Circulation, Vol 89, 2283-2289, Copyright © 1994 by American Heart Association
DG Van Wylen
The purpose of this study was to determine the effect of ischemic
preconditioning on the changes in interstitial fluid (ISF) purine
metabolites and lactate during prolonged regional myocardial ischemia. The
study consisted of two groups of anesthetized dogs: a control group (n =
13) that was exposed to 60 minutes of regional myocardial ischemia and a
preconditioned group (n = 10). In the preconditioned group, regional
myocardial ischemia was induced for two 5-minute episodes, each followed by
10 minutes of reperfusion. These preconditioning episodes were followed by
60 minutes of sustained regional ischemia. Cardiac ISF was sampled by
microdialysis probes implanted in the left ventricular myocardium;
dialysate levels served as indices of ISF concentrations. In the
preconditioned group, dialysate concentrations of adenosine, inosine,
hypoxanthine, total purines, and lactate increased during each of the
5-minute ischemia episodes, with further increases occurring during the
first 5 minutes of reperfusion. However, the increases in dialysate purine
metabolites during the first period of ischemia/reperfusion were greater
than those that occurred during the second ischemia/reperfusion. In
addition, preconditioning reduced the rate of ISF purine metabolite and
lactate accumulation during the prolonged ischemia when compared with
nonpreconditioned animals. These data suggest that preconditioning reduces
the energy imbalance that occurs during subsequent myocardial ischemia and
thereby diminishes the rate of net adenine nucleotide degradation and
cellular production and release of purine metabolites and lactate. In
addition, the increase in ISF adenosine seen during the preconditioning
episode is consistent with the notion that preconditioning-induced
cardioprotection is mediated in part by the action of adenosine at
extracellular A1 adenosine receptors.
ARTICLES
Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia
Department of Physiology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo 14215.
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