Published online before print November 6, 2006, doi: 10.1161/CIRCULATIONAHA.106.632745
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2006;114:2138-2147.)
© 2006 American Heart Association, Inc.
Heart Failure |
Impaired Chronotropic and Vasodilator Reserves Limit Exercise Capacity in Patients With Heart Failure and a Preserved Ejection Fraction
From the Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore (B.A.B., V.M., S.D.R., K.K., L.C.B., D.A.K.), and Reproductive Biology and Medicine Branch, National Institutes of Child Health and Human Development, NIH, Bethesda (K.P.), Md. Dr Borlaug is currently at the Division of Cardiovascular Disease, Department of Medicine, The Mayo Clinic College of Medicine, Rochester, Minn.
Correspondence to David A. Kass, MD, Abraham and Virginia Weiss Professor of Cardiology, Johns Hopkins Medical Institutions, Ross 835, 720 Rutland Ave, Baltimore, MD 21205. E-mail dkass{at}jhmi.edu
Received April 25, 2006; revision received July 7, 2006; accepted September 1, 2006.
Background— Nearly half of patients with heart failure have a preserved ejection fraction (HFpEF). Symptoms of exercise intolerance and dyspnea are most often attributed to diastolic dysfunction; however, impaired systolic and/or arterial vasodilator reserve under stress could also play an important role.
Methods and Results— Patients with HFpEF (n=17) and control subjects without heart failure (n=19) generally matched for age, gender, hypertension, diabetes mellitus, obesity, and the presence of left ventricular hypertrophy underwent maximal-effort upright cycle ergometry with radionuclide ventriculography to determine rest and exercise cardiovascular function. Resting cardiovascular function was similar between the 2 groups. Both had limited exercise capacity, but this was more profoundly reduced in HFpEF patients (exercise duration 180±71 versus 455±184 seconds; peak oxygen consumption 9.0±3.4 versus 14.4±3.4 mL · kg–1 · min–1; both P<0.001). At matched low-level workload, HFpEF subjects displayed 
40% less of an increase in heart rate and cardiac output and less systemic vasodilation (all P<0.05) despite a similar rise in end-diastolic volume, stroke volume, and contractility. Heart rate recovery after exercise was also significantly delayed in HFpEF patients. Exercise capacity correlated with the change in cardiac output, heart rate, and vascular resistance but not end-diastolic volume or stroke volume. Lung blood volume and plasma norepinephrine levels rose similarly with exercise in both groups.
Conclusions— HFpEF patients have reduced chronotropic, vasodilator, and cardiac output reserve during exercise compared with matched subjects with hypertensive cardiac hypertrophy. These limitations cannot be ascribed to diastolic abnormalities per se and may provide novel therapeutic targets for interventions to improve exercise capacity in this disorder.
CLINICAL PERSPECTIVE
Related Article:
-
Issue Highlights
Circulation 2006 114: 2089.[Full Text]
This article has been cited by other articles:
 |
|
 |
|
  P. D. Chantler, E. G. Lakatta, and S. S. Najjar Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise J Appl Physiol, October 1, 2008; 105(4): 1342 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Chantler, V. Melenovsky, S. P. Schulman, G. Gerstenblith, L. C. Becker, L. Ferrucci, J. L. Fleg, E. G. Lakatta, and S. S. Najjar The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H145 - H153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Handoko and W. J. Paulus Polishing the diastolic dysfunction measurement stick Eur J Echocardiogr, June 11, 2008; (2008) jen181v1. [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Kitzman Diastolic Dysfunction: One Piece of the Heart Failure With Normal Ejection Fraction Puzzle Circulation, April 22, 2008; 117(16): 2044 - 2046. [Full Text] [PDF]
|
|
|
|
|
|
D. Westermann, M. Kasner, P. Steendijk, F. Spillmann, A. Riad, K. Weitmann, W. Hoffmann, W. Poller, M. Pauschinger, H.-P. Schultheiss, et al. Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction Circulation, April 22, 2008; 117(16): 2051 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. W. Nielsen, L. Kober, and C. Torp-Pedersen Heart failure with preserved ejection fraction: dangerous, elusive, and difficult Eur. Heart J., February 1, 2008; 29(3): 285 - 287. [Full Text] [PDF]
|
|
|
|
|
|
L. van Heerebeek, N. Hamdani, M. L. Handoko, I. Falcao-Pires, R. J. Musters, K. Kupreishvili, A. J.J. Ijsselmuiden, C. G. Schalkwijk, J. G.F. Bronzwaer, M. Diamant, et al. Diastolic Stiffness of the Failing Diabetic Heart: Importance of Fibrosis, Advanced Glycation End Products, and Myocyte Resting Tension Circulation, January 1, 2008; 117(1): 43 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Shapiro, C. S.P. Lam, J. B. Patel, S. F. Mohammed, M. Kruger, D. M. Meyer, W. A. Linke, and M. M. Redfield Acute and Chronic Ventricular-Arterial Coupling in Systole and Diastole: Insights From an Elderly Hypertensive Model Hypertension, September 1, 2007; 50(3): 503 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kasner, D. Westermann, P. Steendijk, R. Gaub, U. Wilkenshoff, K. Weitmann, W. Hoffmann, W. Poller, H.-P. Schultheiss, M. Pauschinger, et al. Utility of Doppler Echocardiography and Tissue Doppler Imaging in the Estimation of Diastolic Function in Heart Failure With Normal Ejection Fraction: A Comparative Doppler-Conductance Catheterization Study Circulation, August 7, 2007; 116(6): 637 - 647. [Abstract] [Full Text] [PDF]
|
|