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(Circulation. 2007;115:2907-2908.)
© 2007 American Heart Association, Inc.

Editorial

Cerebroprotection by Hypertension in Ischemic Stroke

The Crumbling of a Hypothesis

Franz H. Messerli, MD

From St Luke’s–Roosevelt Hospital Center, New York, NY.

Correspondence to Dr Franz H. Messerli, Division of Cardiology, St. Luke’s–Roosevelt Hospital Center, Columbia University, College of Physicians and Surgeons, 1000 Tenth Ave, New York, NY 10019. E-mail fmesserli@aol.com

Key Words: Editorials • blood pressure • cerebral infarction • hypertension • stroke

An extract of the first 250 words of the full text is provided, because this article has no abstract.

May not the elevation of systemic blood pressure be a natural response to guarantee a more normal circulation to the heart, brain and kidneys?"¹ These words, taken from a renowned textbook of medicine, clearly illustrate that in the 1940s the teaching doctrine was to consider elevated blood pressure a compensatory mechanism serving to force blood through sclerotic arteries to the ischemic target organs. Hypertension was regarded as "essential" and therefore "should not be tampered with, even were it certain that we could control it."² We have since learned that hypertension is a powerful risk factor for stroke, heart attacks, and renal failure and that lowering blood pressure dramatically reduces the risk of these events. The only clinical situation in which blood pressure elevation often still is considered protective is in the sequence of an acute ischemic stroke. Indeed, authoritative voices such as that of Adams and Victor³ have warned and continue to warn against lowering blood pressure in this setting with statements such as, "We agree with Britton and colleagues that it is prudent to avoid antihypertensive drugs in the first few days unless...the blood pressure is high enough to pose a risk to other organs."³ This statement can be found in the 1989 edition of this venerable neurology textbook and is repeated verbatim in every single subsequent edition until 2005. It thus has taught numerous neurologists that elevated blood pressure in the sequence of an ischemic stroke was a "noli me tangere" and that lowering blood pressure should be . . . [Full Text of this Article]