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Circulation, Vol 81, 1353-1361, Copyright © 1990 by American Heart Association
Y Kagaya, Y Kanno, D Takeyama, N Ishide, Y Maruyama, T Takahashi, T Ido and T Takishima
To investigate the effects of long-term pressure overload on regional
myocardial substrate use, we performed quantitative autoradiography using
2-deoxy-D-[U-14C]glucose (14C-DG) and beta-methyl[1- 14C]heptadecanoic acid
(14C-BMHDA) in conscious rats with a 10-week ascending aortic constriction.
Heart weight/body weight ratio increased by 27% in aortic-constricted rats
as compared with sham-operated rats (p less than 0.01). Myocardial 14C-DG
uptake increased (258 +/- 63 vs. 144 +/- 41 nCi/g, p less than 0.01, n = 6
for each group); however, 14C- BMHDA extraction decreased (251 +/- 69 vs.
342 +/- 75 nCi/g, p less than 0.05, n = 7 for each group) in
aortic-constricted rats as compared with sham-operated rats. In
sham-operated rats, both 14C-DG and 14C- BMHDA uptakes were higher in the
left ventricular anterior and lateral walls as compared with the posterior
wall or the interventricular septum. In aortic-constricted rats, 14C-DG
uptake also increased in the interventricular septum, as well as in the
left ventricular anterior and lateral walls, as compared with the posterior
wall. There was, however, no regional difference in 14C-BMHDA extraction
among these four regions. Myocardial blood flow distribution determined by
4-[N- methyl-14C]iodoantipyrine or myocyte width showed no regional
variations among the four regions, either in aortic-constricted or sham-
operated rats. Regional interstitial fibrosis was small in either group.
The present study suggests that myocardial substrate uptake is altered
nonhomogeneously, and that the nonhomogeneity is not because of regional
variations in blood flow distribution, myocyte hypertrophy, or interstitial
fibrosis. The results of angiotensin II-induced acute pressure overloading
in other sham-operated rats, in which a remarkable increase in myocardial
14C-BMHDA extraction (n = 3, p less than 0.01) and no difference in 14C-DG
uptake (n = 3) as compared with normotensive sham-operated rats were
elicited, suggest that the findings in aortic-constricted rats are not
direct responses to increased left ventricular pressure itself but rather
should be explained by still unknown factors related to prolonged pressure
overload.
ARTICLES
Effects of long-term pressure overload on regional myocardial glucose and free fatty acid uptake in rats. A quantitative autoradiographic study
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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