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Circulation, Vol 59, 8-13, Copyright © 1979 by American Heart Association
WB Kannel and DL McGee
The impact of cardiovascular disease was compared in non-diabetics and
diabetics in the Framingham cohort. In the first 20 years of the study
about 6% of the women and 8% of the men were diagnosed as diabetics. The
incidence of cardiovascular disease among diabetic men was twice that among
non-diabetic men. Among diabetic women the incidence of cardiovascular
disease was three times that among non-diabetic women. Judging from a
comparison of standardized coefficients for the regression of incidence of
cardiovascular disease on specified risk factors, there is no indication
that the relationship of risk factors to the subsequent development of
cardiovascular disease is different for diabetics and non-diabetics. This
study suggests that the role of diabetes as a cardiovascular risk factor
does not derive from an altered ability to contend with known risk factors.
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Diabetes and cardiovascular risk factors: the Framingham study
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