This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Green, M. S. Articles by Tyroler, H. A. Search for Related Content PubMed PubMed Citation Articles by Green, M. S. Articles by Tyroler, H. A.

Circulation, Vol 72, 93-104, Copyright © 1985 by American Heart Association

ARTICLES

The ratio of plasma high-density lipoprotein cholesterol to total and low-density lipoprotein cholesterol: age-related changes and race and sex differences in selected North American populations. The Lipid Research Clinics Program Prevalence Study

MS Green, G Heiss, BM Rifkind, GR Cooper, OD Williams and HA Tyroler

The distribution of the ratios of plasma high-density lipoprotein cholesterol (HDL-C) to total cholesterol (TC) and of HDL-C to low- density lipoprotein cholesterol (LDL-C) are presented for 6900 white and 495 black examinees greater than 4 years old. Measurements were obtained during the visit 2 survey of the Lipid Research Clinics (LRC) Program Prevalence Study, and correspond to a 15% random sample of 60,502 participants screened during the LRC visit 1 survey. Age- specific means, medians, and selected percentiles are given by sex and by gonadal hormone use in white women. Apparent in these cross- sectional data was a consistent age-related decline in the ratio of HDL- C to TC for white male participants, from a mean of 0.360 in the age group 5 to 9 to a mean of 0.211 in the age group 50 to 54. Thereafter the mean ratio increased slightly. In white women not using gonadal hormones the age-related decline in the ratio was only evident starting at the age group 35 to 39, from which it declines from 0.329 to 0.258 in the age group 55 to 59. White women using gonadal hormones showed very minor age-related changes in the HDL-C/TC ratio, varying around a mean of 0.300. The number of blacks examined was low and thus the racial comparisons must be interpreted with caution. For each gender, age-related trends were similar in black and white study participants. Black men, however, had a higher percentage of TC carried as HDL-C than white men in all age groups examined. Black women had a higher percentage of TC in HDL-C than white women only below age 20; in the adult age range no appreciable differences were seen. Pearson correlation coefficients between the lipid, lipoprotein, and lipoprotein ratios are presented. The ratio HDL-C/TC correlated highly with the ratio HDL-C/LDL-C (greater than 0.92 for all groups) and the former may be a more conveniently determined surrogate for the latter. Although not exhaustive regarding the information it conveys about a lipid pattern, the ratio HDL-C/TC has the advantage of summarizing complex associations into a single numerical approximation.

This article has been cited by other articles:

				M. A. Harris, M. T. Cosulich, M. J. Gillespie, K. K. Whitehead, T. I. Liu, P. M. Weinberg, and M. A. Fogel Pre-Fontan cardiac magnetic resonance predicts post-Fontan length of stay and avoids ionizing radiation J. Thorac. Cardiovasc. Surg., October 1, 2009; 138(4): 941 - 947. [Abstract] [Full Text] [PDF]

				T. Nakamura, A. Fox-Robichaud, R. Kikkawa, A. Kashiwagi, H. Kojima, M. Fujimiya, and N. C. W. Wong Transcription factors and age-related decline in apolipoprotein A-I expression J. Lipid Res., September 1, 1999; 40(9): 1709 - 1718. [Abstract] [Full Text]

				Y.-C. Chan, M. Suzuki, and S. Yamamoto A Comparison of Anthropometry, Biochemical Variables and Plasma Amino Acids among Centenarians, Elderly and Young Subjects J. Am. Coll. Nutr., August 1, 1999; 18(4): 358 - 365. [Abstract] [Full Text] [PDF]

				B. Lamarche, S. Moorjani, P. J. Lupien, B. Cantin, P.-M. Bernard, G. R. Dagenais, and J.-P. Despres Apolipoprotein A-I and B Levels and the Risk of Ischemic Heart Disease During a Five-Year Follow-up of Men in the Quebec Cardiovascular Study Circulation, August 1, 1996; 94(3): 273 - 278. [Abstract] [Full Text]

				S. Y. Choi, P. Sivaram, D. E. Walker, L. K. Curtiss, D. G. Gretch, S. L. Sturley, A. D. Attie, R. J. Deckelbaum, and I. J. Goldberg Lipoprotein Lipase Association with Lipoproteins Involves Protein-Protein Interaction with Apolipoprotein B J. Biol. Chem., April 7, 1995; 270(14): 8081 - 8086. [Abstract] [Full Text] [PDF]

				P. Zimetbaum, W. Frishman, and M. Aronson Lipids, Vascular Disease, and Dementia With Advancing Age: Epidemiologic Considerations Arch Intern Med, February 1, 1991; 151(2): 240 - 244. [Abstract] [PDF]