Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
Circulation. 2007;115:1067-1074
doi: 10.1161/CIRCULATIONAHA.106.633552
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow patientINFORMation
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lanas, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lanas, F.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Heart Attack
Related Collections
Right arrow Acute myocardial infarction
Right arrow Epidemiology
Right arrowRelated Article

(Circulation. 2007;115:1067-1074.)
© 2007 American Heart Association, Inc.


Heart Disease in Latin America

Risk Factors for Acute Myocardial Infarction in Latin America

The INTERHEART Latin American Study

Fernando Lanas, MSc, MD; Alvaro Avezum, MD, PhD; Leonelo E. Bautista, MD, DrPH; Rafael Diaz, MD; Max Luna, MD; Shofiqul Islam, MSc; Salim Yusuf, DPhil, FRCP, for the INTERHEART Investigators in Latin America

From the Facultad de Medicina, Universidad de la Frontera, Temuco, Chile (F.L.); Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil (A.A.); Fundación Cardiovascular del Oriente Colombiano and Department of Population Health Sciences, University of Wisconsin, Madison (L.E.B.); ECLA Coordinating Center and Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.); Unidad de Cirugia Cardiovascular de Guatemala, Guatemala, and Ochsner Clinic Foundation, Covington, La (M.L.); and Population Health Research Institute, Health Sciences and McMaster University, Hamilton, Ontario, Canada (S.I., S.Y.).

Correspondence to Fernando Lanas, Facultad de Medicina, Universidad de La Frontera M, Montt 112 Temuco, Chile. E-mail flanas{at}ufro.cl

Received April 11, 2006; accepted September 5, 2006.

Background— Current knowledge of the impact of cardiovascular risk factors in Latin America is limited.

Methods and Results— As part of the INTERHEART study, 1237 cases of first acute myocardial infarction and 1888 age-, sex-, and center-matched controls were enrolled from Argentina, Brazil, Colombia, Chile, Guatemala, and Mexico. History of smoking, hypertension, diabetes mellitus, diet, physical activity, alcohol consumption, psychosocial factors, anthropometry, and blood pressure were recorded. Nonfasting blood samples were analyzed for apolipoproteins A-1 and B-100. Logistic regression was used to estimate multivariate adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). Persistent psychosocial stress (OR, 2.81; 95% CI, 2.07 to 3.82), history of hypertension (OR, 2.81; 95% CI, 2.39 to 3.31), diabetes mellitus (OR, 2.59; 95% CI, 2.09 to 3.22), current smoking (OR, 2.31; 95% CI, 1.97 to 2.71), increased waist-to-hip ratio (OR for first versus third tertile, 2.49; 95% CI, 1.97 to 3.14), and increased ratio of apolipoprotein B to A-1 (OR for first versus third tertile, 2.31; 95% CI, 1.83 to 2.94) were associated with higher risk of acute myocardial infarction. Daily consumption of fruits or vegetables (OR, 0.63; 95% CI, 0.51 to 0.78) and regular exercise (OR, 0.67; 95% CI, 0.55 to 0.82) reduced the risk of acute myocardial infarction. Abdominal obesity, abnormal lipids, and smoking were associated with high population-attributable risks of 48.5%, 40.8%, and 38.4%, respectively. Collectively, these risk factors accounted for 88% of the population-attributable risk.

Conclusions— Interventions aimed at decreasing behavioral risk factors, lowering blood pressure, and modifying lipids could have a large impact on the risk of acute myocardial infarction among Latin Americans.


Key Words: cardiovascular diseases • epidemiology • Latin America • lipoproteins • myocardial infarction • obesity • risk factors


Find additional patient-related information at:

Risk Factors for Acute Myocardial Infarction in Latin America: The INTERHEART Latin American Study

Related Article:

Issue Highlights
Circulation 2007 115: 1059. [Extract] [Full Text]



This article has been cited by other articles:


Home page
HeartHome page
A Avezum, J Braga, I Santos, H P Guimaraes, J A Marin-Neto, and L S Piegas
Cardiovascular disease in South America: current status and opportunities for prevention
Heart, September 15, 2009; 95(18): 1475 - 1482.
[Abstract] [Full Text] [PDF]


Home page
J. Neurol. Neurosurg. PsychiatryHome page
N L Cabral, A R R Goncalves, A L Longo, C H C Moro, G Costa, C H Amaral, L A M Fonseca, and J Eluf-Neto
Incidence of stroke subtypes, prognosis and prevalence of risk factors in Joinville, Brazil: a 2 year community based study
J. Neurol. Neurosurg. Psychiatry, July 1, 2009; 80(7): 755 - 761.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
C A Polanczyk and J P Ribeiro
Coronary artery disease in Brazil: contemporary management and future perspectives
Heart, June 1, 2009; 95(11): 870 - 876.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
L. B. Moreira, S. C. Fuchs, M. Wiehe, J. L. Neyeloff, R. V. Picon, M. B. Moreira, M. Gus, and F. D. Fuchs
Cardiovascular Risk Attributable to Diabetes in Southern Brazil: A population-based cohort study
Diabetes Care, May 1, 2009; 32(5): 854 - 856.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
M. J. H. J. Dekker, J. W. Koper, M. O. van Aken, H. A. P. Pols, A. Hofman, F. H. de Jong, C. Kirschbaum, J. C. M. Witteman, S. W. J. Lamberts, and H. Tiemeier
Salivary Cortisol Is Related to Atherosclerosis of Carotid Arteries
J. Clin. Endocrinol. Metab., October 1, 2008; 93(10): 3741 - 3747.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
S. C. Smith Jr
Risk Factors for Myocardial Infarction in Latin America: Sobrepeso y Obesidad
Circulation, March 6, 2007; 115(9): 1061 - 1063.
[Full Text] [PDF]