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(Circulation. 2006;114:2636-2643.)
© 2006 American Heart Association, Inc.

Interventional Cardiology

A Randomized Study Comparing Same-Day Home Discharge and Abciximab Bolus Only to Overnight Hospitalization and Abciximab Bolus and Infusion After Transradial Coronary Stent Implantation

Olivier F. Bertrand, MD, PhD; Robert De Larochellière, MD; Josep Rodés-Cabau, MD; Guy Proulx, MD; Onil Gleeton, MD; Can Manh Nguyen, MD; Jean-Pierre Déry, MD, MSc; Gérald Barbeau, MD; Bernard Noël, MD; Éric Larose, DVM, MD; Paul Poirier, MD, PhD; Louis Roy, MD, for the Early Discharge After Transradial Stenting of Coronary Arteries (EASY) Study Investigators

From the Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie, affilié à l’Université Laval, Québec, Canada.

Correspondence to Dr Olivier F. Bertrand, MD, PhD, Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie, affilié à l’Université Laval, 2725 Chemin Ste Foy, Québec, Canada G1V 4G5. E-mail Olivier.Bertrand{at}crhl.ulaval.ca

Received May 11, 2006; revision received September 18, 2006; accepted September 22, 2006.

Background— Systematic use of coronary stents and optimized platelet aggregation inhibition has greatly improved the short-term results of percutaneous coronary interventions. Transradial percutaneous coronary interventions have been associated with a low risk of bleeding complications. It is unknown whether moderate- and high-risk patients can be discharged safely the same day after uncomplicated transradial percutaneous coronary interventions.

Methods and Results— We randomized 1005 patients after a bolus of abciximab and uncomplicated transradial percutaneous coronary stent implantation either to same-day home discharge and no infusion of abciximab (group 1, n=504) or to overnight hospitalization and a standard 12-hour infusion of abciximab (group 2, n=501). The primary composite end point of the study was the 30-day incidence of any of the following events: death, myocardial infarction, urgent revascularization, major bleeding, repeat hospitalization, access site complications, and severe thrombocytopenia. The noninferiority of same-day home discharge and bolus of abciximab only compared with overnight hospitalization and abciximab bolus and infusion was evaluated. Two thirds of patients presented with unstable angina and 20% presented with high-risk acute coronary syndrome prior to the procedure. The incidence of the primary end point was 20.4% in group 1 and 18.2% in group 2 (P=0.017 for noninferiority) with a troponin T–based definition of myocardial infarction; the incidence of the primary end point was 11.1% in group 1 and 9.6% in group 2 (P=0.0004 for noninferiority) with a creatinine kinase myocardial band–based definition of myocardial infarction. No death occurred. Rate of major bleeding in both groups was extremely low at 0.8% and 0.2%, respectively. From 504 patients randomized in group 1, 88% were discharged home the same day.

Conclusion— Our data suggest that same-day home discharge after uncomplicated transradial coronary stenting and bolus only of abciximab is not clinically inferior, in a wide spectrum of patients, to the standard overnight hospitalization and a bolus followed by a 12-hour infusion. This novel approach offers a safe strategy for same-day home discharge after uncomplicated coronary intervention.

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