Circulation, Vol 64, 477-482, Copyright © 1981 by American Heart Association
O de Divitiis, S Fazio, M Petitto, G Maddalena, F Contaldo and M Mancini
We studied 10 obese volunteers, mean age 36.5 +/- 10.3 years, who weighed
123.56 +/- 28.7 g and were 69.96 +/- 22.5 kg overweight. The subjects did
not have diabetes, arterial hypertension or signs of cardiac and
respiratory failure or disease and all underwent right- and left-heart
catheterization. cardiac output and stroke volume were high, according to
increased oxygen consumption and to the degree of obesity. Ventricular
end-diastolic and atrial pressures ranged from normal to high and
correlated with body weight, signs of volume overloading and reduced left
ventricular (LV) compliance. The mean pulmonary artery pressure was
elevated and correlated well with weight, pulmonary resistance being
normal; mean aortic pressure did not correlate with weight, and systemic
arterial resistance tended to have a negative correlation. The LV function
curve showed impaired ventricular function, particularly for the heaviest
subjects, in whom Vmax and the ratio of the stroke work index to LV
end-diastolic pressure were reduced. These indexes correlated well with
each other and both correlated negatively with the degree of obesity. In
contrast, maximal dP/dt was normal and did not correlate with excess
weight. These observations show that depressed LV function is already
present in relatively young obese people, even if they are free from signs
of cardiopathy and other associate diseases. The degree of impairment of
heart function seems to parallel the degree of obesity.
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