Circulation, Vol 89, 548-552, Copyright © 1994 by American Heart Association
SS Hull Jr, E Vanoli, PB Adamson, RL Verrier, RD Foreman and PJ Schwartz
Seven conscious dogs documented to be at high risk by the occurrence of
ventricular fibrillation (VF) during acute myocardial ischemia were
randomly assigned to 6 weeks of either daily exercise training or cage rest
followed by exercise training. After 6 weeks of daily treadmill training,
heart rate variability, a marker of vagal tone, increased by 74% (P <
.001); baroreflex sensitivity, a marker of the capability to reflexly
augment vagal activity, increased by 69% (P < .01); the repetitive
extrasystole threshold, a marker of ventricular electrical stability,
increased by 44% (P < .05). After exercise training, the incidence of
ventricular fibrillation during acute myocardial ischemia decreased by
100%, as all animals survived. Neither passage of time nor heart rate level
during ischemia contributed to the outcome. The most likely mechanism to
explain the striking change in risk status is the shift in autonomic
balance characterized by increased cardiac vagal activity, which was
previously shown to have an antifibrillatory effect. These results suggest
that exercise training in healthy individuals may decrease their likelihood
of developing lethal arrhythmias during acute myocardial ischemia.
ARTICLES
Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia
Department of Physiology, College of Medicine, University of Oklahoma Health Science Center, Oklahoma City 73190.
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