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(Circulation. 2006;114:I-461 – I-466.)
© 2006 American Heart Association, Inc.

Surgery for Coronary Artery Disease

Predictors of Early Neurocognitive Deficits in Low-Risk Patients Undergoing On-Pump Coronary Artery Bypass Surgery

Munir Boodhwani, MD; Fraser D. Rubens, MD, MSc; Denise Wozny, BA; Rosendo Rodriguez, MD, PhD; Abdualla Alsefaou, MD; Paul J. Hendry, MD; Howard J. Nathan, MD

From the Divisions of Cardiac Surgery (M.B., F.D.R., P.J.H.) and Cardiovascular Anesthesia (D.W., R.R., A.A., H.J.N.), University of Ottawa Heart Institute, Ottawa, Canada.

Correspondence to Howard J. Nathan, H341, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada. E-mail hnathan{at}ottawaheart.ca

Background— Postoperative cognitive deficits (POCDs) are a source of morbidity and occur frequently even in low-risk patients undergoing cardiac surgery. Predictors of neurocognitive deficits can identify potentially modifiable risk factors as well as high-risk patients in whom alternate revascularization strategies may be considered.

Methods and Results— 448 patients undergoing coronary surgery (coronary artery bypass graft [CABG]) underwent standardized preoperative and postoperative neurocognitive testing as part of 2 randomized trials evaluating the effects of mild hypothermia during coronary surgery. Prospectively collected data were used to identify univariate predictors of POCDs and multivariable logistic regression models were constructed. Models were bootstrapped 1000 times. POCDs occurred in 59% of patients. Significant univariate predictors included intraoperative normothermia, impaired left ventricular (LV) function, higher educational level, elevated serum creatinine and reduced creatinine clearance, prolonged intubation time, intensive care unit (ICU) stay, and hospital stay. Advanced age, presence of carotid disease, and cardiopulmonary bypass time were not associated with increased POCDs in this cohort. Multivariable modeling identified intraoperative normothermia (odds ratio [95% confidence interval] –1.15 [1.01, 1.31]), poor LV function (1.53 [1.02, 2.30]), and elevated preoperative creatinine (1.01 [1.00 to 1.03] for every 1 mmol/L increase), prolonged (>24 hours) ICU stay (1.88 [1.27 to 2.79]), and higher educational level (1.52 [1.01 to 2.28]) as independent predictors of POCD occurrence.

Conclusions— Mild hypothermia, in the intraoperative and perioperative period, may be a protective strategy for the prevention of POCDs. Patients with elevated pre-operative creatinine and poor LV function carry a higher risk of POCDs and may benefit from revascularization strategies other than conventional on-pump CABG.

Key Words: cardiopulmonary bypass • coronary artery bypass • neurocognitive deficits • risk factors