Circulation, Vol 71, 1038-1047, Copyright © 1985 by American Heart Association
DC Homans, R Asinger, KJ Elsperger, D Erlien, E Sublett, F Mikell and RJ Bache
To determine whether function is depressed in areas of myocardium adjacent
to an area of myocardial ischemia, 16 open-chest dogs were studied with
both two-dimensional echocardiography and ultrasonic microcrystals.
Regional myocardial blood flow was measured with radioactive microspheres
during control periods and after coronary arterial ligation. Segments of
myocardium adjacent to the area of ischemia were found to have no
significant change in transmural blood flow (1.02 +/- 0.38 ml/g/min control
vs 0.95 +/- 0.3 ml/g/min after ligation) or subendocardial flow (1.18 +/-
0.41 ml/g/min control vs. 1.19 +/- 0.37 ml/g/min after ligation). Regional
function assessed echocardiographically as percent change in segment area
was significantly depressed in these normally perfused adjacent areas (69.5
+/- 18.8% control vs 52.5 +/- 19.8% after ligation; p less than .01). There
was a significant relationship between proximity to border of infarction
and degree of adjacent dysfunction (r = .50, p less than .01 for
echocardiography; r = .70, p less than .01 for ultrasonic microcrystals).
It is concluded that systolic performance is depressed in nonischemic
myocardium directly adjacent to the lateral border of an area of acute
myocardial ischemia.
ARTICLES
Regional function and perfusion at the lateral border of ischemic myocardium
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