Circulation, Vol 71, 543-550, Copyright © 1985 by American Heart Association
R Rokey, LC Kuo, WA Zoghbi, MC Limacher and MA Quinones
To determine the relationship between Doppler-derived flow velocity through
the mitral anulus and angiographic parameters of left ventricular filling,
30 patients were studied by two-dimensional echocardiography combined with
pulsed Doppler echocardiography followed within 1 hr by left ventricular
angiography. The average heart rate for each test was 69 beats/min.
Doppler-derived parameters included: early peak diastolic velocity (E) and
peak atrial velocity, peak filling rate computed as E X cross-sectional
area of the mitral anulus derived from the annular diameter, normalized
peak filling rate computed as peak filling rate divided by the left
ventricular end-diastolic volume determined by two-dimensional
echocardiography, and half filling fraction derived from the time-velocity
integral of the Doppler- determined velocity curve. Frame-by-frame left
ventricular volumes were obtained throughout diastole from single-plane
cineangiograms. A volume- time curve with its derivative was generated by
computer processing from which peak filling rate, normalized peak filling
rate, and half filling fraction were measured. Morphologically, the
Doppler-derived velocity profile resembled the derivative of the
angiographic volume curve. In patients with reduced angiographic peak
filling rates, early peak diastolic velocity was often decreased less than
45 cm/sec with a relative increase in peak atrial velocity resulting in an
early peak diastolic velocity to peak atrial velocity ratio less than 1.0.
There were no significant differences in mean values for peak filling rate,
normalized peak filling rate, and half filling fraction by Doppler
echocardiography vs angiography (296 vs 283 ml/sec, 1.9 vs 2.0 sec-1 and
0.55 vs 0.55, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Determination of parameters of left ventricular diastolic filling with pulsed Doppler echocardiography: comparison with cineangiography
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