Circulation, Vol 77, 1424-1431, Copyright © 1988 by American Heart Association
TE Raya, RG Gay, L Lancaster, M Aguirre, C Moffett and S Goldman
To determine the time course of changes in left ventricular diastolic
properties after a large myocardial infarction, we serially measured left
ventricular relaxation, chamber stiffness, and the ratio of left
ventricular cavity to wall volume (V/VW) after coronary artery ligation in
rats. Left ventricular relaxation was measured during the occlusion and
then both relaxation and chamber stiffness were measured at 3 hr, 24 hr,
and 3, 5, and more than 22 days after infarction. Left ventricular
pressures and left ventricular dP/dt were recorded with
micromanometer-tipped catheters. Left ventricular relaxation was measured
by computer digitization of the left ventricular pressure tracings and
averaged over 100 to 150 cardiac cycles. Five chamber stiffness constants
were calculated from pressure-volume curves that were obtained ex vivo. We
found ventricular relaxation prolonged for the first hour after coronary
occlusion; relaxation was maximally prolonged at 10 to 15 min after onset
of occlusion. After 1 hr relaxation returned to normal. However, by 5 days
ventricular relaxation was again prolonged. Left ventricular stiffness
constants were increased at 3 and 24 hr, resulting in a shift of the left
ventricular pressure-volume relation to the left. At 3 days after coronary
artery ligation, all stiffness constants and the pressure- volume relation
returned to normal. At more than 22 days the pressure- volume relation was
shifted to the right and the stiffness constant for low filling pressures
was decreased. V/VW was significantly decreased from 0.603 +/- 0.021 at 3
and 24 hr to 0.379 +/- 0.024 and 0.362 +/- 0.032, respectively. V/VW was
significantly increased at more than 22 days (0.921 +/- 0.094).(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Serial changes in left ventricular relaxation and chamber stiffness after large myocardial infarction in rats
Department of Internal Medicine, Tucson Veterans Administration Medical Center, AZ 85723.
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