This Article Free upon publication Full Text Full Text (PDF) All Versions of this Article: 115/22/2822    most recent CIRCULATIONAHA.106.679548v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mega, J. L. Articles by Braunwald, E. Search for Related Content PubMed PubMed Citation Articles by Mega, J. L. Articles by Braunwald, E. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Heart Attack Related Collections Fibrinolysis Other anticoagulants Acute coronary syndromes

(Circulation. 2007;115:2822-2828.)
© 2007 American Heart Association, Inc.

Coronary Heart Disease

Outcomes and Optimal Antithrombotic Therapy in Women Undergoing Fibrinolysis for ST-Elevation Myocardial Infarction

Jessica L. Mega, MD; David A. Morrow, MD, MPH; Erika Östör, MD; Maria Dorobantu, MD, PhD; Jie Qin, MS; Elliott M. Antman, MD; Eugene Braunwald, MD

From the TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital and Department of Medicine, Harvard Medical School, Boston, Mass (J.L.M., D.A.M., J.Q., E.M.A., E.B.); St John’s Hospital, Cardiology Department, Budapest, Hungary (E.O.); and Emergency Hospital of Bucharest, Bucharest, Romania (M.D.).

Correspondence to Jessica L. Mega, MD, TIMI Study Group, Brigham and Women’s Hospital, 350 Longwood Ave, 1st Floor, Boston, MA 02115. E-mail jmega{at}partners.org

Received November 27, 2006; accepted March 21, 2007.

Background— The manifestations, complications, and outcomes of cardiovascular disease differ between women and men. The safety and efficacy of pharmacological reperfusion therapy in women with ST-elevation myocardial infarction are of particular interest.

Methods and Results— We investigated outcomes in the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment–Thrombolysis in Myocardial Infarction (ExTRACT-TIMI) 25 study, which randomized ST-elevation myocardial infarction patients with planned fibrinolysis to enoxaparin or unfractionated heparin. Compared with men (n=15 696), women (n=4783) were older and more likely to have hypertension and diabetes (P<0.001). The unadjusted 30-day mortality rate for women was >2-fold higher than for men (13.2% versus 5.4%; odds ratio, 2.66; 95% CI, 2.40 to 2.96). After adjustment for age, fibrinolytic therapy, revascularization, region, and elements of the TIMI Risk Score, women had a 1.25-fold-higher 30-day risk of death (95% CI, 1.08 to 1.46) but similar risk of intracerebral hemorrhage (adjusted odds ratio, 0.81; 95% CI, 0.52 to 1.26). The 30-day rate of death or nonfatal MI in women was reduced by enoxaparin compared with unfractionated heparin in women (15.4% versus 18.3%; P=0.007). Major bleeding was more frequent in women receiving enoxaparin compared with those receiving unfractionated heparin (2.3% versus 1.4%; P=0.022) but similar among women and men receiving enoxaparin (2.3% versus 2.0%; P=0.39). The rates of death, nonfatal myocardial infarction, or nonfatal major bleeding (net clinical benefit) were lower with enoxaparin (absolute risk reduction, 2.6% in women [P=0.02] and 1.6% in men [P=0.001]).

Conclusions— In ExTRACT-TIMI 25, women presented with a profile of higher baseline risk and increased short-term mortality. In this large, contemporary clinical trial, women had similar relative and greater absolute risk reductions than men when treated with enoxaparin compared with unfractionated heparin as adjunctive therapy with fibrinolysis.

---

 

CLINICAL PERSPECTIVE

This article has been cited by other articles:

				L. Marcoff, Z. Zhang, W. Zhang, E. Ewen, C. Jurkovitz, P. Leguet, P. Kolm, and W. S. Weintraub Cost effectiveness of enoxaparin in acute ST-segment elevation myocardial infarction: the ExTRACT-TIMI 25 (Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thrombolysis In Myocardial Infarction 25) study. J. Am. Coll. Cardiol., September 29, 2009; 54(14): 1271 - 1279. [Abstract] [Full Text] [PDF]

				G. Tatu-Chitoiu, M. Cinteza, M. Dorobantu, M. Udeanu, O. Manfrini, C. Pizzi, M. Vintila, D. D. Ionescu, E. Craiu, D. Burghina, et al. In-hospital case fatality rates for acute myocardial infarction in Romania Can. Med. Assoc. J., June 9, 2009; 180(12): 1207 - 1213. [Abstract] [Full Text] [PDF]

				K P Champney, P D Frederick, H Bueno, S Parashar, J Foody, C N B Merz, J G Canto, J H Lichtman, V Vaccarino, and for the NRMI Investigators The joint contribution of sex, age and type of myocardial infarction on hospital mortality following acute myocardial infarction Heart, June 1, 2009; 95(11): 895 - 899. [Abstract] [Full Text] [PDF]

				R. A. Harrington Women, Acute Ischemic Heart Disease, and Antithrombotic Therapy: Challenges and Opportunities Circulation, June 5, 2007; 115(22): 2796 - 2798. [Full Text] [PDF]