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(Circulation. 2006;114:757-758.)
© 2006 American Heart Association, Inc.

Editorial

A Call for Universal Definitions in Cardiovascular Disease

Joseph S. Alpert, MD; Kristian Thygesen, MD, DSc

From the University of Arizona College of Medicine, Tucson, Ariz (J.S.A.), and Aarhus University Hospital, Aarhus, Denmark (K.T.).

Correspondence to Joseph S. Alpert, MD, Department of Medicine, University of Arizona Health Science Center, 1501 N Campbell Ave, #6334, Tucson, AZ 85724. E-mail jalpert@DeptOfMed.arizona.edu

Key Words: Editorials • myocardial infarction • coronary disease • diagnosis

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Defining concept or object enables humans to communicate effectively with each other concerning that defined entity. Medicine has struggled through its long history to define accurately the various diseases that are a daily component of the human condition. Accurate, clear, and easily interpreted definitions of a disease entity allow physicians to communicate among themselves and ultimately to explain to patients the implications of the specific conditions from which they suffer. The clinical scientist also requires an accurate definition of a specific disease. Often, a checklist is used to assist the investigator in identifying patients with the specific illness that is being studied. If the clinical scientist’s diagnostic criteria are accurate and reproducible, then similar patients with that disease entity can be entered into the clinical trial, the results of which may be generalized for the management of other patients who satisfy the same disease criteria. Furthermore, under favorable circumstances, results from one clinical trial can be compared and even combined with the results of other trials, as long as the same disease definition and criteria were used in the comparative investigations.

Article p 790

Unfortunately, the ideal world of a universally understood and applied definition does not exist in the domain of acute myocardial infarction (MI). Over the many years that clinical research has been performed on patients with acute MI, different definitions using contemporary diagnostic tools have been used, and consequently it is often a challenge to compare the "apples" in 1 study to the "oranges" in another. Similar . . . [Full Text of this Article]

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