogenates from the same hearts, was significantly reduced in failing myocardium (3.60±0.51 versus 1.94±0.18 (nmol/L) · min-1 · mg protein-1, P<.005).
Conclusions These data indicate that the altered force-frequency relation of the failing human myocardium results from disturbed excitation-contraction coupling with decreased calcium cycling at higher rates of stimulation.
Key Words: aequorin • excitation • contraction • sarcoplasmic reticulum • heart failure
This article has been cited by other articles:
 |
|
 |
|
  M. N. Sharikabad, J. M. Aronsen, E. Haugen, J. Pedersen, A.-S. W. Moller, H. K. Mork, H. C. D. Aass, O. M. Sejersted, I. Sjaastad, and O. Brors Cardiomyocytes from postinfarction failing rat hearts have improved ischemia tolerance Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H787 - H795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ikeda, M. Hoshijima, and K. R. Chien Toward Biologically Targeted Therapy of Calcium Cycling Defects in Heart Failure Physiology, February 1, 2008; 23(1): 6 - 16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bisping, G. Tenderich, P. Barckhausen, B. Stumme, S. Bruns, D. von Lewinski, and B. Pieske Atrial myocardium is the predominant inotropic target of adrenomedullin in the human heart Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3001 - H3007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Lamberts, N. Hamdani, T. W. Soekhoe, N. M. Boontje, R. Zaremba, L. A. Walker, P. P. de Tombe, J. van der Velden, and G. J. M. Stienen Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium J. Physiol., July 15, 2007; 582(2): 695 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hiranandani, S. Raman, A. Kalyanasundaram, M. Periasamy, and P. M. L. Janssen Frequency-dependent contractile strength in mice over- and underexpressing the sarco(endo)plasmic reticulum calcium-ATPase Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R30 - R36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Varian and P. M. L. Janssen Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2212 - H2219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Givertz, C. Andreou, C. H. Conrad, and W. S. Colucci Direct Myocardial Effects of Levosimendan in Humans With Left Ventricular Dysfunction: Alteration of Force-Frequency and Relaxation-Frequency Relationships Circulation, March 13, 2007; 115(10): 1218 - 1224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Leszek, J. Korewicki, A. Klisiewicz, J. Janas, A. Biederman, A. Browarek, D. Charlemagne, and P. Trouve Reduced myocardial expression of calcium handling protein in patients with severe chronic mitral regurgitation Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 737 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vollmann, L. Luthje, P. Schott, G. Hasenfuss, and C. Unterberg-Buchwald Biventricular Pacing Improves the Blunted Force-Frequency Relation Present During Univentricular Pacing in Patients With Heart Failure and Conduction Delay Circulation, February 21, 2006; 113(7): 953 - 959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. H. T. Wehrens, S. E. Lehnart, S. Reiken, J. A. Vest, A. Wronska, and A. R. Marks Inaugural Article: Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression PNAS, January 17, 2006; 103(3): 511 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B M Mayosi, A Kardos, C H Davies, F Gumedze, A Hovnanian, S Burge, and H Watkins Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure Heart, January 1, 2006; 92(1): 105 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Luers, F. Fialka, A. Elgner, D. Zhu, J. Kockskamper, D. von Lewinski, and B. Pieske Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium-a mechanism for the slow force response Cardiovasc Res, December 1, 2005; 68(3): 454 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Sipido and D. Eisner Something old, something new: Changing views on the cellular mechanisms of heart failure Cardiovasc Res, November 1, 2005; 68(2): 167 - 174. [Full Text] [PDF]
|
|
|
|
|
|
M M H Cheung, J F Smallhorn, B W McCrindle, G S Van Arsdell, and A N Redington Non-invasive assessment of ventricular force-frequency relations in the univentricular circulation by tissue Doppler echocardiography: a novel method of assessing myocardial performance in congenital heart disease Heart, October 1, 2005; 91(10): 1338 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Balasubramaniam, S. Chawla, A. A. Grace, and C. L.-H. Huang Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca2+ homeostasis Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1584 - H1593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Maier, C. Wahl-Schott, W. Horn, S. Weichert, C. Pagel, S. Wagner, N. Dybkova, O. J. Muller, M. Nabauer, W.-M. Franz, et al. Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats Cardiovasc Res, September 1, 2005; 67(4): 636 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Edes, Z. Gasior, and K. Wita Effects of nebivolol on left ventricular function in elderly patients with chronic heart failure: results of the ENECA study Eur J Heart Fail, June 1, 2005; 7(4): 631 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Harris, G. D. Mills, X. Chen, H. Kubo, R. M. Berretta, V. S. Votaw, L. F. Santana, and S. R. Houser Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca2+ Release Circ. Res., March 18, 2005; 96(5): 543 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Loughrey, G. L. Smith, and K. E. MacEachern Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1149 - H1159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Chaudhary, E. I. Rossman, V. Piacentino III, A. Kenessey, C. Weber, J. P. Gaughan, K. Ojamaa, I. Klein, D. M. Bers, S. R. Houser, et al. Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart J. Am. Coll. Cardiol., August 18, 2004; 44(4): 837 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Hobai, C. Maack, and B. O'Rourke Partial Inhibition of Sodium/Calcium Exchange Restores Cellular Calcium Handling in Canine Heart Failure Circ. Res., August 6, 2004; 95(3): 292 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.E Diaz, H.K Graham, and A.W Trafford Enhanced sarcolemmal Ca2+ efflux reduces sarcoplasmic reticulum Ca2+ content and systolic Ca2+ in cardiac hypertrophy Cardiovasc Res, June 1, 2004; 62(3): 538 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. J. Schultz, B. J. Glascock, S. A. Witt, M. L. Nieman, K. J. Nattamai, L. H. Liu, J. N. Lorenz, G. E. Shull, T. R. Kimball, and M. Periasamy Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1146 - H1153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Jortani, S. D. Prabhu, and R. Valdes Jr Strategies for Developing Biomarkers of Heart Failure Clin. Chem., February 1, 2004; 50(2): 265 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Huke, L. H Liu, D. Biniakiewicz, W. T Abraham, and M. Periasamy Altered force-frequency response in non-failing hearts with decreased SERCA pump-level Cardiovasc Res, September 1, 2003; 59(3): 668 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Baartscheer, C. A. Schumacher, C. N.W. Belterman, R. Coronel, and J. W.T. Fiolet SR calcium handling and calcium after-transients in a rabbit model of heart failure Cardiovasc Res, April 1, 2003; 58(1): 99 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vogel, M. M.H. Cheung, J. Li, S. B. Kristiansen, M. R. Schmidt, P. A. White, K. Sorensen, and A. N. Redington Noninvasive Assessment of Left Ventricular Force-Frequency Relationships Using Tissue Doppler-Derived Isovolumic Acceleration: Validation in an Animal Model Circulation, April 1, 2003; 107(12): 1647 - 1652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pieske and S. R Houser [Na+]i handling in the failing human heart Cardiovasc Res, March 15, 2003; 57(4): 874 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Schillinger, J. W Fiolet, K. Schlotthauer, and G. Hasenfuss Relevance of Na+-Ca2+ exchange in heart failure Cardiovasc Res, March 15, 2003; 57(4): 921 - 933. [Full Text] [PDF]
|
|
|
|
|
|
H. E Cingolani, N. G Perez, B. Pieske, D. von Lewinski, and M. C Camilion de Hurtado Stretch-elicited Na+/H+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart Cardiovasc Res, March 15, 2003; 57(4): 953 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Ward, A. J Pope, D. S Loiselle, and M. B Cannell Reduced contraction strength with increased intracellular [Ca2+] in left ventricular trabeculae from failing rat hearts J. Physiol., January 15, 2003; 546(2): 537 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Schillinger and H. Kogler Altered phosphorylation and Ca2+-sensitivity of myofilaments in human heart failure Cardiovasc Res, January 1, 2003; 57(1): 5 - 7. [Full Text] [PDF]
|
|
|
|
|
|
M. Petretta, M. L.E. Vicario, L. Spinelli, A. Ferro, A. Cuocolo, M. Condorelli, and D. Bonaduce Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy Eur J Heart Fail, December 1, 2002; 4(6): 727 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nemoto, G. DeFreitas, D. L. Mann, and B. A. Carabello Effects of changes in left ventricular contractility on indexes of contractility in mice Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2504 - H2510. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pieske and J. Kockskamper Alternans Goes Subcellular: A "Disease" of the Ryanodine Receptor? Circ. Res., October 4, 2002; 91(7): 553 - 555. [Full Text] [PDF]
|
|
|
|
|
|
M.E. Diaz, D.A. Eisner, and S.C. O'Neill Depressed Ryanodine Receptor Activity Increases Variability and Duration of the Systolic Ca2+ Transient in Rat Ventricular Myocytes Circ. Res., October 4, 2002; 91(7): 585 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kindermann, B. Schwaab, N. Finkler, S. Schaller, M. Bohm, and G. Frohlig Defining the optimum upper heart rate limit during exercise. A study in pacemaker patients with heart failure Eur. Heart J., August 2, 2002; 23(16): 1301 - 1308. [Abstract] [PDF]
|
|
|
|
|
|
B. Pieske, L. S. Maier, V. Piacentino III, J. Weisser, G. Hasenfuss, and S. Houser Rate Dependence of [Na+]i and Contractility in Nonfailing and Failing Human Myocardium Circulation, July 23, 2002; 106(4): 447 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Alpert, L. A. Mulieri, and D. Warshaw The failing human heart Cardiovasc Res, April 1, 2002; 54(1): 1 - 10. [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss, L. S. Maier, H.-P. Hermann, C. LUers, M. HUnlich, O. Zeitz, P. M.L. Janssen, and B. Pieske Influence of Pyruvate on Contractile Performance and Ca2+ Cycling in Isolated Failing Human Myocardium Circulation, January 15, 2002; 105(2): 194 - 199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Somura, H. Izawa, M. Iwase, Y. Takeichi, R. Ishiki, T. Nishizawa, A. Noda, K. Nagata, Y. Yamada, and M. Yokota Reduced Myocardial Sarcoplasmic Reticulum Ca2+-ATPase mRNA Expression and Biphasic Force-Frequency Relations in Patients With Hypertrophic Cardiomyopathy Circulation, August 7, 2001; 104(6): 658 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Forini, A. Paolicchi, T. Pizzorusso, G. M. Ratto, M. Saviozzi, V. Vanini, and G. Iervasi 3,5,3'-Triiodothyronine deprivation affects phenotype and intracellular [Ca2+]i of human cardiomyocytes in culture Cardiovasc Res, August 1, 2001; 51(2): 322 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Baker, C. H. Redfern, M. D. Harwood, P. C. Simpson, and B. R. Conklin Abnormal contraction caused by expression of Gi-coupled receptor in transgenic model of dilated cardiomyopathy Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1653 - H1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Periasamy Adenoviral-Mediated SERCA Gene Transfer Into Cardiac Myocytes : How Much Is Too Much? Circ. Res., March 2, 2001; 88(4): 373 - 375. [Full Text] [PDF]
|
|
|
|
|
|
S. R Houser Reduced abundance of transverse tubules and L-type calcium channels: another cause of defective contractility in failing ventricular myocytes Cardiovasc Res, February 1, 2001; 49(2): 253 - 256. [Full Text] [PDF]
|
|
|
|
|
|
S. E. Litwin, D. Zhang, and J. H. B. Bridge Dyssynchronous Ca2+ Sparks in Myocytes From Infarcted Hearts Circ. Res., November 24, 2000; 87(11): 1040 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Sipido, P. G. A. Volders, S. H. M. de Groot, F. Verdonck, F. Van de Werf, H. J. J. Wellens, and M. A. Vos Enhanced Ca2+ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes : Potential Link Between Contractile Adaptation and Arrhythmogenesis Circulation, October 24, 2000; 102(17): 2137 - 2144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Sjaastad, O. M. Sejersted, A. Ilebekk, and R. Bjornerheim Echocardiographic criteria for detection of postinfarction congestive heart failure in rats J Appl Physiol, October 1, 2000; 89(4): 1445 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ito, X. Yan, M. Tajima, Z. Su, W. H. Barry, and B. H. Lorell Contractile Reserve and Intracellular Calcium Regulation in Mouse Myocytes From Normal and Hypertrophied Failing Hearts Circ. Res., September 29, 2000; 87(7): 588 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Maier, P. Barckhausen, J. Weisser, I. Aleksic, M. Baryalei, and B. Pieske Ca2+ handling in isolated human atrial myocardium Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H952 - H958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sen, G. Cui, G. C. Fonarow, and H. Laks Differences in mechanisms of SR dysfunction in ischemic vs. idiopathic dilated cardiomyopathy Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H709 - H718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Barrere-Lemaire, C. Piot, F. Leclercq, J. Nargeot, and S. Richard Facilitation of L-type calcium currents by diastolic depolarization in cardiac cells: impairment in heart failure Cardiovasc Res, August 1, 2000; 47(2): 336 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Hajjar, R. H.G. Schwinger, U. Schmidt, C. S. Kim, D. Lebeche, A. A. Doye, and J. K. Gwathmey Myofilament Calcium Regulation in Human Myocardium Circulation, April 11, 2000; 101(14): 1679 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z Kassiri, R Myers, R Kaprielian, H S Banijamali, and P H Backx Rate-dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system J. Physiol., April 1, 2000; 524(1): 221 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S Maier, C. Schwan, W. Schillinger, K. Minami, U. Schutt, and B. Pieske Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium Cardiovasc Res, March 1, 2000; 45(4): 913 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U Ravens and D Dobrev Regulation of sarcoplasmic reticulum Ca2+-ATPase and phospholamban in the failing and nonfailing heart Cardiovasc Res, January 1, 2000; 45(1): 245 - 252. [Full Text] [PDF]
|
|
|
|
|
|
W. V. Houck, L. C. Pan, S. B. Kribbs, M. J. Clair, G. M. McDaniel, R. S. Krombach, W. M. Merritt, C. Pirie, J. P. Iannini, R. Mukherjee, et al. Effects of Growth Hormone Supplementation on Left Ventricular Morphology and Myocyte Function With the Development of Congestive Heart Failure Circulation, November 9, 1999; 100(19): 2003 - 2009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Bartling, H. Milting, H. Schumann, D. Darmer, L. Arusoglu, M. M. Koerner, A. El-Banayosy, R. Koerfer, J. Holtz, and H.-R. Zerkowski Myocardial Gene Expression of Regulators of Myocyte Apoptosis and Myocyte Calcium Homeostasis During Hemodynamic Unloading by Ventricular Assist Devices in Patients With End-Stage Heart Failure Circulation, November 9, 1999; 100 (2009): II-216 - II-223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Krieg, T. Wahlers, W. Giess, R. Rohde, M. Hartrumpf, M. Bund, and A. Haverich Inhaled nitric oxide and inhaled prostaglandin E1: effect on left ventricular contractility when used for treatment of experimental pulmonary hypertension Eur. J. Cardiothorac. Surg., November 1, 1999; 14(5): 494 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Fallavollita, S. Jacob, R. F. Young, and J. M. Canty Jr. Regional alterations in SR Ca2+-ATPase, phospholamban, and HSP-70 expression in chronic hibernating myocardium Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1418 - H1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Kim, W. H. Devlin, S. K. Das, J. Petrusha, D. Montgomery, and M. R. Starling Effects of {beta}-Adrenergic Blocking Therapy on Left Ventricular Diastolic Relaxation Properties in Patients With Dilated Cardiomyopathy Circulation, August 17, 1999; 100(7): 729 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Prestle, S. Dieterich, M. Preuss, U. Bieligk, and G. Hasenfuss Heterogeneous transmural gene expression of calcium-handling proteins and natriuretic peptides in the failing human heart Cardiovasc Res, August 1, 1999; 43(2): 323 - 331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Flesch, C. Maack, B. Cremers, A. T. Baumer, M. Sudkamp, and M. Bohm Effect of {beta}-Blockers on Free Radical–Induced Cardiac Contractile Dysfunction Circulation, July 27, 1999; 100(4): 346 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Pieske, L. S. Maier, D. M. Bers, and G. Hasenfuss Ca2+ Handling and Sarcoplasmic Reticulum Ca2+ Content in Isolated Failing and Nonfailing Human Myocardium Circ. Res., July 9, 1999; 85(1): 38 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Meissner, J.-Y. Min, N. Haake, S. Hirt, and R. Simon Dantrolene sodium improves the force-frequency relationship and {beta}-adrenergic responsiveness in failing human myocardium Eur J Heart Fail, June 1, 1999; 1(2): 177 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Murakami, J. Zhang, M. H. J. Eijgelshoven, W. Chen, W. C. Carlyle, Y. Zhang, G. Gong, and R. J. Bache Myocardial creatine kinase kinetics in hearts with postinfarction left ventricular remodeling Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H892 - H900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Houser and E. G. Lakatta Function of the Cardiac Myocyte in the Conundrum of End-Stage, Dilated Human Heart Failure Circulation, February 9, 1999; 99(5): 600 - 604. [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss, W. Schillinger, S. E. Lehnart, M. Preuss, B. Pieske, L. S. Maier, J. Prestle, K. Minami, and H. Just Relationship Between Na+-Ca2+–Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium Circulation, February 9, 1999; 99(5): 641 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Anger, A.-M. Lompre, O. Vallot, F. Marotte, L. Rappaport, and J.-L. S. MD Cellular Distribution of Ca2+ Pumps and Ca2+ Release Channels in Rat Cardiac Hypertrophy Induced by Aortic Stenosis Circulation, December 1, 1998; 98(22): 2477 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Prabhu Ryanodine and the left ventricular force-interval and relaxation-interval relations in closed-chest dogs: insights on calcium handling Cardiovasc Res, December 1, 1998; 40(3): 483 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss, B. Pieske, M. Castell, B. Kretschmann, L. S. Maier, and H. Just Influence of the Novel Inotropic Agent Levosimendan on Isometric Tension and Calcium Cycling in Failing Human Myocardium Circulation, November 17, 1998; 98(20): 2141 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss Calcium Pump Overexpression and Myocardial Function : Implications for Gene Therapy of Myocardial Failure Circ. Res., November 2, 1998; 83(9): 966 - 968. [Full Text] [PDF]
|
|
|
|
|
|
C Mittmann, T Eschenhagen, and H Scholz Cellular and molecular aspects of contractile dysfunction in heart failure Cardiovasc Res, August 1, 1998; 39(2): 267 - 275. [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss Animal models of human cardiovascular disease, heart failure and hypertrophy Cardiovasc Res, July 1, 1998; 39(1): 60 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dipla, J. A. Mattiello, V. Jeevanandam, S. R. Houser, and K. B. Margulies Myocyte Recovery After Mechanical Circulatory Support in Humans With End-Stage Heart Failure Circulation, June 16, 1998; 97(23): 2316 - 2322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. C. Dekker, H. Rademaker, J. T. Vermeulen, T. Opthof, R. Coronel, J. A. E. Spaan, and M. J. Janse Cellular Uncoupling During Ischemia in Hypertrophied and Failing Rabbit Ventricular Myocardium : Effects of Preconditioning Circulation, May 5, 1998; 97(17): 1724 - 1730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Maier, R. Brandes, B. Pieske, and D. M. Bers Effects of left ventricular hypertrophy on force and Ca2+ handling in isolated rat myocardium Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1361 - H1370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss Alterations of calcium-regulatory proteins in heart failure Cardiovasc Res, February 1, 1998; 37(2): 279 - 289. [Full Text] [PDF]
|
|
|
|
|
|
C.W. Balke and S. R. Shorofsky Alterations in calcium handling in cardiac hypertrophy and heart failure Cardiovasc Res, February 1, 1998; 37(2): 290 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Richard, F. Leclercq, S. Lemaire, C. Piot, and J. Nargeot Ca2+ currents in compensated hypertrophy and heart failure Cardiovasc Res, February 1, 1998; 37(2): 300 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D Wickenden, R. Kaprielian, Z. Kassiri, J. N Tsoporis, R. Tsushima, G. I Fishman, and P. H Backx The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure Cardiovasc Res, February 1, 1998; 37(2): 312 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M Phillips, P. Narayan, A. M Gomez, K. Dilly, L. R Jones, W.J. Lederer, and R. A Altschuld Sarcoplasmic reticulum in heart failure: central player or bystander? Cardiovasc Res, February 1, 1998; 37(2): 346 - 351. [Full Text] [PDF]
|
|
|
|
|
|
M. A Movsesian and R. H.G Schwinger Calcium sequestration by the sarcoplasmic reticulum in heart failure Cardiovasc Res, February 1, 1998; 37(2): 352 - 359. [Full Text] [PDF]
|
|
|
|
|
|
M. Meyer and W. H Dillmann Sarcoplasmic reticulum Ca2+-ATPase overexpression by adenovirus mediated gene transfer and in transgenic mice Cardiovasc Res, February 1, 1998; 37(2): 360 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P de Tombe Altered contractile function in heart failure Cardiovasc Res, February 1, 1998; 37(2): 367 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Schaub, M. A. Hefti, R. A. Zuellig, and I. Morano Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms Cardiovasc Res, February 1, 1998; 37(2): 381 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Neumann, U. Ravens, and G. Heusch Characterization of excitation-contraction coupling in conscious dogs with pacing-induced heart failure Cardiovasc Res, February 1, 1998; 37(2): 456 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R Sipido, T. Stankovicova, W. Flameng, J. Vanhaecke, and F. Verdonck Frequency dependence of Ca2+ release from the sarcoplasmic reticulum in human ventricular myocytes from end-stage heart failure Cardiovasc Res, February 1, 1998; 37(2): 478 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Holubarsch, J Ludemann, S Wiessner, T. Ruf, H Schulte-Baukloh, S Schmidt-Schweda, B Pieske, H Posival, and H Just Shortening versus isometric contractions in isolated human failing and non-failing left ventricular myocardium: dependency of external work and force on muscle length, heart rate and inotropic stimulation Cardiovasc Res, January 1, 1998; 37(1): 46 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pauschinger, A. Doerner, A. Remppis, R. Tannhauser, U. Kuhl, and H.-P. Schultheiss Differential myocardial abundance of collagen type I and type III mRNA in dilated cardiomyopathy: effects of myocardial inflammation Cardiovasc Res, January 1, 1998; 37(1): 123 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Spinale, R. Mukherjee, J. P. Iannini, S. Whitebread, L. Hebbar, M. J. Clair, D. M. Melton, M. H. Cox, P. B. Thomas, and P. B. Marc de Gasparo Modulation of the Renin-Angiotensin Pathway Through Enzyme Inhibition and Specific Receptor Blockade in Pacing-Induced Heart Failure : II. Effects on Myocyte Contractile Processes Circulation, October 7, 1997; 96(7): 2397 - 2406. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. H. G. Schwinger, K. Brixius, U. Bavendiek, S. Hoischen, J. Müller-Ehmsen, B. Bölck, and E. Erdmann Effect of Cyclopiazonic Acid on the Force-Frequency Relationship in Human Nonfailing Myocardium J. Pharmacol. Exp. Ther., October 1, 1997; 283(1): 286 - 292. [Abstract] [Full Text]
|
|
|
|
|
|
K. Brixius, M. Pietsch, S. Hoischen, J. Muller-Ehmsen, and R. H. G. Schwinger Effect of inotropic interventions on contraction and Ca2+ transients in the human heart J Appl Physiol, August 1, 1997; 83(2): 652 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Davia, C.H Davies, and S.E Harding Effects of inhibition of sarcoplasmic reticulum calcium uptake on contraction in myocytes isolated from failing human ventricle Cardiovasc Res, January 1, 1997; 33(1): 88 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hasenfuss, L. A. Mulieri, P. D. Allen, H. Just, and N.R. Alpert Influence of Isoproterenol and Ouabain on Excitation-Contraction Coupling, Cross-Bridge Function, and Energetics in Failing Human Myocardium Circulation, December 15, 1996; 94(12): 3155 - 3160. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Pogwizd, K. Schlotthauer, L. Li, W. Yuan, and D. M. Bers Arrhythmogenesis and Contractile Dysfunction in Heart Failure : Roles of Sodium-Calcium Exchange, Inward Rectifier Potassium Current, and Residual {beta}-Adrenergic Responsiveness Circ. Res., June 8, 2001; 88(11): 1159 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vogel, M. R. Schmidt, S. B. Kristiansen, M. Cheung, P. A. White, K. Sorensen, and A. N. Redington Validation of Myocardial Acceleration During Isovolumic Contraction as a Novel Noninvasive Index of Right Ventricular Contractility: Comparison With Ventricular Pressure-Volume Relations in an Animal Model Circulation, April 9, 2002; 105(14): 1693 - 1699. [Abstract] [Full Text] [PDF]
|
|