This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Benowitz, N. L. Articles by Sharp, D. S. Search for Related Content PubMed PubMed Citation Articles by Benowitz, N. L. Articles by Sharp, D. S.

Circulation, Vol 80, 1309-1312, Copyright © 1989 by American Heart Association

ARTICLES

Inverse relation between serum cotinine concentration and blood pressure in cigarette smokers

NL Benowitz and DS Sharp
Division of Clinical Pharmacology, Medical Service, San Francisco General Hospital Medical Center, CA 94110.

Blood pressure is, on average, lower in cigarette smokers than in nonsmokers. In a cross-sectional study of 288 normotensive bus drivers, we found a significant inverse correlation between serum cotinine (the major metabolite of nicotine) and systolic and diastolic blood pressure that could not be accounted for by age, body weight, or alcohol consumption. Over the observed range of cotinine values, the average decrease in blood pressure was 10.7 and 7.0 mm Hg for systolic and diastolic blood pressures, respectively. We suggest that cotinine be measured to assess the influence of cigarette smoking in epidemiologic studies of blood pressure.

This article has been cited by other articles:

				G T C Ko, J C N Chan, L W W Tsang, J A J H Critchley, and C S Cockram Smoking and diabetes in Chinese men Postgrad. Med. J., April 1, 2001; 77(906): 240 - 243. [Abstract] [Full Text]

				D.-H. Lee, M.-H. Ha, J.-R. Kim, and D. R. Jacobs Jr Effects of Smoking Cessation on Changes in Blood Pressure and Incidence of Hypertension : A 4-Year Follow-Up Study Hypertension, February 1, 2001; 37(2): 194 - 198. [Abstract] [Full Text] [PDF]

				J. Minami, T. Ishimitsu, and H. Matsuoka Effects of Smoking Cessation on Blood Pressure and Heart Rate Variability in Habitual Smokers Hypertension, January 1, 1999; 33(1): 586 - 590. [Abstract] [Full Text] [PDF]

				E. Kristal-Boneh, G. Harari, and M. S. Green Seasonal Change in 24-Hour Blood Pressure and Heart Rate Is Greater Among Smokers Than Nonsmokers Hypertension, September 1, 1997; 30(3): 436 - 441. [Abstract] [Full Text]

				K. Liu, K. J. Ruth, J. M. Flack, R. Jones-Webb, G. Burke, P. J. Savage, and S. B. Hulley Blood Pressure in Young Blacks and Whites: Relevance of Obesity and Lifestyle Factors in Determining Differences : The CARDIA Study Circulation, January 1, 1996; 93(1): 60 - 66. [Abstract] [Full Text]