Circulation, Vol 54, 309-318, Copyright © 1976 by American Heart Association
SR Srinivasan, RR Frerichs, LS Webber and GS Berenson
Serum lipoprotein profiles in 3182 children, ages 5-14 years, were studied
in a biracial community as part of the Bogalusa Heart Study to describe the
early natural history of atherosclerosis. White and black children showed
similar mean levels of beta-lipoproteins. Pre-beta- lipoprotein levels,
however, were significantly higher in white shildren, while significantly
higher levels of alpha-lipoprotein were found in black children. Girls had
generally higher levels of beta- and pre-beta-lipoprotein and lower levels
of alpha-lipoprotein than boys, although the differences were not
significant at each age group. With age there was little change in
alpha-lipoprotein levels, a significant increase in pre-beta-lipoprotein
levels and a slight but significant decrease between 11 and 14 years in
beta-lipoprotein levels. The correlation of alpha-lipoprotein was negative
with beta-lipoprotein and, to a greater extent, with pre-beta-lipoprotein.
The above inverse relationships were significantly greater in white
children than in black children, suggesting differences in lipoprotein
profiles in the two groups. Lipoprotein values from a total community study
are now available for comparison with the currently recommended upper
normal limits for lipoproteins. Since only a very small percentage of
children could be considered as hyperlipoproteinemic by those specific
levels in this community, we suggest that distributions and percentiles be
used to evaluate children for hyperlipoproteinemia.
ARTICLES
Serum lipoprotein profile in children from a biracial community: the Bogalusa Heart Study
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