This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bakris, G. L. Articles by Burnett, J. C. Search for Related Content PubMed PubMed Citation Articles by Bakris, G. L. Articles by Burnett, J. C., Jr

Circulation, Vol 74, 1061-1065, Copyright © 1986 by American Heart Association

ARTICLES

The renal, forearm, and hormonal responses to standing in the presence and absence of propranolol

GL Bakris, DM Wilson and JC Burnett Jr

Nine normal volunteers underwent assessment of renal, forearm, and hormonal responses to orthostasis (quiet standing) in the presence and absence of 1 week of oral propranolol (160 mg/day). This was done to test the hypothesis that physiologic decrements in renal function (glomerular filtration rate, effective renal plasma flow, and absolute urinary sodium excretion) are attenuated by propranolol during quiet standing. The present studies, however, demonstrate that propranolol exaggerates the physiologic decrement in glomerular filtration rate, effective renal plasma flow, and absolute urinary sodium excretion during orthostasis. Forearm and renal vascular resistances were also accentuated in the presence of propranolol during quiet standing. These responses were associated with significant increases in plasma norepinephrine. We conclude that long-term administration of propranolol accentuates the physiologic decrement in renal hemodynamic and excretory function as well as in the forearm hemodynamic response to orthostasis in normal subjects.

This article has been cited by other articles:

				S. G. Chrysant Fixed Low-Dose Drug Combination for the Treatment of Hypertension Arch Fam Med, July 1, 1998; 7(4): 370 - 376. [Abstract] [Full Text] [PDF]

				M. Epstein and G. Bakris Newer Approaches to Antihypertensive Therapy: Use of Fixed-Dose Combination Therapy Arch Intern Med, September 23, 1996; 156(17): 1969 - 1978. [Abstract] [PDF]

				L. A. Lipsitz, E. R. Marks, J. Koestner, P. V. Jonsson, and J. Y. Wei Reduced Susceptibility to Syncope During Postural Tilt in Old Age: Is Beta-blockade Protective? Arch Intern Med, December 1, 1989; 149(12): 2709 - 2712. [Abstract] [PDF]