Circulation, Vol 55, 767-772, Copyright © 1977 by American Heart Association
WP Castelli, JT Doyle, T Gordon, CG Hames, MC Hjortland, SB Hulley, A Kagan and WJ Zukel
The relation between coronary heart disease (CHD) prevalence and fasting
lipid levels was assessed by a case-control study in five populations with
a total of 6859 men and women of black, Japanese and white ancestry drawn
from subjects aged 40 years and older from populations in Albany,
Framingham, Evans County, Honolulu and San Francisco. In each major study
group mean levels of high density lipoprotein (HDL) cholesterol were lower
in persons with CHD than in those without the disease. The average
difference was small -- typically 3-4 mg/dl -- but statistically
significant. It was found in most age-race-sex specific groups. The inverse
HDL cholesterol-CHD association was not appreciably diminished when
adjusted for levels of low density lipoprotein (LDL) cholesterol and
triglyceride. LDL, totoal cholesterol and triglycerides were directly
related to CHD prevalence; surprisingly, these findings were less uniformly
present in the various study groups than the inverse HDL cholesterol-CHD
association.
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HDL cholesterol and other lipids in coronary heart disease. The cooperative lipoprotein phenotyping study
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S. B. Hulley, R. Cohen, and G. Widdowson Plasma High-Density Lipoprotein Cholesterol Level: Influence of Risk Factor Intervention JAMA, November 21, 1977; 238(21): 2269 - 2271. [Abstract] [PDF] |
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T. GORDON, W. P. CASTELLI, M. C. HJORTLAND, W. B. KANNEL, and T. R. DAWBER Diabetes, Blood Lipids, and the Role of Obesity in Coronary Heart Disease Risk for Women: The Framingham Study Ann Intern Med, October 1, 1977; 87(4): 393 - 397. [Abstract] [PDF] |
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Y. Ueda, E. Gong, L. Royer, P. N. Cooper, O. L. Francone, and E. M. Rubin Relationship between Expression Levels and Atherogenesis in Scavenger Receptor Class B, Type I Transgenics J. Biol. Chem., June 30, 2000; 275(27): 20368 - 20373. [Abstract] [Full Text] [PDF] |
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H.-Y. Kan, S. Georgopoulos, and V. Zannis A Hormone Response Element in the Human Apolipoprotein CIII (ApoCIII) Enhancer Is Essential for Intestinal Expression of the ApoA-I and ApoCIII Genes and Contributes to the Hepatic Expression of the Two Linked Genes in Transgenic Mice J. Biol. Chem., September 22, 2000; 275(39): 30423 - 30431. [Abstract] [Full Text] [PDF] |
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