This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Merlet, P. Articles by Rande, J. L. Search for Related Content PubMed PubMed Citation Articles by Merlet, P. Articles by Rande, J. L.

Circulation, Vol 87, 1169-1178, Copyright © 1993 by American Heart Association

ARTICLES

Positron emission tomography with 11C CGP-12177 to assess beta- adrenergic receptor concentration in idiopathic dilated cardiomyopathy

P Merlet, J Delforge, A Syrota, E Angevin, B Maziere, C Crouzel, H Valette, D Loisance, A Castaigne and JL Rande
Service Hospitalier Frederic Joliot, CEA, Orsay, France.

BACKGROUND. Positron emission tomography (PET) with 11C-labeled CGP- 12177 (CGP) has been shown to have the potential to noninvasively measure beta-adrenergic receptor concentration in dog heart. The present study was undertaken to evaluate the clinical value of this technique. METHODS AND RESULTS. Eight normal subjects and 10 patients with heart failure related to an idiopathic cardiomyopathy were studied. Estimation of beta-receptor concentration was based on a graphic method applied on myocardial PET time-concentration curves obtained after an intravenous injection of 11C-CGP followed 30 minutes later by a coinjection of labeled and unlabeled CGP. The clinical tolerance of these injections was good. Left ventricular concentration of beta-receptors was decreased in patients compared with controls (3.12 +/- 0.51 versus 6.60 +/- 1.18 pmol/mL, respectively; p < 0.001). This 53% decrease agrees with previous in vitro data. In eight of the 10 patients, the beta-receptor concentration obtained from PET was compared with the beta-receptor density determined on left ventricular endomyocardial biopsy samples by in vitro binding technique using 3H- CGP-12177. Results obtained with both techniques were correlated (r = 0.79, p = 0.019). Moreover, decreased beta-receptor concentration correlated with the beta-contractile responsiveness to intracoronary dobutamine infusion (r = 0.83, p = 0.003), indicating a direct link between changes in the receptor number and its biological function. CONCLUSIONS. PET appears to be a safe and reliable method of assessing in vivo changes in the number of left ventricular beta-adrenergic receptor sites of patients with idiopathic cardiomyopathy.

This article has been cited by other articles:

				J. H. Caldwell, J. M. Link, W. C. Levy, J. E. Poole, and J. R. Stratton Evidence for Pre- to Postsynaptic Mismatch of the Cardiac Sympathetic Nervous System in Ischemic Congestive Heart Failure J. Nucl. Med., February 1, 2008; 49(2): 234 - 241. [Abstract] [Full Text] [PDF]

				T. Tsukamoto, K. Morita, M. Naya, M. Inubushi, C. Katoh, K. Nishijima, Y. Kuge, H. Okamoto, H. Tsutsui, and N. Tamaki Decreased Myocardial {beta}-Adrenergic Receptor Density in Relation to Increased Sympathetic Tone in Patients with Nonischemic Cardiomyopathy J. Nucl. Med., November 1, 2007; 48(11): 1777 - 1782. [Abstract] [Full Text] [PDF]

				D. Bier, M. H. Holschbach, W. Wutz, R. A. Olsson, and H. H. Coenen METABOLISM OF THE A1 ADENOSINE RECEPTOR POSITRON EMISSION TOMOGRAPHY LIGAND [18F]8-CYCLOPENTYL-3-(3-FLUOROPROPYL)-1-PROPYLXANTHINE ([18F]CPFPX) IN RODENTS AND HUMANS Drug Metab. Dispos., April 1, 2006; 34(4): 570 - 576. [Abstract] [Full Text] [PDF]

				S. Ohshima, S. Isobe, H. Izawa, M. Nanasato, A. Ando, A. Yamada, K. Yamada, T. S. Kato, K. Obata, A. Noda, et al. Cardiac Sympathetic Dysfunction Correlates With Abnormal Myocardial Contractile Reserve in Dilated Cardiomyopathy Patients J. Am. Coll. Cardiol., December 6, 2005; 46(11): 2061 - 2068. [Abstract] [Full Text] [PDF]

				P G Camici Coronary recanalisation, myocardial viability, and ventricular remodelling after infarction Heart, April 1, 2005; 91(4): 421 - 422. [Abstract] [Full Text] [PDF]

				S. D. Rosen, K. Murphy, A. P. Leff, V. Cunningham, R. J.S. Wise, L. Adams, A. J.S. Coats, and P. G. Camici Is central nervous system processing altered in patients with heart failure? Eur. Heart J., June 1, 2004; 25(11): 952 - 962. [Abstract] [Full Text] [PDF]

				M. Momose, S. Reder, D. M. Raffel, P. Watzlowik, H.-J. Wester, N. Nguyen, P. H. Elsinga, F. M. Bengel, J. Remien, and M. Schwaiger Evaluation of Cardiac {beta}-Adrenoreceptors in the Isolated Perfused Rat Heart Using (S)-11C-CGP12388 J. Nucl. Med., March 1, 2004; 45(3): 471 - 477. [Abstract] [Full Text]

				N. Spyrou, S. D. Rosen, F. Fath-Ordoubadi, R. Jagathesan, R. Foale, J. S. Kooner, and P. G. Camici Myocardial beta-adrenoceptor densityone month after acute myocardial infarctionpredicts left ventricular volumes at six months J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1216 - 1224. [Abstract] [Full Text] [PDF]

				P G Camici Imaging of cardiac adrenergic innervation Heart, September 1, 2002; 88(3): 209 - 210. [Full Text] [PDF]

				J. Delforge, D. Mesangeau, F. Dolle, P. Merlet, C. Loc'h, M. Bottlaender, R. Trebossen, and A. Syrota In Vivo Quantification and Parametric Images of the Cardiac {beta}-Adrenergic Receptor Density J. Nucl. Med., February 1, 2002; 43(2): 215 - 226. [Abstract] [Full Text] [PDF]

				M. Schafers, H. Lerch, T. Wichter, C. G. Rhodes, A. A. Lammertsma, M. Borggrefe, F. Hermansen, O. Schober, G.u. Breithardt, and P. G. Camici Cardiac sympathetic innervation in patients with idiopathic right ventricular outflow tract tachycardia J. Am. Coll. Cardiol., July 1, 1998; 32(1): 181 - 186. [Abstract] [Full Text] [PDF]

				M. Schafers, D. Dutka, C. G. Rhodes, A. A. Lammertsma, F. Hermansen, O. Schober, and P. G. Camici Myocardial Presynaptic and Postsynaptic Autonomic Dysfunction in Hypertrophic Cardiomyopathy Circ. Res., January 23, 1998; 82(1): 57 - 62. [Abstract] [Full Text] [PDF]