This Article Full Text Full Text (PDF) All Versions of this Article: 116/7/755    most recent CIRCULATIONAHA.107.698258v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Webb, J. G. Articles by Lichtenstein, S. V. Search for Related Content PubMed PubMed Citation Articles by Webb, J. G. Articles by Lichtenstein, S. V. Related Collections Other heart failure Catheter-based coronary and valvular interventions: other CV surgery: valvular disease Related Article

(Circulation. 2007;116:755-763.)
© 2007 American Heart Association, Inc.

Valvular Heart Disease

Percutaneous Transarterial Aortic Valve Replacement in Selected High-Risk Patients With Aortic Stenosis

John G. Webb, MD; Sanjeevan Pasupati, MBChB; Karin Humphries, PhD; Christopher Thompson, MD; Lukas Altwegg, MD; Robert Moss, MD; Ajay Sinhal, MD; Ronald G. Carere, MD; Brad Munt, MD; Donald Ricci, MD; Jian Ye, MD; Anson Cheung, MD; Sam V. Lichtenstein, MD, PhD

From the Divisions of Cardiology and Cardiac Surgery, St Paul’s Hospital and the Centre for Health Evaluation and Outcome Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Correspondence to John Webb, MD, Director, Cardiac Catheterization, St. Paul’s Hospital, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6. E-mail webb{at}providencehealth.bc.ca

Received February 22, 2007; accepted June 1, 2007.

Background— Percutaneous aortic valve replacement represents an endovascular alternative to conventional open heart surgery without the need for sternotomy, aortotomy, or cardiopulmonary bypass.

Methods and Results— Transcatheter implantation of a balloon-expandable stent valve using a femoral arterial approach was attempted in 50 symptomatic patients with severe aortic stenosis in whom there was a consensus that the risks of conventional open heart surgery were very high. Valve implantation was successful in 86% of patients. Intraprocedural mortality was 2%. Discharge home occurred at a median of 5 days (interquartile range, 4 to 13). Mortality at 30 days was 12% in patients in whom the logistic European System for Cardiac Operative Risk Evaluation risk score was 28%. With experience, procedural success increased from 76% in the first 25 patients to 96% in the second 25 (P=0.10), and 30-day mortality fell from 16% to 8% (P=0.67). Successful valve replacement was associated with an increase in echocardiographic valve area from 0.6±0.2 to 1.7±0.4 cm². Mild paravalvular regurgitation was common but was well tolerated. After valve insertion, there was a significant improvement in left ventricular ejection fraction (P<0.0001), mitral regurgitation (P=0.01), and functional class (P<0.0001). Improvement was maintained at 1 year. Structural valve deterioration was not observed with a median follow-up of 359 days.

Conclusion— Percutaneous valve replacement may be an alternative to conventional open heart surgery in selected high-risk patients with severe symptomatic aortic stenosis.

---

 

CLINICAL PERSPECTIVE

Related Article:

Issue Highlights
Circulation 2007 116: 685. [Extract] [Full Text]

This article has been cited by other articles:

				A. N. Azadani, N. Jaussaud, P. B. Matthews, L. Ge, T. S. Guy, T. A.M. Chuter, and E. E. Tseng Energy loss due to paravalvular leak with transcatheter aortic valve implantation. Ann. Thorac. Surg., December 1, 2009; 88(6): 1857 - 1863. [Abstract] [Full Text] [PDF]

				A. N. Azadani, N. Jaussaud, P. B. Matthews, L. Ge, T. S. Guy, T. A.M. Chuter, and E. E. Tseng Valve-in-Valve Implantation Using a Novel Supravalvular Transcatheter Aortic Valve: Proof of Concept. Ann. Thorac. Surg., December 1, 2009; 88(6): 1864 - 1869. [Abstract] [Full Text] [PDF]

				M. Portoghese Transcatheter aortic valve therapy is not aortic valve replacement. Ann. Thorac. Surg., December 1, 2009; 88(6): 2071 - 2072. [Full Text] [PDF]

				A. A. Klein, S. T. Webb, S. Tsui, C. Sudarshan, L. Shapiro, and C. Densem Transcatheter aortic valve insertion: anaesthetic implications of emerging new technology Br. J. Anaesth., December 1, 2009; 103(6): 792 - 799. [Abstract] [Full Text] [PDF]

				F. De Robertis, A. Asgar, S. Davies, N. Delahunty, A. Kelleher, R. Trimlett, M. Mullen, and N. Moat The left axillary artery -- a new approach for transcatheter aortic valve implantation Eur. J. Cardiothorac. Surg., November 1, 2009; 36(5): 807 - 812. [Abstract] [Full Text] [PDF]

				M. Thielmann, D. Wendt, H. Eggebrecht, P. Kahlert, P. Massoudy, M. Kamler, R. Erbel, H. Jakob, and S. Sack Transcatheter aortic valve implantation in patients with very high risk for conventional aortic valve replacement. Ann. Thorac. Surg., November 1, 2009; 88(5): 1468 - 1474. [Abstract] [Full Text] [PDF]

				S. Bleiziffer, H. Ruge, D. Mazzitelli, A. Hutter, A. Opitz, R. Bauernschmitt, and R. Lange Survival after transapical and transfemoral aortic valve implantation: Talking about two different patient populations J. Thorac. Cardiovasc. Surg., November 1, 2009; 138(5): 1073 - 1080. [Abstract] [Full Text] [PDF]

				H. A. Dwyer, P. B. Matthews, A. Azadani, L. Ge, T. S. Guy, and E. E. Tseng Migration forces of transcatheter aortic valves in patients with noncalcific aortic insufficiency J. Thorac. Cardiovasc. Surg., November 1, 2009; 138(5): 1227 - 1233. [Abstract] [Full Text] [PDF]

				J. Ye, J. G. Webb, A. Cheung, J.-B. Masson, R. G. Carere, C. R. Thompson, B. Munt, R. Moss, and S. V. Lichtenstein Transcatheter Valve-in-Valve Aortic Valve Implantation: 16-Month Follow-Up. Ann. Thorac. Surg., October 1, 2009; 88(4): 1322 - 1324. [Abstract] [Full Text] [PDF]

				T. G. Kelpis, N. E. Mezilis, V. N. Ninios, and A. A. Pitsis Minimally invasive transapical aortic valve-in-a-valve implantation for severe aortic regurgitation in a degenerated stentless bioprosthesis J. Thorac. Cardiovasc. Surg., October 1, 2009; 138(4): 1018 - 1020. [Full Text] [PDF]

				D. Wendt, S. Stuhle, H. Wendt, M. Thielmann, B. Kipfmuller, F. Hauck, B. Vogel, and H. Jakob Cutting precision in a novel aortic valve resection tool. Research in progress Interactive CardioVascular and Thoracic Surgery, October 1, 2009; 9(4): 672 - 676. [Abstract] [Full Text] [PDF]

				L. F Tops, V. Delgado, F. van der Kley, and J. J Bax Percutaneous aortic valve therapy: clinical experience and the role of multi-modality imaging Heart, September 15, 2009; 95(18): 1538 - 1546. [Full Text] [PDF]

				J. G. Dumesnil, P. Pibarot, and B. Carabello Paradoxical low flow and/or low gradient severe aortic stenosis despite preserved left ventricular ejection fraction: implications for diagnosis and treatment Eur. Heart J., September 8, 2009; (2009) ehp361v1. [Abstract] [Full Text] [PDF]

				J.-B. Masson, J. Kovac, G. Schuler, J. Ye, A. Cheung, S. Kapadia, M. E. Tuzcu, S. Kodali, M. B. Leon, and J. G. Webb Transcatheter Aortic Valve Implantation: Review of the Nature, Management, and Avoidance of Procedural Complications J. Am. Coll. Cardiol. Intv., September 1, 2009; 2(9): 811 - 820. [Abstract] [Full Text] [PDF]

				D. Detaint, L. Lepage, D. Himbert, E. Brochet, D. Messika-Zeitoun, B. Iung, and A. Vahanian Determinants of Significant Paravalvular Regurgitation After Transcatheter Aortic Valve Implantation: Impact of Device and Annulus Discongruence J. Am. Coll. Cardiol. Intv., September 1, 2009; 2(9): 821 - 827. [Abstract] [Full Text] [PDF]

				C. Fraccaro, M. Napodano, G. Tarantini, V. Gasparetto, G. Gerosa, R. Bianco, R. Bonato, D. Pittarello, G. Isabella, S. Iliceto, et al. Expanding the Eligibility for Transcatheter Aortic Valve Implantation: The Trans-Subclavian Retrograde Approach Using the III Generation CoreValve Revalving System J. Am. Coll. Cardiol. Intv., September 1, 2009; 2(9): 828 - 833. [Abstract] [Full Text] [PDF]

				T. Grebel and J. Schumm Job Matters: Differences in Risk Assessment of Percutaneous Aortic Valve Replacement Between Cardiologists and Cardiac Surgeons Circ Cardiovasc Qual Outcomes, September 1, 2009; 2(5): 465 - 468. [Abstract] [Full Text] [PDF]

				J. Leipsic, D. Wood, D. Manders, F. Nietlispach, J. B. Masson, J. Mayo, S. Al-Bugami, and J. G. Webb The Evolving Role of MDCT in Transcatheter Aortic Valve Replacement: A Radiologists' Perspective Am. J. Roentgenol., September 1, 2009; 193(3): W214 - W219. [Abstract] [Full Text] [PDF]

				R. Moreno, D. Dobarro, E. Lopez de Sa, M. Prieto, C. Morales, L. Calvo Orbe, I. Moreno-Gomez, D. Filgueiras, A. Sanchez-Recalde, G. Galeote, et al. Cause of Complete Atrioventricular Block After Percutaneous Aortic Valve Implantation: Insights From a Necropsy Study Circulation, August 4, 2009; 120(5): e29 - e30. [Full Text] [PDF]

				D. Wendt, B. R. Osswald, K. Kayser, M. Thielmann, P. Tossios, P. Massoudy, M. Kamler, and H. Jakob Society of Thoracic Surgeons score is superior to the EuroSCORE determining mortality in high risk patients undergoing isolated aortic valve replacement. Ann. Thorac. Surg., August 1, 2009; 88(2): 468 - 474. [Abstract] [Full Text] [PDF]

				H. A. Dwyer, P. B. Matthews, A. Azadani, N. Jaussaud, L. Ge, T. S. Guy, and E. E. Tseng Computational fluid dynamics simulation of transcatheter aortic valve degeneration Interactive CardioVascular and Thoracic Surgery, August 1, 2009; 9(2): 301 - 308. [Abstract] [Full Text] [PDF]

				T. Trepels, S. Martens, M. Doss, S. Fichtlscherer, and V. Schachinger Thrombotic Restenosis After Minimally Invasive Implantation of Aortic Valve Stent Circulation, July 28, 2009; 120(4): e23 - e24. [Full Text] [PDF]

				D. Himbert, F. Descoutures, N. Al-Attar, B. Iung, G. Ducrocq, D. Detaint, E. Brochet, D. Messika-Zeitoun, F. Francis, H. Ibrahim, et al. Results of transfemoral or transapical aortic valve implantation following a uniform assessment in high-risk patients with aortic stenosis. J. Am. Coll. Cardiol., July 21, 2009; 54(4): 303 - 311. [Abstract] [Full Text] [PDF]

				R. H. Bombien, M. Appel, T. Attmann, G.-R. Klaws, M. Schunke, C. Hass, J. Cremer, and G. Lutter Percutaneous aortic valve replacement: gross anatomy and histological findings after transapical and endoluminal resection of human aortic valves in situ Eur. J. Cardiothorac. Surg., July 1, 2009; 36(1): 112 - 117. [Abstract] [Full Text] [PDF]

				F. Aregger, P. Wenaweser, G. J. Hellige, A. Kadner, T. Carrel, S. Windecker, and F. J. Frey Risk of acute kidney injury in patients with severe aortic valve stenosis undergoing transcatheter valve replacement Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2175 - 2179. [Abstract] [Full Text] [PDF]

				H A Vargas, E T D Hoey, D Gopalan, S K B Agrawal, N J Screaton, and G S Gulati Congenital and acquired conditions of the aortic root: multidetector computed tomography features Postgrad. Med. J., July 1, 2009; 85(1005): 383 - 391. [Abstract] [Full Text] [PDF]

				J. G. Webb, L. Altwegg, R. H. Boone, A. Cheung, J. Ye, S. Lichtenstein, M. Lee, J. B. Masson, C. Thompson, R. Moss, et al. Transcatheter Aortic Valve Implantation: Impact on Clinical and Valve-Related Outcomes Circulation, June 16, 2009; 119(23): 3009 - 3016. [Abstract] [Full Text] [PDF]

				N. Al-Attar, D. Himbert, F. Descoutures, B. Iung, R. Raffoul, D. Messika-Zeitoun, E. Brochet, F. Francis, H. Ibrahim, A. Vahanian, et al. Transcatheter Aortic Valve Implantation: Selection Strategy Is Crucial for Outcome. Ann. Thorac. Surg., June 1, 2009; 87(6): 1757 - 1763. [Abstract] [Full Text] [PDF]

				K.-E. Klaaborg, H. Egeblad, C.-J. Jakobsen, K. Terp, C. Lindskov, H. R. Andersen, and L. Thuesen Transapical Transcatheter Treatment of a Stenosed Aortic Valve Bioprosthesis Using the Edwards SAPIEN Transcatheter Heart Valve. Ann. Thorac. Surg., June 1, 2009; 87(6): 1943 - 1946. [Abstract] [Full Text] [PDF]

				A. Zajarias and A. G. Cribier Outcomes and Safety of Percutaneous Aortic Valve Replacement J. Am. Coll. Cardiol., May 19, 2009; 53(20): 1829 - 1836. [Abstract] [Full Text] [PDF]

				J. G. Webb, L. Altwegg, J.-B. Masson, S. Al Bugami, A. Al Ali, and R. A. Boone A New Transcatheter Aortic Valve and Percutaneous Valve Delivery System J. Am. Coll. Cardiol., May 19, 2009; 53(20): 1855 - 1858. [Abstract] [Full Text] [PDF]

				M.-A. Clavel, J. G. Webb, P. Pibarot, L. Altwegg, E. Dumont, C. Thompson, R. De Larochelliere, D. Doyle, J.-B. Masson, S. Bergeron, et al. Comparison of the Hemodynamic Performance of Percutaneous and Surgical Bioprostheses for the Treatment of Severe Aortic Stenosis J. Am. Coll. Cardiol., May 19, 2009; 53(20): 1883 - 1891. [Abstract] [Full Text] [PDF]

				S. H. Rahimtoola The Year in Valvular Heart Disease J. Am. Coll. Cardiol., May 19, 2009; 53(20): 1894 - 1908. [Full Text] [PDF]

				V. Kurra, P. Schoenhagen, E. E. Roselli, S. R. Kapadia, E. M. Tuzcu, R. Greenberg, M. Akhtar, M. Y. Desai, S. D. Flamm, S. S. Halliburton, et al. Prevalence of significant peripheral artery disease in patients evaluated for percutaneous aortic valve insertion: Preprocedural assessment with multidetector computed tomography. J. Thorac. Cardiovasc. Surg., May 1, 2009; 137(5): 1258 - 1264. [Abstract] [Full Text] [PDF]

				F. T. Billings IV, S. K. Kodali, and J. S. Shanewise Transcatheter Aortic Valve Implantation: Anesthetic Considerations Anesth. Analg., May 1, 2009; 108(5): 1453 - 1462. [Abstract] [Full Text] [PDF]

				S. Bleiziffer, H. Ruge, D. Mazzitelli, C. Schreiber, A. Hutter, J.-C. Laborde, R. Bauernschmitt, and R. Lange Results of percutaneous and transapical transcatheter aortic valve implantation performed by a surgical team Eur. J. Cardiothorac. Surg., April 1, 2009; 35(4): 615 - 621. [Abstract] [Full Text] [PDF]

				D. Wendt, W. Muller, F. Hauck, M. Thielmann, H. Wendt, B. Kipfmuller, B. Vogel, and H. Jakob In vitro results of a new minimally invasive aortic valve resecting tool Eur. J. Cardiothorac. Surg., April 1, 2009; 35(4): 622 - 627. [Abstract] [Full Text] [PDF]

				M. Akhtar, E. M. Tuzcu, S. R. Kapadia, L. G. Svensson, R. K. Greenberg, E. E. Roselli, S. Halliburton, V. Kurra, P. Schoenhagen, and S. Sola Aortic root morphology in patients undergoing percutaneous aortic valve replacement: Evidence of aortic root remodeling J. Thorac. Cardiovasc. Surg., April 1, 2009; 137(4): 950 - 956. [Abstract] [Full Text] [PDF]

				A. W. Asgar, M. J. Mullen, N. Delahunty, S. W. Davies, M. Dalby, M. Petrou, A. Kelleher, and N. Moat Transcatheter aortic valve intervention through the axillary artery for the treatment of severe aortic stenosis. J. Thorac. Cardiovasc. Surg., March 1, 2009; 137(3): 773 - 775. [Full Text] [PDF]

				N. Piazza, Y. Onuma, P. de Jaegere, and P. W. Serruys Guidelines for reporting mortality and morbidity after cardiac valve interventions--need for a reappraisal? Ann. Thorac. Surg., February 1, 2009; 87(2): 357 - 358. [Full Text] [PDF]

				N. Khaladj, M. Shrestha, S. Peterss, I. Kutschka, M. Strueber, L. Hoy, A. Haverich, and C. Hagl Isolated surgical aortic valve replacement after previous coronary artery bypass grafting with patent grafts: is this old-fashioned technique obsolete? Eur. J. Cardiothorac. Surg., February 1, 2009; 35(2): 260 - 264. [Abstract] [Full Text] [PDF]

				E. E. Apostolakis, K. Akinosoglou, and D. Dougenis On-pump or off-pump transapical aortic valve implantation provides better clinical outcomes? Eur. J. Cardiothorac. Surg., February 1, 2009; 35(2): 376 - 377. [Full Text] [PDF]

				J. Ye, A. Cheung, S. V. Lichtenstein, L. A. Altwegg, D. R. Wong, R. G. Carere, C. R. Thompson, R. R. Moss, B. Munt, S. Pasupati, et al. Transapical transcatheter aortic valve implantation: 1-year outcome in 26 patients. J. Thorac. Cardiovasc. Surg., January 1, 2009; 137(1): 167 - 173. [Abstract] [Full Text] [PDF]

				D. Oxorn The Intraoperative Quantification of Aortic Stenosis Anesth. Analg., January 1, 2009; 108(1): 10 - 12. [Full Text] [PDF]

				D. Chin Echocardiography for transcatheter aortic valve implantation Eur J Echocardiogr, January 1, 2009; 10(1): i21 - i29. [Abstract] [Full Text] [PDF]

				A. Vahanian, B. Iung, L. Piérard, R. Dion, and J. Pepper CHAPTER 21 Valvular Heart Disease ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]

				H. C. Herrmann Transcatheter Aortic Valve Implantation: Past, Present, and Future Circ Cardiovasc Interv, December 1, 2008; 1(3): 159 - 160. [Full Text] [PDF]

				T. Bottio, V. Tarzia, G. Rizzoli, and G. Gerosa Aortic valve stenosis management: old strategies and future directions Eur. Heart J., November 2, 2008; 29(22): 2821 - 2821. [Full Text] [PDF]

				I. M. SINGH, E. M. TUZCU, M. H. SHISHEHBOR, S. R. KAPADIA, and R. D. CHRISTOFFERSON Percutaneous treatment of aortic valve stenosis Cleveland Clinic Journal of Medicine, November 1, 2008; 75(11): 805 - 812. [Abstract] [Full Text] [PDF]

				V. H. Thourani, R. Myung, P. Kilgo, K. Thompson, J. D. Puskas, O. M. Lattouf, W. A. Cooper, J. D. Vega, E. P. Chen, and R. A. Guyton Long-Term Outcomes After Isolated Aortic Valve Replacement in Octogenarians: A Modern Perspective Ann. Thorac. Surg., November 1, 2008; 86(5): 1458 - 1465. [Abstract] [Full Text] [PDF]

				A. Linke, R. Hollriegel, T. Walther, K. Schierle, C. Wittekind, J. Ender, F. W. Mohr, and G. Schuler Ingrowths of a Percutaneously Implanted Aortic Valve Prosthesis (CoreValve) in a Patient With Severe Aortic Stenosis Circ Cardiovasc Interv, October 1, 2008; 1(2): 155 - 158. [Full Text] [PDF]

				V. C. Babaliaros, D. Liff, E. P. Chen, J. H. Rogers, R. A. Brown, V. H. Thourani, R. A. Guyton, S. Lerakis, A. E. Stillman, P. Raggi, et al. Can Balloon Aortic Valvuloplasty Help Determine Appropriate Transcatheter Aortic Valve Size? J. Am. Coll. Cardiol. Intv., October 1, 2008; 1(5): 580 - 586. [Abstract] [Full Text] [PDF]

				J. Schofer, M. Schluter, H. Treede, O. W. Franzen, T. Tubler, A. Pascotto, R. I. Low, S. F. Bolling, T. Meinertz, and H. Reichenspurner Retrograde Transarterial Implantation of a Nonmetallic Aortic Valve Prosthesis in High-Surgical-Risk Patients With Severe Aortic Stenosis: A First-in-Man Feasibility and Safety Study Circ Cardiovasc Interv, October 1, 2008; 1(2): 126 - 133. [Abstract] [Full Text] [PDF]

				N. Piazza, P. de Jaegere, C. Schultz, A. E. Becker, P. W. Serruys, and R. H. Anderson Anatomy of the Aortic Valvar Complex and Its Implications for Transcatheter Implantation of the Aortic Valve Circ Cardiovasc Interv, August 1, 2008; 1(1): 74 - 81. [Abstract] [Full Text] [PDF]

				T. Bottio The present and the future in aortic stenosis management: are there factors that might preclude surgery? J. Thorac. Cardiovasc. Surg., August 1, 2008; 136(2): 538 - 539. [Full Text] [PDF]

				P. T.L. Chiam and C. E. Ruiz Percutaneous Transcatheter Aortic Valve Implantation: Assessing Results, Judging Outcomes, and Planning Trials: The Interventionalist Perspective J. Am. Coll. Cardiol. Intv., August 1, 2008; 1(4): 341 - 350. [Abstract] [Full Text] [PDF]

				A. Vahanian, O. R. Alfieri, N. Al-Attar, M. J. Antunes, J. Bax, B. Cormier, A. Cribier, P. De Jaegere, G. Fournial, A. P. Kappetein, et al. Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI). Eur. J. Cardiothorac. Surg., July 1, 2008; 34(1): 1 - 8. [Abstract] [Full Text] [PDF]

				L. G. Svensson, T. Dewey, S. Kapadia, E. E. Roselli, A. Stewart, M. Williams, W. N. Anderson, D. Brown, M. Leon, B. Lytle, et al. United States Feasibility Study of Transcatheter Insertion of a Stented Aortic Valve by the Left Ventricular Apex Ann. Thorac. Surg., July 1, 2008; 86(1): 46 - 55. [Abstract] [Full Text] [PDF]

				F. Maisano, I. Michev, P. Denti, O. Alfieri, and A. Colombo Transfemoral transcatheter aortic valve implantation using the balloon expandable SAPIEN transcatheter heart valve device MMCTS, June 26, 2008; 2008(0626): 3087. [Abstract] [Full Text] [PDF]

				S. R. Dixon, C. L. Grines, and W. W. O'Neill The year in interventional cardiology. J. Am. Coll. Cardiol., June 17, 2008; 51(24): 2355 - 2369. [Full Text] [PDF]

				T. Walther, V. Falk, J. Kempfert, M. A. Borger, J. Fassl, M. W.A. Chu, G. Schuler, and F. W. Mohr Transapical minimally invasive aortic valve implantation; the initial 50 patients Eur. J. Cardiothorac. Surg., June 1, 2008; 33(6): 983 - 988. [Abstract] [Full Text] [PDF]

				F. Descoutures, D. Himbert, L. Lepage, B. Iung, D. Detaint, D. Tchetche, E. Brochet, Y. Castier, J.-P. Depoix, P. Nataf, et al. Contemporary surgical or percutaneous management of severe aortic stenosis in the elderly Eur. Heart J., June 1, 2008; 29(11): 1410 - 1417. [Abstract] [Full Text] [PDF]

				A. Vahanian, O. Alfieri, N. Al-Attar, M. Antunes, J. Bax, B. Cormier, A. Cribier, P. De Jaegere, G. Fournial, A. P. Kappetein, et al. Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI) Eur. Heart J., June 1, 2008; 29(11): 1463 - 1470. [Abstract] [Full Text] [PDF]

				A. Sinhal, L. Altwegg, S. Pasupati, K. H. Humphries, M. Allard, P. Martin, A. Cheung, J. Ye, C. Kerr, S. V. Lichtenstein, et al. Atrioventricular Block After Transcatheter Balloon Expandable Aortic Valve Implantation J. Am. Coll. Cardiol. Intv., June 1, 2008; 1(3): 305 - 309. [Abstract] [Full Text] [PDF]

				N. Piazza, Y. Onuma, E. Jesserun, P. P. Kint, A.-M. Maugenest, R. H. Anderson, P. P. T. de Jaegere, and P. W. Serruys Early and Persistent Intraventricular Conduction Abnormalities and Requirements for Pacemaking After Percutaneous Replacement of the Aortic Valve J. Am. Coll. Cardiol. Intv., June 1, 2008; 1(3): 310 - 316. [Abstract] [Full Text] [PDF]

				B. Iung Management of the elderly patient with aortic stenosis Heart, April 1, 2008; 94(4): 519 - 524. [Full Text] [PDF]

				J. G. Webb Percutaneous Aortic Valve Replacement Will Become a Common Treatment for Aortic Valve Disease J. Am. Coll. Cardiol. Intv., April 1, 2008; 1(2): 122 - 126. [Abstract] [Full Text] [PDF]

				B. A. Carabello Aortic Stenosis: A Fatal Disease With But a Single Cure J. Am. Coll. Cardiol. Intv., April 1, 2008; 1(2): 127 - 128. [Full Text] [PDF]

				P. Schoenhagen Back to the future: coronary CT angiography using prospective ECG triggering Eur. Heart J., January 2, 2008; 29(2): 153 - 154. [Full Text] [PDF]

				R. R. Moss, E. Ivens, S. Pasupati, K. Humphries, C. R. Thompson, B. Munt, A. Sinhal, and J. G. Webb Role of echocardiography in percutaneous aortic valve implantation. J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 15 - 24. [Abstract] [Full Text] [PDF]

				W. J. Stewart Imaging the future of transcatheter aortic valve replacement. J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 25 - 28. [Full Text] [PDF]