Circulation, Vol 55, 525-533, Copyright © 1977 by American Heart Association
T Sakamoto and T Yamada
Dobutamine, a new synthetic inotropic agent, was administered by
intravenous infusion to 22 patients following open heart surgery. The
dosage of dobutamine started from 2 mug/kg/min and was increased stepwise
to 4, 6, and 8 mug/kg/min. Cardiac index increased from 2.54 +/- 0.13 to
3.11 +/- 0.19 and 3.50 +/- 0.22 L/min/m2 with 4 and 8 mug/kg/min,
respectively. Heart rate increased from 87.6 +/- 2.9 to 96.4 +/- 2.3 and
108.9 +/- 3.2 beats/min with 4 and 8 mug/kg/min, respectively. Systolic and
mean aortic pressure and systolic pulmonary arterial pressure were elevated
from 126.0 +/- 3.8 to 144.6 +/- 6.0 mm Hg, from 91.8 +/- 2.7 to 96.2 +/-
3.2 mm Hg, and from 33.4 +/- 2.3 to 37.1 +/- 2.5 mm Hg with 8 mug/kg/min,
while other pressures were unchanged. Mean left atrial pressure fell
significantly from 15.9 +/- 0.6 to 14.8 +/- 0.7 mm Hg. Stroke volume index,
stroke work index, and left ventricular work also increased. Premature
ventricular beats were observed in only one patient during dobutamine
infusion, but no other side effect was observed. We conclude that
dobutamine is a potent inotropic agent which increases cardiac output
without causing significant tachycardia or arrhythmias, and is useful for
the treatment of patients following open heart surgery.
ARTICLES
Hemodynamic effects of dobutamine in patients following open heart surgery
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