Circulation, Vol 63, 546-551, Copyright © 1981 by American Heart Association
V Fuster, JH Chesebro, RL Frye and LR Elveback
Cigarette smoking or a strong family history of coronary disease was
present in 46 of 50 symptomatic patients with coronary artery disease who
were younger than 50 years of age. We recorded a shortened platelet
survival half-life (less than 92 hours) with 51Cr in 60% of these patients,
in 56% of apparently normal persons of the same age who smoked or had a
strong family history of coronary disease, and in only 14% of normal
persons who did not smoke and had no family history (p less than 0.01).
Lengthening of the shortened platelet survival toward normal occurred in
coronary patients given dipyridamole plus aspirin and in apparently normal
smokers who discontinued smoking (p less than 0.01). The study suggests a
possible relationship among cigarette smoking, strong family history of
coronary disease and platelet activation in the process of coronary
atherogenesis in the young adult.
ARTICLES
Platelet survival and the development of coronary artery disease in the young adult: effects of cigarette smoking, strong family history and medical therapy
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