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(Circulation. 2006;114:I-145 – I-151.)
© 2006 American Heart Association, Inc.

Cell Transplantation and Tissue Engineering

Differential Effect of Intracoronary Infusion of Mobilized Peripheral Blood Stem Cells by Granulocyte Colony–Stimulating Factor on Left Ventricular Function and Remodeling in Patients With Acute Myocardial Infarction Versus Old Myocardial Infarction

The MAGIC Cell-3-DES Randomized, Controlled Trial

Hyun-Jae Kang, MD; Hae-Young Lee, MD; Sang-Hoon Na, MD; Sung-A Chang, MD; Kyung-Woo Park, MD; Hyung-Kwan Kim, MD; Song-Yi Kim, MD; Ho-Joon Chang, MD; Whal Lee, MD; Won Jun Kang, MD; Bon-Kwon Koo, MD; Yong-Jin Kim, MD; Dong Soo Lee, MD; Dae-Won Sohn, MD; Kyou-Sup Han, MD; Byung-Hee Oh, MD; Young-Bae Park, MD; Hyo-Soo Kim, MD

From the Cardiovascular Laboratory, Clinical Research Institute (H-J.K., H-Y.L., S-H.N., S-A.C., K-W.P., H-K.K., S-Y.K., H-J.C., B-K.K., Y-J.K., D-W.S., B-H.O., Y-B.P., H-S.K.), Cardiovascular Center (H-J.K., H-Y.L., S-H.N., S-A.C., K-W.P., H-K.K., S-Y.K., H-J.C., B-K.K., Y-J.K., D-W.S., B-H.O., Y-B.P., H-S.K.), Department of Internal Medicine (H-J.K., H-Y.L., S-H.N., S-A.C., K-W.P., H-K.K., S-Y.K., H-J.C., B-K.K., Y-J.K., D-W.S., B-H.O., Y-B.P., H-S.K.), Department of Radiology (W.L.), Department of Nuclear Medicine (W.J.K., D.S.L.), and Department of Laboratory Medicine (K-S.H.), Seoul National University Hospital, Seoul, Korea

Correspondence to Hyo-Soo Kim, MD or Young-Bae Park, MD, Department of Internal Medicine, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea. E-mail hyosoo{at}snu.ac.kr

Background— The efficacy of intracoronary infusion of granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) has not been compared between patients with acute (AMI) versus old myocardial infarction (OMI). In addition, the potential risk of restenosis associated with G-CSF–based stem cell therapy has not been evaluated in the setting of drug eluting stent (DES) implantation.

Methods and Results— We randomly allocated 96 patients with myocardial infarction who underwent coronary revascularization with DES for the culprit lesion into 4 groups. Eighty-two patients completed 6-month follow-up; AMI cell infusion (n=25), AMI control (n=25), OMI cell infusion (n=16), and OMI control group (n=16). In cell infusion groups, PBSCs were mobilized by G-CSF for 3 days and delivered to infarcted myocardium via intracoronary infusion. The AMI cell infusion group showed a significant additive improvement in left ventricular ejection fraction (LVEF) and remodeling compared with controls (change of LVEF: +5.1±9.1% versus –0.2±8.6%, P<0.05; change of end-systolic volume: –5.4±17.0 mL versus 6.5±21.9 mL, P<0.05). In OMI patients, however, there was no significant change of LVEF and ventricular remodeling in spite of significant improvement of coronary flow reserve after cell infusion. G-CSF–based cell therapy did not aggravate neointimal growth with DES implantation.

Conclusions— Intracoronary infusion of mobilized PBSCs with G-CSF improves LVEF and remodeling in patients with AMI but is less definite in patients with OMI. G-CSF–based stem cell therapy with DES implantation is both feasible and safe, eliminating any potential for restenosis.

Key Words: myocardial infarction • stem cell • G-CSF