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(Circulation. 1995;91:1311-1312.)
© 1995 American Heart Association, Inc.

Articles

New Genetic Approaches

Establishing Resources for Research

Claude Lenfant, MD

	Introduction

 
The National Heart, Lung, and Blood Institute (NHLBI) is committed to a broad-ranging program of research that builds on past achievements and capitalizes on the most promising new approaches and technologies. Molecular genetics constitutes an area of particular interest because it has potential to directly enhance our mastery over cardiovascular, lung, and blood diseases. Moreover, an understanding of the molecular genetics of disease will provide vital new information to extend further the considerable contributions that have come from more traditional disciplines.

To guide its efforts in this emerging area, the Institute called upon an Expert Panel on Genetic Strategies for Heart, Lung, and Blood Diseases to formulate a Master Plan for the implementation of major research opportunities and strategies (see December 1993 Circulation). In this column, we highlight the development of two major initiatives recommended in the Master Plan: "Mammalian Genotyping Service" and "Genetic Map and Large Insert Library for the Rat Genome."

	Mammalian Genotyping Service

 
The Master Plan identified the need for an efficient, rapid genotyping service to support projects that exploit genetic linkage analyses, association studies, and mutational analysis in an effort to identify the genetic determinants of cardiovascular, lung, and blood diseases. One of the requirements of such studies is large-scale genotyping of populations and pedigrees. At the present time, genotypes typically are determined by investigators in their own laboratories by manual techniques. This work is costly and, because of its repetitive nature, often lacking in quality control. Moreover, robust software for the documentation of genotypes is rarely used, . . . [Full Text of this Article]

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