(Circulation. 1995;92:296-299.)
© 1995 American Heart Association, Inc.
Articles |
Relation Between the Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Late Luminal Narrowing After Coronary Angioplasty
From University and CHRU de Lille (M.H., C.B., E.P.M., J.-M.L., M.E.B., P.A.) and Institut Pasteur de Lille (C.A., N.H., P.A.), Lille, France.
Correspondence to Michel Bertrand, MD, Service de Cardiologie B, Hôpital Cardiologique, Boulevard du Professeur J Leclercq, 59037 Lille, France.
Background The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been implicated in the pathogenesis of coronary artery disease. The deletion allele is strongly associated with the level of circulating ACE and is a potent risk factor for myocardial infarction. Recently, the deletion allele was also associated with the occurrence of visually diagnosed restenosis after percutaneous transluminal coronary angioplasty (PTCA) in a selected population of patients with acute myocardial infarction.
Methods and Results We investigated the influence of the ACE I/D polymorphism on the occurrence of restenosis after PTCA with the use of quantitative coronary angiography. ACE I/D genotypes were characterized in 118 consecutive patients who had one-vessel disease and were undergoing systematic angiographic follow-up. Coronary angiograms were analyzed before and after PTCA and at follow-up (7.4±3.0 months). Before PTCA, there were no clinical or angiographic differences among the three groups of genotypes (DD, n=39; ID, n=62; II, n=17). After PTCA, the mean differences in minimal luminal diameter between post-PTCA and pre-PTCA angiograms (acute gain) were identical in the three groups, as was the mean percent residual stenosis. At follow-up angiography, the mean difference in minimal coronary luminal diameter between post-PTCA and follow-up angiograms (late loss) was not significantly different in the three groups of genotypes. The percentage of patients with restenosis defined as a >50% stenosis was identical in the three groups.
Conclusions In this quantitative study, the I/D polymorphism of the ACE gene had no influence on the occurrence of restenosis after coronary angioplasty.
Key Words: angiotensin • enzymes • genes • angioplasty • stenosis
This article has been cited by other articles:
 |
|
 |
|
  M Hamon, S Fradin, A Denizet, E Filippi-Codaccioni, G Grollier, and R Morello Prospective evaluation of the effect of an angiotensin I converting enzyme gene polymorphism on the long term risk of major adverse cardiac events after percutaneous coronary intervention Heart, March 1, 2003; 89(3): 321 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Humphries, C. Bauters, A. Meirhaeghe, L. Luong, M. Bertrand, and P. Amouyel The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis Eur. Heart J., May 1, 2002; 23(9): 721 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. R. P. Agema, J. W. Jukema, S. N. Pimstone, and J. J. P. Kastelein Genetic aspects of restenosis after percutaneous coronary interventions;towards more tailored therapy Eur. Heart J., November 2, 2001; 22(22): 2058 - 2074. [PDF]
|
|
|
|
 |
|
 J. C. Rodriguez-Perez, F. Rodriguez-Esparragon, O. Hernandez-Perera, A. Anabitarte, A. Losada, A. Medina, E. Hernandez, D. Fiuza, O. Avalos, C. Yunis, et al. Association of angiotensinogen m235t and a(-6)g gene polymorphisms with coronary heart disease with independence of essential hypertension: the procagene study J. Am. Coll. Cardiol., May 1, 2001; 37(6): 1536 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Y. L. Zee, A. Fernandez-Ortiz, C. Macaya, E. Pintor, K. Lindpaintner, and A. Fernandez-Cruz ACE D/I Polymorphism and Incidence of Post-PTCA Restenosis : A Prospective, Angiography-Based Evaluation Hypertension, March 1, 2001; 37(3): 851 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Koch, A. Kastrati, J. Mehilli, C. Bottiger, N. von Beckerath, and A. Schomig Insertion/Deletion Polymorphism of the Angiotensin I-Converting Enzyme Gene Is Not Associated With Restenosis After Coronary Stent Placement Circulation, July 11, 2000; 102(2): 197 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Okamura, M. Ohishi, H. Rakugi, T. Katsuya, Y. Yanagitani, S. Takiuchi, Y. Taniyama, K. Moriguchi, H. Ito, Y. Higashino, et al. Pharmacogenetic Analysis of the Effect of Angiotensin-Converting Enzyme Inhibitor on Restenosis After Percutaneous Transluminal Coronary Angioplasty Angiology, October 1, 1999; 50(10): 811 - 822. [Abstract] [PDF]
|
|
|
|
|
|
M. E. Bertrand and C. Bauters Cytomegalovirus Infection and Coronary Restenosis Circulation, March 16, 1999; 99(10): 1278 - 1279. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Challah, E. Villard, M. Philippe, A. Ribadeau-Dumas, B. Giraudeau, P. Janiak, J.-P. Vilaine, F. Soubrier, and J.-B. Michel Angiotensin I-Converting Enzyme Genotype Influences Arterial Response to Injury in Normotensive Rats Arterioscler. Thromb. Vasc. Biol., February 1, 1998; 18(2): 235 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ribichini, G. Steffenino, A. Dellavalle, G. Matullo, E. Colajanni, T. Camilla, A. Vado, G. Benetton, E. Uslenghi, and A. Piazza Plasma Activity and Insertion/Deletion Polymorphism of Angiotensin I–Converting Enzyme : A Major Risk Factor and a Marker of Risk for Coronary Stent Restenosis Circulation, January 20, 1998; 97(2): 147 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Van Belle, C. Bauters, E. Hubert, J.-C. Bodart, K. Abolmaali, T. Meurice, E. P. McFadden, J.-M. Lablanche, and M. E. Bertrand Restenosis Rates in Diabetic Patients : A Comparison of Coronary Stenting and Balloon Angioplasty in Native Coronary Vessels Circulation, September 2, 1997; 96(5): 1454 - 1460. [Abstract] [Full Text]
|
|
|
|
|
|
C. Amant, C. Bauters, J.-C. Bodart, J.-M. Lablanche, G. Grollier, N. Danchin, M. Hamon, F. Richard, N. Helbecque, E. P. McFadden, et al. D Allele of the Angiotensin I–Converting Enzyme Is a Major Risk Factor for Restenosis After Coronary Stenting Circulation, July 1, 1997; 96(1): 56 - 60. [Abstract] [Full Text]
|
|
|
|
|
|
B. Agerholm-Larsen, B. G. Nordestgaard, R. Steffensen, T. I.A. Sorensen, G. Jensen, and A. Tybjærg-Hansen ACE Gene Polymorphism: Ischemic Heart Disease and Longevity in 10 150 Individuals: A Case-Referent and Retrospective Cohort Study Based on the Copenhagen City Heart Study Circulation, May 20, 1997; 95(10): 2358 - 2367. [Abstract] [Full Text]
|
|