Circulation, Vol 62, 55-60, Copyright © 1980 by American Heart Association
WM Savin, WL Haskell, JS Schroeder and EB Stinson
The electrocardiographic and ventilatory responses of 15 denervated heart
patients who had undergone cardiac transplantation and 14 age- matched,
normally innervated men were compared to assess the pattern of response to
graded treadmill exercise. A 5-minute postexercise venous lactate sample
was also obtained. Respiratory exchange ratio and ventilation (Ve) were
higher in denervated patients than in normals during submaximal exercise.
Peak values (normals vs denervated) for heart rate (172 vs 159 beats/min),
blood pressure (189 vs 167 mm Hg), oxygen uptake (37 vs 25 ml/kg/min),
oxygen pulse (0.22 vs 0.16 ml/kg/beat) and work time (26.2 vs 18.0 minutes)
were higher in normals than in cardiac transplant recipients. Peak
ventilatory equivalent (2.14 vs 3.13 l/ml/kg) and lactate values were
higher for transplants than for normal subjects, but there were no
significant intergroup differences in peak Ve or in the respiratory
exchange ratio. In cardiac transplant recipients, work time correlated
inversely with a measure of rejection history (r = -0.59, p less than
0.01). The response of cardiac transplant recipients to treadmill work
differs from that of normal men and reflects a diminished ability to meet
the oxygen demands of the exercising periphery.
ARTICLES
Cardiorespiratory responses of cardiac transplant patients to graded, symptom-limited exercise
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