Circulation, Vol 51, 1107-1113, Copyright © 1975 by American Heart Association
The rate at which arterial pressure rises after discontinuing active
treatment was investigated in a group of 86 hypertensive patients who
received treatment with hydrochlorothiazide, reserpine and hydralazine for
two years or longer and whose diastolic pressures averaged below 96 mm Hg
for the last year of treatment. Sixty patients were assigned double-blind
to placebos and 26 were continued on active drugs. Forty- two of the
placebo group of patients were removed over an 18 month follow-up because
of return of elevated blood pressures, 39 being removed in the first six
months. Six patients in the placebo group and none in the treated group
were removed because of morbid events. Nine or 15% of the placebo patients
remained normotensive. The rate of rise in arterial pressure in the placebo
group appeared to be related directly to the height of the pressure prior
to initiation of active treatment and inversely to the age of the patients.
Serum uric acid fell significantly while serum potassium rose significantly
after active treatment was discontinued. The glucose tolerance test changed
slightly in a direction toward normal while serum creatinine showed no
significant change.
ARTICLES
Return of elevated blood pressure after withdrawal of antihypertensive drugs
This article has been cited by other articles:
 |
|
 |
|
  K. Bishu, K. M. Gricz, S. Chewaka, and R. Agarwal Appropriateness of Antihypertensive Drug Therapy in Hemodialysis Patients Clin. J. Am. Soc. Nephrol., July 1, 2006; 1(4): 820 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R Nelson, C. M Reid, H. Krum, T. Muir, P. Ryan, and J. J McNeil Predictors of normotension on withdrawal of antihypertensive drugs in elderly patients: prospective study in second Australian national blood pressure study cohort BMJ, October 12, 2002; 325(7368): 815 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Alsop and M Mac Mahon Withdrawing cardiovascular medications at a syncope clinic Postgrad. Med. J., June 1, 2001; 77(908): 403 - 405. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. S. Trilling and J. Froom The Urgent Need to Improve Hypertension Care Arch Fam Med, September 1, 2000; 9(9): 794 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Perry, E. D. Freis, and E. D. Frohlich Department of Veterans Affairs Hypertension Meeting : A Proposal for Improved Care Hypertension, April 1, 2000; 35(4): 853 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Espeland, P. K. Whelton, J. B. Kostis, J. L. Bahnson, W. H. Ettinger, J. A. Cutler, L. J. Appel, S. Kumanyika, D. Farmer, J. Elam, et al. Predictors and Mediators of Successful Long-term Withdrawal From Antihypertensive Medications Arch Fam Med, May 1, 1999; 8(3): 228 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Zell and C. K. Lardinois Treatment of Mild Hypertension: Decision Before Drugs Arch Fam Med, July 1, 1993; 2(7): 778 - 786. [Abstract] [PDF]
|
|
|
|
 |
|
 R. E. Schmieder, J. K. Rockstroh, and F. H. Messerli Antihypertensive Therapy: To Stop or Not to Stop? JAMA, March 27, 1991; 265(12): 1566 - 1571. [Abstract] [PDF]
|
|
|
|
 |
|
 M. S. Kochar, K. M. Landry, and S. M. Ristow Effects of Reduction in Dose and Discontinuation of Hydrochlorothiazide in Patients With Controlled Essential Hypertension Arch Intern Med, May 1, 1990; 150(5): 1009 - 1011. [Abstract] [PDF]
|
|
|
|
|
|
T. D. Giles, G. E. Sander, L. Roffidal, M. G. Thomas, D. P. Mersch, R. R. Moyer, J. F. Burris, W. J. Mroczek, and J. Brachfeld Remission of Mild to Moderate Hypertension After Treatment With Carteolol, a {beta}-Adrenoceptor Blocker With Intrinsic Sympathomimetic Activity Arch Intern Med, August 1, 1988; 148(8): 1725 - 1728. [Abstract] [PDF]
|
|
|
|
|
|
A. L. Dannenberg and W. B. Kannel Remission of Hypertension: The 'Natural' History of Blood Pressure Treatment in the Framingham Study JAMA, March 20, 1987; 257(11): 1477 - 1483. [Abstract] [PDF]
|
|
|
|
|
|
R. Stamler, J. Stamler, R. Grimm, F. C. Gosch, P. Elmer, A. Dyer, R. Berman, J. Fishman, N. Van Heel, J. Civinelli, et al. Nutritional Therapy for High Blood Pressure: Final Report of a Four-Year Randomized Controlled Trial-- The Hypertension Control Program JAMA, March 20, 1987; 257(11): 1484 - 1491. [Abstract] [PDF]
|
|
|
|
|
|
W. J. Mroczek and J. F. Burris Nonpharmacologic Treatment of Hypertension Arch Intern Med, September 1, 1985; 145(9): 1741 - 1743. [Abstract] [PDF]
|
|
|
|
|
|
H. G. Langford, M. D. Blaufox, A. Oberman, C. M. Hawkins, J. D. Curb, G. R. Cutter, S. Wassertheil-Smoller, S. Pressel, C. Babcock, J. D. Abernethy, et al. Dietary Therapy Slows the Return of Hypertension After Stopping Prolonged Medication JAMA, February 1, 1985; 253(5): 657 - 664. [Abstract] [PDF]
|
|
|
|
|
|
P. D. Levinson and E. D. Freis BP and Hypertension Arch Intern Med, April 1, 1984; 144(4): 856 - 856. [Abstract] [PDF]
|
|
|
|
|
|
F. A. Finnerty Jr Step-Down Therapy in Hypertension: Importance in Long-term Management JAMA, December 4, 1981; 246(22): 2593 - 2596. [Abstract] [PDF]
|
|
|
|
 |
|
 H. M. PERRY JR. Minoxidil and Improvement of Renal Function in Uremic Malignant Hypertension Ann Intern Med, November 1, 1980; 93(5): 769 - 771. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Mitchell Perry JR Veterans Administration Cooperative Studies of Hypertension Angiology, November 1, 1978; 29(11): 804 - 816. [PDF]
|
|
|
|
|
|
M. H. Alderman and O. S. Ochs Treatment of Hypertension at the University Medical Clinic Arch Intern Med, December 1, 1977; 137(12): 1707 - 1710. [Abstract] [PDF]
|
|