This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by PARKER, J. O. Articles by WEST, R. O. Search for Related Content PubMed PubMed Citation Articles by PARKER, J. O. Articles by WEST, R. O.

(Circulation. 1966;33:17.)
© 1966 American Heart Association, Inc.

---

Hemodynamic Effects of Aminophylline in Cor Pulmonale

JOHN O. PARKER M.D.¹; KUMAR KELKAR M.D.¹; ROXROY O. WEST M.D.¹

¹ From the Cardiopulmonary Laboratory, Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Nine patients with cor pulmonale due to chronic obstructive pulmonary disease were studied by means of right and left heart catheterization. Hemodynamic and respiratory observations were made during a control period and during the infusion of 1 g of aminophylline.

Aminophylline produced a significant reduction in mean pulmonary artery pressure from 39.4 to 25.4 mm Hg, in right ventricular end-diastolic pressure from 8.6 to 2.1 mm Hg, in left ventricular end-diastolic pressure from 7.9 to 3.0 mm Hg, and in brachial artery mean pressure from 95.3 to 85.6 mm Hg. The heart rate and oxygen consumption increased, but there was no change in cardiac index. The alveolar ventilation increased significantly from 2.1 to 2.9 L/min/m² (BTPS).

Evidence is presented to suggest that the decrease in pulmonary artery pressure was due to pulmonary arteriolar dilatation.

This article has been cited by other articles:

				L. H. GREEN and T. W. SMITH The Use of Digitalis in Patients with Pulmonary Disease Ann Intern Med, October 1, 1977; 87(4): 459 - 465. [Abstract] [PDF]