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(Circulation. 2007;115:733-742.)
© 2007 American Heart Association, Inc.

Hypertension

Risk Index for Perioperative Renal Dysfunction/Failure

Critical Dependence on Pulse Pressure Hypertension

Solomon Aronson, MD; Manuel L. Fontes, MD; Yinghui Miao, MD, MPH; Dennis T. Mangano, PhD, MD, for the Investigators of the Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation

From the Duke University Medical Center, Durham, NC (S.A.); Weill Medical College of Cornell University, Ithaca, NY (M.L.F.); and Multicenter Study of Perioperative Ischemia (S.A., M.L.F., D.T.M.) and Ischemia Research and Education Foundation (Y.M., D.T.M.), San Bruno, Calif.

Correspondence to Solomon Aronson, MD, c/o Editorial Office, Ischemia Research Education Foundation, 1111 Bayhill Dr, Ste 480, San Bruno, CA 94066. E-mail diane{at}iref.org

Received March 22, 2006; accepted December 5, 2006.

Background— An acute renal event after coronary bypass graft surgery is associated with high mortality and substantial additive cost.

Methods and Results— This prospective and descriptive study of 4801 patients having coronary bypass graft surgery with cardiopulmonary bypass from November 1996 to June 2000 at 70 centers in 16 countries established associations between predictor variables and postoperative renal composite (renal dysfunction and/or renal failure) from a cohort of 2381 patients and developed a risk index assessed in a validation cohort of 2420 patients. Postoperative renal composite occurred in 231 patients (4.8%). Independent and significant risk factors were age >75 years (odds ratio [OR], 2.04; 95% confidence interval [CI], 1.23 to 3.37; P=0.006), preoperative congestive heart failure (OR, 2.38; CI, 1.55 to 3.64; P<0.001), prior myocardial infarction (OR, 1.75; CI, 1.08 to 2.83; P=0.023), preexisting renal disease (OR, 3.71; CI, 2.41 to 5.70; P<0.001), intraoperative multiple inotrope use (OR, 2.75; CI, 1.75 to 4.31; P<0.001), intraoperative intra-aortic balloon pump insertion (OR, 4.41; CI, 2.21 to 8.80; P<0.001), cardiopulmonary bypass >2 hours (OR, 1.78; CI, 1.15 to 2.74; P=0.01), and preoperative pulse pressure such that for every additional 20–mm Hg increment in pulse pressure >40 mm Hg, there was an OR of 1.49 (CI, 1.17 to 1.89; P=0.001). Patients with pulse pressure hypertension >80 mm Hg were 3 times more likely to die a renal-related death compared with those without (3.7% versus 1.1%).

Conclusions— Beside established risk factors, pulse pressure is independently and significantly associated with increased renal composite.

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